Produkte von LKT Laboratories
LKT Laboratories, Inc. in St. Paul, Minnesota, ist ein Forschungs- und Entwicklungsunternehmen, das sich auf die Synthese, Aufreinigung und Isolierung von niedermolekularen Verbindungen konzentriert. Das 1989 gegründete Unternehmen produziert und vermarktet einzigartige (bio-)chemische Substanzen für verschiedenste naturwissenschaftliche Gebiete, insbesondere für die Krebs- und Neurowissenschaft. Bei der Herstellung dieser Wirkstoffe entstehen Substanzen, die auch für die Life-Science-Forschung als Bioreagenzien extrem nützlich sind und von LKT im analytischen Maßstab angeboten werden. Zu den Produkten zählen u.a. Proteinkinase-Inhibitoren sowie Ionenkanal-Modulatoren, die in diversen wissenschaftlichen Anwendungen zum Einsatz kommen.
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Asciminib
Artikelnummer: LKT-A724091.1
Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both...
| Schlagworte: | ABL001, ABL-001, Asciminib free base,... |
| Anwendung: | Allosteric ABL inhibitor, STAMP inhibitor |
| CAS | 1492952-76-7 |
| MW: | 449.84 D |
ab 107,00 €
Ciclesonide
Artikelnummer: LKT-C324091.100
Ciclesonide is an anti-inflammatory corticosteroid. Its active metabolite and several ciclesonide-acetal derivatives have been found to block RNA replication of the SARS-Cov-2 virus. Ciclesonide also inhibits lung cancer stem cells through Hedgehog signaling-mediated SOX2 regulation. Solubility: Insoluble in water....
| Schlagworte: | Alvesco, Omnaris, Zetonna, RPR251526, (R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal... |
| Anwendung: | Corticosteroid |
| CAS | 126544-47-6 |
| MW: | 540.7 D |
ab 139,00 €
Citalopram Chloromethyl Quarternary Ammonium Chloride
Artikelnummer: LKT-C344761.1
| Anwendung: | Citalopram analog |
| MW: | 409.33 D |
ab 146,00 €
Cridanimod
Artikelnummer: LKT-C691325.100
Cridanimod is a STING agonist in mouse cells but not human cells.9-Oxo-10(9H)-acridineacetic acid (CAS 38609-97-1). SMILES: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
| Schlagworte: | 10-carboxymethyl-9-acridanone, CMA, 9-Oxo-10(9H)-acridineacetic acid, 9-Oxoacridine-10-acetic acid |
| Anwendung: | STING agonist |
| CAS | 38609-97-1 |
| MW: | 253.26 D |
ab 100,00 €
1-Deoxynojirimycin
Artikelnummer: LKT-D178589.100
1-Deoxynojirimycin is an alkaloid found in mulberry leaves. It has been found to be important in carbohydrate and lipid metabolism in addition to several other physiological processes. SMILES: C1C(C(C(C(N1)CO)O)O)O
| Schlagworte: | Moranolin, 1,5-Dideoxy-1,5-imino-D-sorbitol, (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol |
| Anwendung: | Anti-diabetic alkaloid |
| CAS | 19130-96-2 |
| MW: | 163.17 D |
ab 94,00 €
DT-2216
Artikelnummer: LKT-D760022.1
DT-2216 is a proteolysis targeting chimera degrader which specifically targets Bcl-xL. SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCC(=O)N4CCN(CC4)CCC(CSC5=CC=CC=C5)NC6=C(C=C(C=C6)S(=O)(=O)NC(=O)C7=CC=C(C=C7)N8CCN(CC8)CC9=C(CCC(C9)(C)C)C1=CC=C(C=C1)Cl)S(=O)(=O)C(F)(F)F)O
| Schlagworte: | DT2216,... |
| Anwendung: | BCL-XL specific degrader |
| CAS | 2365172-42-3 |
| MW: | 1542.36 D |
ab 276,00 €
Everolimus EP Impurity B
Artikelnummer: LKT-E846184.10
Everolimus EP Impurity B is an impurity of Everolimus. Everolimus is an inhibitor of mammalian target of rapamycin 1 (mTOR1) that is used clinically for its immunosuppressive activity in renal transplant recipients and is currently in clinical trials exploring its anticancer chemotherapeutic activity. In...
| Schlagworte: | Everolimus 19-Ene Open-Ring Impurity , seco Everolimus , (19E/Z)-seco-[4-O-(2-Hydroxyethyl)] Rapamycin,... |
| Anwendung: | Everolimus impurity |
| CAS | 1062122-63-7 |
| MW: | 958.2 D |
ab 1.266,00 €
Filipin III
Artikelnummer: LKT-F334453.1
Filipin III is one of the components of Filipin Complex. These compounds are 28-membered ring polyene macrolide antifungal antibiotics. Filipin complex has been found to alter cell membrane structure by interacting with the membrane sterols ergosterol and cholesterol. As such, filipin complex has become a useful...
| Schlagworte: | Filipin, Filimarisin, Filipine,... |
| Anwendung: | Antifungal antibiotic |
| CAS | 480-49-9 |
| MW: | 654.83 D |
ab 256,00 €
GSK3685032
Artikelnummer: LKT-G733404.1
GSK3685032 is an inhibitor of DNA methyltransferase 1. SMILES: CCC1=C(C(=NC(=C1C#N)SC(C2=CC=CC=C2)C(=O)N)N3CCC(CC3)N)C#N
| Schlagworte: | GSK-3685032, 2-[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl-2-phenylacetamide |
| Anwendung: | Reversible DNMT1-selective inhibitor |
| CAS | 2170137-61-6 |
| MW: | 420.54 D |
ab 85,00 €
Gusacitinib
Artikelnummer: LKT-G823720.100
Gusacitinib is a dual inhibitor of SYK/JAK kinases. SMILES: C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
| Schlagworte: | ASN-002, ASN002,... |
| Anwendung: | SYK/JAK inhibitor |
| CAS | 1425381-60-7 |
| MW: | 460.54 D |
ab 115,00 €
H-151
Artikelnummer: LKT-H000051.100
SMILES: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
| Schlagworte: | H151, N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea, 1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea |
| Anwendung: | STING antagonist |
| CAS | 941987-60-6 |
| MW: | 279.34 D |
ab 100,00 €
(S,S)-ICG-001
Artikelnummer: LKT-I088240.1
(S,S)-ICG-001 is an inhibitor of Wnt/beta-catenin signaling. Treatment of nasopharyngeal carcinoma cells with ICG-001 led to reduced capability of the cells to adhere to extracellular matrix and capillary endothelial cells, and reduced tumor cell migration and invasion. In high-fat diet mice, treatment improved...
| Schlagworte: | beta-Catenin Inhibitor,... |
| Anwendung: | Wnt/beta-catenin inhibitor |
| CAS | 847591-62-2 |
| MW: | 548.63 D |
ab 139,00 €