Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-CXADR antibody(DMC687), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100687.10
Protein function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane...
| Schlagworte: | Anti-CAR, Anti-CAR4:6, Anti-HCAR, Anti-CXADR antibody(DMC687), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-ASGR1 antibody(DMC688), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100688.10
Protein function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is...
| Schlagworte: | Anti-ASGPR, Anti-ASGPR1, Anti-CLEC4H1, Anti-HL-1, Anti-ASGR1 antibody(DMC688), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-ENPP3 antibody(DMC720), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100720.10
Protein function: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and...
| Schlagworte: | Anti-CD203c, Anti-NPP3, Anti-PD-IBETA, Anti-PDNP3, Anti-ENPP3 antibody(DMC720), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100721.10
Protein function: Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of...
| Schlagworte: | Anti-CD221, Anti-IGFIR, Anti-IGFR, Anti-JTK13, Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CD45 antibody(7E1), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100725.10
Protein function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first...
| Schlagworte: | Anti-B220, Anti-CD45, Anti-CD45R, Anti-GP180, Anti-L-CA, Anti-LCA, Anti-LY5, Anti-T200, Anti-CD45 antibody(7E1), IgG1... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-SELPLG antibody(68H10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100741.10
Protein function: A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. [The UniProt Consortium]
| Schlagworte: | Anti-PSGL-1, Anti-PSGL1, Anti-CD162, Anti-Selectin P ligand, Anti-SELPLG antibody(68H10), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CD19 antibody(11B2), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100804.10
Protein function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead...
| Schlagworte: | Anti-CD19, Anti-B4, Anti-CVID3, Anti-MGC12802, Anti-CD19 antibody(11B2), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-ADAM9 antibody(45G10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100832.10
Protein function: Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. [The UniProt Consortium]
| Schlagworte: | Anti-CORD9, Anti-MCMP, Anti-MDC9, Anti-Mltng, Anti-ADAM9 antibody(45G10), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-AXL antibody(1F2), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100868.10
Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface...
| Schlagworte: | Anti-AXL, Anti-UFO, Anti-AXL antibody(1F2), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-PDL1 antibody(23D8), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100875.10
Protein function: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443,...
| Schlagworte: | Anti-PD-L1, Anti-CD274, Anti-B7-H1, Anti-PDCD1L1, Anti-PDCD1LG1, Anti-PDL1 antibody(23D8), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-GPC3 antibody(163D11), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100908.10
Protein function: Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH...
| Schlagworte: | Anti-DGSX, Anti-GTR2-2, Anti-MXR7, Anti-OCI-5, Anti-SDYS, Anti-SGB, Anti-SGBS, Anti-SGBS1, Anti-GPC3 antibody(163D11),... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-GIPR antibody(3G5), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC101001.10
Protein function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. [The UniProt Consortium]
| Schlagworte: | Anti-PGQTL2, Anti-GIPR antibody(3G5), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €