Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-ADAM9 (biosimilar) mAb
Artikelnummer: DIM-BME100064.100
Protein function: Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. [The UniProt Consortium]
| Schlagworte: | Anti-CORD9, Anti-MCMP, Anti-MDC9, Anti-Mltng, Anti-ADAM9 (biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GITR(ragifilimab biosimilar) mAb
Artikelnummer: DIM-BME100065.100
Protein function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. [The UniProt Consortium]
| Schlagworte: | Anti-AITR, Anti-GITR, Anti-TNFRSF18, Anti-CD357, Anti-GITR(ragifilimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GUCY2C(indusatumab biosimilar) mAb
Artikelnummer: DIM-BME100067.100
Protein function: Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. [The UniProt Consortium]
| Schlagworte: | Anti-DIAR6, Anti-GC-C, Anti-GUC2C, Anti-MECIL, Anti-MUCIL, Anti-STAR, Anti-GUCY2C(indusatumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-DLL3(Rovalpituzumab biosimilar) mAb
Artikelnummer: DIM-BME100068.100
Protein function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. [The UniProt Consortium]
| Schlagworte: | Anti-SCDO1, Anti-DLL3(Rovalpituzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GPRC5D (Talquetamab biosimilar) mAb
Artikelnummer: DIM-BME100072.100
| Schlagworte: | Anti-GPRC5D, Anti-GPRC5D (Talquetamab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-ROR1 (zilovertamab biosimilar) mAb
Artikelnummer: DIM-BME100073.100
Protein function: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear,...
| Schlagworte: | Anti-ROR1, Anti-NTRKR1, Anti-ROR1 (zilovertamab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-ITGA4 (natalizumab biosimilar) mAb
Artikelnummer: DIM-BME100074.100
Protein function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin...
| Schlagworte: | Anti-CD49D, Anti-IA4, Anti-ITGA4 (natalizumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CLDN18.2 (zolbetuximab biosimilar) mAb
Artikelnummer: DIM-BME100075.100
Protein function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [The UniProt Consortium]
| Schlagworte: | Anti-GC-182, Anti-MAB-362, Anti-MAB362, Anti-laudiximab, Anti-CLDN18.2 (zolbetuximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD47(lemzoparlimab biosimilar) mAb
Artikelnummer: DIM-BME100076.100
Protein function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells...
| Schlagworte: | Anti-CD47, Anti-MER6, Anti-IAP, Anti-CD47(lemzoparlimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-SELP(crizanlizumab biosimilar) mAb
Artikelnummer: DIM-BME100077.100
Protein function: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. [The UniProt Consortium]
| Schlagworte: | Anti-P-Selectin, Anti-CD62P, Anti-SELP, Anti-GMP-140, Anti-SELP(crizanlizumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-B7-H4(alsevalimab biosimilar) mAb
Artikelnummer: DIM-BME100078.100
Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of...
| Schlagworte: | Anti-B7-H4, Anti-B7h.5, Anti-B7H4, Anti-B7S1, Anti-B7X, Anti-PRO1291, Anti-VCTN1, Anti-B7-H4(alsevalimab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TSHR (K1-70) mAb
Artikelnummer: DIM-BME100080.100
Protein function: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate...
| Schlagworte: | Anti-CHNG1, Anti-hTSHR-I, Anti-LGR3, Anti-TSHR (K1-70) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €