Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-IFNG(emapalumab biosimilar) mAb
Artikelnummer: DIM-BME100141.100
Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and...
| Schlagworte: | Anti-IFN-gamma, Anti-Immune interferon, Anti-IFNG(emapalumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GCGR(volagidemab biosimilar) mAb
Artikelnummer: DIM-BME100142.100
Protein function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting....
| Schlagworte: | Anti-Glucagon receptor, Anti-GL-R, Anti-GCGR(volagidemab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-MASP2(narsoplimab biosimilar) mAb
Artikelnummer: DIM-BME100143.100
Protein function: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. [The UniProt Consortium]
| Schlagworte: | Anti-MASP-2, Anti-MASP2(narsoplimab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-LILRB2 (MK-4830) mAb
Artikelnummer: DIM-BME100145.100
Protein function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes...
| Schlagworte: | Anti-LIR-2, Anti-ILT-4, Anti-MIR-10, Anti-CD85d, Anti-LILRB2 (MK-4830) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-ITGAV(abituzumab biosimilar) mAb
Artikelnummer: DIM-BME100146.100
Protein function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine...
| Schlagworte: | Anti-Integrin alpha-V, Anti-CD51, Anti-ITGAV(abituzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GPC3(Hu9F2) mAb
Artikelnummer: DIM-BME100147.100
Protein function: Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH...
| Schlagworte: | Anti-Glypican-3, Anti-GTR2-2, Anti-MXR7, Anti-Intestinal protein OCI-5, Anti-GPC3(Hu9F2) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-HTRA1(galegenimab biosimilar) mAb
Artikelnummer: DIM-BME100149.100
Protein function: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through...
| Schlagworte: | Anti-L56, Anti-Serine protease 11, Anti-HTRA1(galegenimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GP6(glenzocimab biosimilar) mAb
Artikelnummer: DIM-BME100150.100
Protein function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the...
| Schlagworte: | Anti-Glycoprotein 6, Anti-GPVI, Anti-GP6(glenzocimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-ENPP3(Xencor) mAb
Artikelnummer: DIM-BME100151.100
Protein function: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and...
| Schlagworte: | Anti-CD203c, Anti-NPP3, Anti-PD-Ibeta, Anti-ENPP3(Xencor) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-PDL1 (durvalumab biosimilar) mAb
Artikelnummer: DIM-BME100153.100
Protein function: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443,...
| Schlagworte: | Anti-PD-L1, Anti-CD274, Anti-B7-H1, Anti-PDCD1L1, Anti-PDCD1LG1, Anti-PDL1 (durvalumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CLEC4C (litifilimab biosimilar) mAb
Artikelnummer: DIM-BME100155.100
Protein function: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man...
| Schlagworte: | Anti-BDCA-2, Anti-CD303, Anti-CLEC4C (litifilimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD45 (apamistamab biosimilar) mAb
Artikelnummer: DIM-BME100156.100
Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first...
| Schlagworte: | Anti-B220, Anti-CD45, Anti-CD45R, Anti-GP180, Anti-L-CA, Anti-LCA, Anti-LY5, Anti-T200, Anti-CD45 (apamistamab biosimilar)... |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 120,00 €