Produkte von LKT Laboratories
LKT Laboratories, Inc. in St. Paul, Minnesota, ist ein Forschungs- und Entwicklungsunternehmen, das sich auf die Synthese, Aufreinigung und Isolierung von niedermolekularen Verbindungen konzentriert. Das 1989 gegründete Unternehmen produziert und vermarktet einzigartige (bio-)chemische Substanzen für verschiedenste naturwissenschaftliche Gebiete, insbesondere für die Krebs- und Neurowissenschaft. Bei der Herstellung dieser Wirkstoffe entstehen Substanzen, die auch für die Life-Science-Forschung als Bioreagenzien extrem nützlich sind und von LKT im analytischen Maßstab angeboten werden. Zu den Produkten zählen u.a. Proteinkinase-Inhibitoren sowie Ionenkanal-Modulatoren, die in diversen wissenschaftlichen Anwendungen zum Einsatz kommen.
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CCCP
Artikelnummer: LKT-C084099.1
CCCP inhibits mitochondrial oxidative phosphorylation. SMILES: C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N
| Schlagworte: | Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone, m-Cl-CCP, Mesoxalonitrile... |
| Anwendung: | Efflux pump inhibitor |
| CAS | 555-60-2 |
| MW: | 204.62 D |
ab 61,00 €
DpC
Artikelnummer: LKT-D604080.100
DpC (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells. SMILES: CN(C1CCCCC1)C(=S)NN=C(C2=CC=CC=N2)C3=CC=CC=N3
| Schlagworte: | N-Cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazinecarbothioamide, DP4cych4mt, CHEMBL2203744, 6068Z4Y7QI,... |
| Anwendung: | Anti-metastatic |
| CAS | 1382469-39-7 |
| MW: | 353.5 D |
ab 207,00 €
R-Equol
Artikelnummer: LKT-E6783.100
R-Equol is the diasteromer of S-Equol. Although S-equol is a naturally occuring isoflavone metabolite in humans, R-equol is not. However, both of these diasteromers are biologically active. SMILES: C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O
| Schlagworte: | (3R)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol |
| Anwendung: | Isoflavone, phytoestrogen found in soy |
| CAS | 221054-79-1 |
| MW: | 242.27 D |
ab 100,00 €
FHD-286
Artikelnummer: LKT-F130280.1
FHD-286 is a BRG1/BRM ATPase inhibitor, which is associated with tumor development and progression. SMILES: CC1CN(CC(O1)C)C2=CC=CC(=N2)C3=CSC(=N3)NC(=O)C(COC)NC(=O)C4=CN(C=C4)S(=O)(=O)C
| Schlagworte: | FHD286,... |
| Anwendung: | BRG1/BRM ATPase inhibitor |
| CAS | 2671128-05-3 |
| MW: | 562.66 D |
ab 276,00 €
Fluorouracil Impurity B
Artikelnummer: LKT-F465818.1
Fluorouracil Impurity B (isobarbituric acid) is an impurity of the pharmaceutical, fluorouracil. SMILES: C1C(=O)C(=O)NC(=O)N1
| Schlagworte: | 5-Hydroxyuracil, Isobarbituric Acid, 2,4,5-Trihydroxypyrimidine, 5-hydroxy-1H-pyrimidine-2,4-dione,... |
| Anwendung: | Fluorouracil impurity |
| CAS | 480-49-9 |
| MW: | 128.09 D |
ab 73,00 €
Grapiprant
Artikelnummer: LKT-G681019.100
Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration of grapiprant, this agent selectively binds to and inhibits the binding of prostaglandin E2 (PGE2) and prevents the activation...
| Schlagworte: | CJ-023423, RQ-00000007, AAT-007,... |
| Anwendung: | EP4 receptor antagonist |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
ab 150,00 €
KB-0742 dihydrochloride
Artikelnummer: LKT-K040009.1
KB-0742 dihydrochloride is a selective CDK9 inhibitor with potent anti-tumor activity in castration-resistant prostate cancer models.
| Schlagworte: | KB0742 dihydrochloride, NSC-834161 dihydrochloride, NSC834161 dihydrochloride,... |
| Anwendung: | CDK9 inhibitor. |
| CAS | 2416874-75-2 |
| MW: | 360.32 D |
ab 146,00 €
LHRH Acetate Salt
Artikelnummer: LKT-L302690.100
Luteinizing hormone-releasing hormone (LHRH or Gonadotropin-releasing hormone [GnRH]) is an endogenous peptide hormone that binds the GnRH receptor, stimulating secretion of reproductive hormones (such as luteinizing hormone [LH ] and follicle-stimulating hormone [FSH]) from the pituitary gland. Analogs of GnRH are...
| Schlagworte: | Gonadorelin, Gonadorelin acetate salt, Luliberin, GnRH, LH-RH, human, pEHWSYGLRPG-NH3 |
| Anwendung: | Endogenous peptide hormone, involved in secretion of reproductive hormones, GnRH agonist. |
| CAS | 33515-09-2 |
| MW: | 1182.31 D |
ab 360,00 €
Monascin
Artikelnummer: LKT-M578522.1
Monascin is a natural product found in Monascus purpureus, Monascus kaoliang, and Monascus pilosus. Monasxin has anti-tumor, anti-inflammatory and anti-oxidative activities. SMILES: CCCCCC(=O)C1C2CC3=C(COC(=C3)C=CC)C(=O)C2(OC1=O)C
| Schlagworte: | Monascoflavin, (3S,3aR,9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]-3,3a,4,8-tetrahydrofuro[3,2-g]isochromene-2,9-dione |
| Anwendung: | Found in red yeast rice |
| CAS | 21516-68-7 |
| MW: | 358.4 D |
ab 749,00 €
MRTX1719
Artikelnummer: LKT-M704793.1
MRTX1719 is an inhibitor of the PRMT5/MTA complex and may be effective against MTAP-deleted cancers. SMILES: CN1C(=C(C=N1)C2=CC3=C(C=C2)C(=O)NN=C3CN)C4=C(C(=CC(=C4F)Cl)OC5CC5)C#N
| Schlagworte: | MRTX-1719,... |
| Anwendung: | PRMT5/MTA complex inhibitor |
| CAS | 2630904-45-7 |
ab 298,00 €
ABT 639
Artikelnummer: LKT-A064766.25
ABT-639 is an orally bioavailable, CaV3.2 T-type calcium channel blocker with potential anti-hyperalgesic activity. Upon oral administration, ABT-639 selectively binds to and blocks the CaV3.2 isoform of the low voltage-gated T-type calcium channels located in peripheral sensory neurons. This prevents the influx of...
| Schlagworte: | ABT639,... |
| Anwendung: | T-type calcium channel blocker |
| CAS | 1235560-28-7 |
| MW: | 455.9 D |
ab 252,00 €
1´-S-1´-Acetoxychavicol Acetate
Artikelnummer: LKT-A0917.10
1'-(S)-1'-Acetoxychavicol acetate (galangal acetate) displays a wide variety of beneficial properties, including antioxidative, anti-obesity, antibacterial, anti-parasitic, chemopreventative, and chemotherapeutic activities. This compound is best known for its ability to inhibit xanthine oxidase, but also activates...
| Schlagworte: | Galangal acetate,(-), Galangal acetate,(S), [4-[(1S)-1-acetyloxyprop-2-enyl]phenyl] acetate |
| Anwendung: | TRPA1 agonist, xanthine oxidase inhibitor. |
| CAS | 52946-22-2 |
| MW: | 234.25 D |
ab 150,00 €