Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-B7-H3 (enoblituzumab biosimilar) mAb
Artikelnummer: DIM-BME100010.100
Protein function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant...
| Schlagworte: | Anti-B7-H3, Anti-CD276, Anti-B7 homolog 3, Anti-B7-H3 (enoblituzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-SARS-CoV-2 (CB6 biosimilar) mAb
Artikelnummer: DIM-BME100011.100
Protein function: [Spike protein S1]: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2 (PubMed:32142651, PubMed:33607086, PubMed:32155444). When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell...
| Schlagworte: | Anti-S protein RBD, Anti-Spike glycoprotein Receptor-binding domain, Anti-S glycoprotein RBD, Anti-Spike protein RBD,... |
| Wirt: | Human |
| Spezies-Reaktivität: | SARS-CoV-2 |
ab 120,00 €
Anti-ICOS (vopratelimab biosimilar) mAb
Artikelnummer: DIM-BME100012.100
Protein function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for...
| Schlagworte: | Anti-ICOS, Anti-CD278, Anti-AILIM, Anti-Inducible T-cell costimulator, Anti-ICOS (vopratelimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD33 (gemtuzumab biosimilar) mAb
Artikelnummer: DIM-BME100015.100
Protein function: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked...
| Schlagworte: | Anti-CD33, Anti-SIGLEC3, Anti-gp67, Anti-CD33 (gemtuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-BCMA (biosimilar) mAb
Artikelnummer: DIM-BME100016.100
Protein function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. [The UniProt Consortium]
| Schlagworte: | Anti-CD269, Anti-TNFRSF17, Anti-BCM, Anti-BCMA, Anti-BCMA (biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD30 (brentuximab biosimilar) mAb
Artikelnummer: DIM-BME100017.100
Protein function: Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B (PubMed:8999898). [The UniProt Consortium]
| Schlagworte: | Anti-TNFRSF8, Anti-CD30, Anti-D1S166E, Anti-Ki-1, Anti-CD30 (brentuximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD27 (varlilumab biosimilar) mAb
Artikelnummer: DIM-BME100018.100
Protein function: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. [The UniProt Consortium]
| Schlagworte: | Anti-CD27, Anti-TNFRSF7, Anti-S152, Anti-T14, Anti-Tp55, Anti-CD27 (varlilumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-EPHA3 (ifabotuzumab biosimilar) mAb
Artikelnummer: DIM-BME100019.100
Protein function: Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling...
| Schlagworte: | Anti-TYRO4, Anti-HEK4, Anti-ETK1, Anti-ETK, Anti-EK4, Anti-HEK, Anti-EPHA3 (ifabotuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD40 (iscalimab biosimilar) mAb
Artikelnummer: DIM-BME100020.100
Protein function: Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. [The UniProt Consortium]
| Schlagworte: | Anti-CD40, Anti-Bp50, Anti-CDW40, Anti-MGC9013, Anti-TNFRSF5, Anti-p50, Anti-CD40 (iscalimab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-Mesothelin (amatuximab biosimilar) mAb
Artikelnummer: DIM-BME100021.100
Protein function: Membrane-anchored forms may play a role in cellular adhesion. [The UniProt Consortium]
| Schlagworte: | Anti-MSLN, Anti-Mesothelin, Anti-MPF, Anti-Mesothelin (amatuximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CTLA-4 (ipilimumab biosimilar) mAb
Artikelnummer: DIM-BME100022.100
Protein function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [The UniProt Consortium]
| Schlagworte: | Anti-CTLA4, Anti-CD152, Anti-CTLA-4 (ipilimumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-Trop2 (sacituzumab biosimilar) mAb
Artikelnummer: DIM-BME100023.100
Protein function: May function as a growth factor receptor. [The UniProt Consortium]
| Schlagworte: | Anti-TACSTD2, Anti-GA733-1, Anti-M1S1, Anti-TROP2, Anti-Trop2 (sacituzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €