Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-EGFRVIII antibody(2E12), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101040.10
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,...
| Schlagworte: | Anti-EGFR, Anti-RBB, Anti-RBB1, Anti-ER1, Anti-IG61, Anti-ENA, Anti-EGFRVIII antibody(2E12), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CDH3 antibody(6A10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101041.10
Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. [The UniProt Consortium]
| Schlagworte: | Anti-CDHP, Anti-HJMD, Anti-PCAD, Anti-CDH3 antibody(6A10), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-pTHEMIS antibody(4F2), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101054.10
Protein function: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling...
| Schlagworte: | Anti-THEMIS, Anti-C6orf190, Anti-C6orf207, Anti-pTHEMIS antibody(4F2), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CD3E antibody(1G2), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101085.10
Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z....
| Schlagworte: | Anti-CD3e, Anti-T3E, Anti-CD3E antibody(1G2), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-DLL3 antibody(67E6), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101089.10
Protein function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. [The UniProt Consortium]
| Schlagworte: | Anti-SCDO1, Anti-DLL3 antibody(67E6), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-PVRIG antibody(6G7), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101091.10
Protein function: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. [The UniProt Consortium]
| Schlagworte: | Anti-C7orf15, Anti-CD112R, Anti-PVRIG antibody(6G7), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-PGLYRP1 antibody(1E10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101092.10
Protein function: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity...
| Schlagworte: | Anti-PGRP-S, Anti-PGLYRP1 antibody(1E10), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CD147 antibody(2D2), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101093.10
Protein function: [Isoform 1]: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes...
| Schlagworte: | Anti-Basigin, Anti-BSG, Anti-5F7, Anti-CD147, Anti-EMMPRIN, Anti-M6, Anti-OK, Anti-TCSF, Anti-CD147 antibody(2D2), IgG1... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-B7H7 antibody(2D5), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101094.10
Protein function: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. [The UniProt Consortium]
| Schlagworte: | Anti-HHLA2, Anti-B7H7 antibody(2D5), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-TFRC antibody(7C1), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101095.10
Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH...
| Schlagworte: | Anti-TR, Anti-TfR, Anti-TfR1, Anti-Trfr, Anti-T9, Anti-p90, Anti-CD71, Anti-TFRC antibody(7C1), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-SEZ6 antibody(31A10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101096.10
Protein function: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory...
| Schlagworte: | Anti-BSRPC, Anti-SEZ6 antibody(31A10), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101110.10
Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes...
| Schlagworte: | Anti-Flt-3, Anti-Flk-2, Anti-STK-1, Anti-CD135, Anti-FLK2, Anti-FLT-3, Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €