Produkte von GenScript
GenScript Biotech Corporation ist ein weltweit führender Anbieter von Forschungsprodukten zur Unterstützung von Innovationen in den Biowissenschaften. Das umfangreiche Portfolio umfasst kundenspezifische Gene, Peptide, Proteine, Antikörper und Oligonukleotide sowie eine breite Palette an CRISPR-Tools, Klonierungsvektoren, Expressionssystemen und Zellkulturreagenzien. Mit hohen Qualitätsstandards und zuverlässiger Lieferung ermöglicht GenScript Forschern weltweit, ihre Entdeckungen in den Bereichen Molekularbiologie, Immunologie und Arzneimittelentwicklung zu beschleunigen.
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IL-33, Human
Artikelnummer: GSC-Z05499-100
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33,...
| Schlagworte: | IL33, Interleukin-33, Interleukin-1 family member 11, Nuclear factor from high endothelial venules |
| Ursprungsart: | human |
| MW: | 18 kD |
ab 578,00 €
IL-6 R alpha/CD126 hFc Chimera, Human
Artikelnummer: GSC-Z05510-100
Serum levels of interleukin-6 (IL-6) are increased in patients with type 2 diabetes (T2D). IL-6 exerts its pleiotropic effects via the IL-6 alpha-receptor (IL-6R), which exists in membrane-bound and soluble (sIL-6R) forms and activates cells via the beta-receptor glycoprotein 130 (gp130).
| Schlagworte: | IL6R, IL-6R 1, Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha |
| Ursprungsart: | human |
| MW: | 65.3 kD |
ab 524,00 €
IL-6 R alpha/CD126, His & Avi, Human
Artikelnummer: GSC-Z05511-100
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind...
| Schlagworte: | IL6R, IL-6R 1, Membrane glycoprotein 80, Interleukin-6 receptor subunit alpha |
| Ursprungsart: | human |
| MW: | 41.4 kD |
ab 524,00 €
IL-7, Human
Artikelnummer: GSC-Z05512-100
Interleukin-7 (IL7) plays a nonredundant role in T cell survival and homeostasis, which is illustrated in the severe T cell lymphopenia of IL7-deficient mice, or demonstrated in animals or humans that lack expression of either the IL7Ralpha or gamma c chain, the two subunits that constitute the functional IL7 receptor.
| Schlagworte: | IL7, Interleukin-7 |
| Ursprungsart: | human |
| MW: | 17.5 kD |
ab 349,00 €
IL-7 R alpha&TSLPR, His, Human
Artikelnummer: GSC-Z05513-100
IL-7R alpha & TSLPR is an heterodimeric receptor, with TSLP as the ligand, which initiates downstream signaling pathways upon binding to TSLP and subsequently participates in thymus development and immune cell generation. Among them, IL-7R alpha is a component of both the IL-7 and TSLP receptors.
| Schlagworte: | CRLF2, IL-XR, Cytokine receptor-like 2, Cytokine receptor-like factor 2, Thymic stromal lymphopoietin protein receptor |
| Ursprungsart: | human |
| MW: | 31.18/29 kD |
ab 578,00 €
IL-7R alpha/CD127 hFc Chimera, Human
Artikelnummer: GSC-Z05514-100
Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Ralpha and gammac) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
| Schlagworte: | IL7R, CDw127, Interleukin-7 receptor subunit alpha |
| Ursprungsart: | human |
| MW: | 51.6 kD |
ab 376,00 €
Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His &...
Artikelnummer: GSC-Z05532-100
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to...
| Schlagworte: | ITGB6, Integrin beta-6 |
| Ursprungsart: | human |
| MW: | 114/79.1 kD |
ab 632,00 €
Interferon omega-1, His, Human
Artikelnummer: GSC-Z05535-100
Human Interferon omega-1, a type I IFN, also known as IFN-omega1 or IFNW1, it contains a potential N-glycosylation site like human IFN-beta. IFN-omega1 binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. All IFN-omega genes analysed to date are devoid of introns. IFN-omega1 has been...
| Schlagworte: | IFNW1, Interferon omega-1, Interferon alpha-II-1 |
| Ursprungsart: | human |
| MW: | 21.25 kD |
ab 457,00 €
LAMP5 hFc Chimera, Human
Artikelnummer: GSC-Z05561-100
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the...
| Schlagworte: | LAMP5, Brain-associated LAMP-like protein, Lysosome-associated membrane protein 5, Brain and dendritic cell-associated... |
| Ursprungsart: | human |
| MW: | 49.8 kD |
ab 457,00 €
Latent Activin A, His, Human
Artikelnummer: GSC-Z05563-100
Activin-A, a member of the TGF-beta superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals...
| Schlagworte: | INHBA, Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein |
| Ursprungsart: | human |
| MW: | 13.0/32.0 kD |
ab 497,00 €
Latent GDF-8, His, Human
Artikelnummer: GSC-Z05564-100
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-beta family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a...
| Schlagworte: | MSTN, Myostatin, Growth/differentiation factor 8 |
| Ursprungsart: | human |
| MW: | 41.19 kD |
ab 551,00 €
LIF R/CD118 hFc Chimera, Human
Artikelnummer: GSC-Z05581-100
The leukemia inhibitory factor receptor (LIF-R) subunit is a component of cell-surface receptor complexes for the multifunctional cytokines, LIF, cardiotrophin-1, ciliary neurotrophic factor, and human oncostatin M. The structure of the human LIF-R gene is similar to that of the mouse gene. The transmembrane...
| Schlagworte: | LIFR, Leukemia inhibitory factor receptor |
| Ursprungsart: | human |
| MW: | 116.1 kD |
ab 376,00 €