Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-TIGIT (etigilimab biosimilar) mAb
Artikelnummer: DIM-BME100024.100
Protein function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. [The UniProt Consortium]
| Schlagworte: | Anti-TIGIT, Anti-SIG9, Anti-STM3, Anti-TIGIT (etigilimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD20 (rituximab biosimilar) mAb
Artikelnummer: DIM-BME100025.100
Protein function: B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). Functions as a store-operated calcium (SOC) channel component...
| Schlagworte: | Anti-B1, Anti-Bp35, Anti-CD20, Anti-CVID5, Anti-LEU-16, Anti-MS4A2, Anti-S7, Anti-CD20 (rituximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TIGIT (tiragolumab biosimilar) mAb
Artikelnummer: DIM-BME100026.100
Protein function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. [The UniProt Consortium]
| Schlagworte: | Anti-TIGIT, Anti-SIG9, Anti-STM3, Anti-TIGIT (tiragolumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TIGIT (vibostolimab biosimilar) mAb
Artikelnummer: DIM-BME100027.100
Protein function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. [The UniProt Consortium]
| Schlagworte: | Anti-TIGIT, Anti-SIG9, Anti-STM3, Anti-TIGIT (vibostolimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-BCMA (belantamab biosimilar) mAb
Artikelnummer: DIM-BME100028.100
Protein function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. [The UniProt Consortium]
| Schlagworte: | Anti-CD269, Anti-TNFRSF17, Anti-BCM, Anti-BCMA, Anti-BCMA (belantamab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD22 (pinatuzumab biosimilar) mAb
Artikelnummer: DIM-BME100029.100
Protein function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids...
| Schlagworte: | Anti-CD22, Anti-SIGLEC2, Anti-BL-CAM, Anti-SIGLEC-2, Anti-Siglec2, Anti-SIGLEC2FLJ22814, Anti-CD22 (pinatuzumab... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TweakR (enavatuzumab biosimilar) mAb
Artikelnummer: DIM-BME100031.100
Protein function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. [The UniProt Consortium]
| Schlagworte: | Anti-TNFRSF12A, Anti-FGF-inducible 14, Anti-FN14, Anti-TweakR, Anti-CD266, Anti-TweakR (enavatuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TNFRSF10B (tigatuzumab biosimilar) mAb
Artikelnummer: DIM-BME100032.100
Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases...
| Schlagworte: | Anti-TNFRSF10B, Anti-TRAILR2, Anti-TRAIL-R2, Anti-CD262, Anti-DR5, Anti-KILLER, Anti-TRICK2, Anti-ZTNFR9, Anti-TRICKB,... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-AXL (enapotamab biosimilar) mAb
Artikelnummer: DIM-BME100033.100
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | Anti-AXL, Anti-UFO, Anti-AXL (enapotamab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-EGFR (Cetuximab biosimilar) mAb
Artikelnummer: DIM-BME100034.100
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,...
| Schlagworte: | Anti-EGFR, Anti-ERBB, Anti-ERBB1, Anti-HER1, Anti-PIG61, Anti-mENA, Anti-EGFR (Cetuximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CEACAM5 (labetuzumab biosimilar) mAb
Artikelnummer: DIM-BME100035.100
Protein function: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6...
| Schlagworte: | Anti-CEACAM-5, Anti-CD66e, Anti-CEA, Anti-Meconium antigen 100, Anti-CEACAM5 (labetuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-ICAM-1 (bersanlimab biosimilar) mAb
Artikelnummer: DIM-BME100036.100
Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. [The UniProt Consortium]
| Schlagworte: | Anti-ICAM1, Anti-BB2, Anti-CD54, Anti-P3.58, Anti-ICAM-1 (bersanlimab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €