Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-CD19 (inebilizumab biosimilar)mAb
Artikelnummer: DIM-BME100051.100
Protein function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead...
| Schlagworte: | Anti-CD19, Anti-4, Anti-VID3, Anti-GC12802, Anti-CD19 (inebilizumab biosimilar)mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-IL-4RA (dupilumab biosimilar)mAb
Artikelnummer: DIM-BME100052.100
Protein function: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In...
| Schlagworte: | Anti-CD124, Anti-IL-4RA, Anti-IL4RA, Anti-IL-4RA (dupilumab biosimilar)mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-OX40( ivuxolimab biosimilar)mAb
Artikelnummer: DIM-BME100053.100
Protein function: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. [The UniProt Consortium]
| Schlagworte: | Anti-TNFRSF4, Anti-OX40, Anti-CD134, Anti-OX40L receptor, Anti-ACT35, Anti-TXGP1L, Anti-OX40( ivuxolimab biosimilar)mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CSF1R(cabiralizumab biosimilar) mAb
Artikelnummer: DIM-BME100055.100
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of...
| Schlagworte: | Anti-CSF1R, Anti-C-FMS, Anti-CD115, Anti-CSFR, Anti-FIM2, Anti-FMS, Anti-M-CSFR, Anti-CSF1R(cabiralizumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TNFa(Adalimumab biosimilar) mAb
Artikelnummer: DIM-BME100056.100
Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia,...
| Schlagworte: | Anti-DIF, Anti-TNF-alpha, Anti-TNFA, Anti-TNFSF2, Anti-cachexin, Anti-cachectin, Anti-TNFalpha, Anti-TNFa(Adalimumab... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-HER3 (patritumab biosimilar)mAb
Artikelnummer: DIM-BME100057.100
Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase...
| Schlagworte: | Anti-HER3, Anti-ERBB3, Anti-HER3 (patritumab biosimilar)mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TNFSF11 (denosumab biosimilar)mAb
Artikelnummer: DIM-BME100058.100
Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the...
| Schlagworte: | Anti-CD254, Anti-hRANKL2, Anti-ODF, Anti-OPGL, Anti-OPTB2, Anti-RANKL, Anti-sOdf, Anti-TNLG6B, Anti-TRANCE, Anti-TNFSF11... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-MUC1(gatipotuzumab biosimilar) mAb
Artikelnummer: DIM-BME100059.100
Protein function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. [The UniProt Consortium]
| Schlagworte: | Anti-ADMCKD, Anti-ADMCKD1, Anti-CA 15-3, Anti-CD227, Anti-EMA, Anti-H23AG, Anti-KL-6, Anti-MAM6, Anti-MCD, Anti-MCKD,... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-VEGFR2 (ramucirumab biosimilar)mAb
Artikelnummer: DIM-BME100060.100
Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of...
| Schlagworte: | Anti-CD309, Anti-FLK1, Anti-VEGFR, Anti-VEGFR2, Anti-VEGFR2 (ramucirumab biosimilar)mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-VEGFA(bevacizumab biosimiar) mAb
Artikelnummer: DIM-BME100061.100
Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin....
| Schlagworte: | Anti-rhuMAb-VEGF, Anti-VEGFA(bevacizumab biosimiar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-LAG3 (relatlimab biosimilar)mAb
Artikelnummer: DIM-BME100062.100
Protein function: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory...
| Schlagworte: | Anti-BMS-986016, Anti-ONO-4482, Anti-LAG3 (relatlimab biosimilar)mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CCR8(10A11) mAb
Artikelnummer: DIM-BME100063.100
Protein function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. [The UniProt Consortium]
| Schlagworte: | Anti-CC-CKR-8, Anti-CCR-8, Anti-CDw198, Anti-CKRL1, Anti-CMKBR8, Anti-CMKBRL2, Anti-CY6, Anti-GPRCY6, Anti-TER1,... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €