Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-BTLA (tifcemalimab biosimilar) mAb
Artikelnummer: DIM-BME100695.100
Research use only. Protein function: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14...
| Schlagworte: | Icatolimab,JS-004,JS004,JS 004,JS-4,JS4,JS 4,TAB-004,TAB004,TAB 004,TAB-4,TAB4,TAB 4, Anti-CD272, Anti-B- and T-lymphocyte... |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-MAPT (tilavonemab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100696B.100
Research use only. Protein function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein...
| Schlagworte: | ABBV-8E12,ABBV8E12,ABBV 8E12, Anti-MAPTL, Anti-PHF-tau, Anti-Paired helical filament-tau, Anti-Neurofibrillary tangle... |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-TNFRSF10B (tilogotamab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100698B.100
Research use only. Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of...
| Schlagworte: | GEN-1029,GEN1029,GEN 1029, Anti-DR5, Anti-CD262, Anti-TRAIL-R2, Anti-TNFRSF10B, Anti-TRAIL receptor 2, Anti-Death receptor... |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-AXL (tilvestamab biosimilar) mAb
Artikelnummer: DIM-BME100699.100
Research use only. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at...
| Schlagworte: | BGB 149,BGB-149,BGB149, Anti-UFO, Anti-AXL, EC=2.7.10.1, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-AXL (tilvestamab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100699B.100
Research use only. Protein function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at...
| Schlagworte: | BGB 149,BGB-149,BGB149, Anti-UFO, Anti-AXL, EC=2.7.10.1, Anti-AXL oncogene, Anti-Tyrosine-protein kinase receptor UFO |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-PD-1 (tislelizumab biosimilar) mAb
Artikelnummer: DIM-BME100700.100
Research use only. Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell...
| Schlagworte: | BGB-A317,BGB A317,TEVIMBRA,Tilelizumab,VDT-482,VDT 482,VDT482, Anti-CD279, Anti-hPD-1, Anti-Protein PD-1, Anti-Programmed... |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-Trop2 (tizetatug biosimilar) mAb
Artikelnummer: DIM-BME100701.100
Research use only. Protein function: May function as a growth factor receptor. [The UniProt Consortium]
| Schlagworte: | TBC, Anti-GA733-1, Anti-TACSTD2, Anti-Cell surface glycoprotein Trop-2, Anti-Pancreatic carcinoma marker protein GA733-1,... |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-EGFR (tomuzotuximab biosimilar) mAb
Artikelnummer: DIM-BME100702.100
Research use only. Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN,...
| Schlagworte: | GT-MAB 5.2-GEX, Anti-ERBB, EC=2.7.10.1, Anti-Proto-oncogene c-ErbB-1, Anti-Epidermal growth factor receptor, Anti-Receptor... |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-IL33 (torudokimab biosimilar) mAb
Artikelnummer: DIM-BME100704.100
Research use only. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also...
| Schlagworte: | LY-3375880,LY3375880,LY 3375880,ZB-880,ZB880,ZB 880, Anti-C9orf26 |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-IL33 (torudokimab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100704B.100
Research use only. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also...
| Schlagworte: | LY-3375880,LY3375880,LY 3375880,ZB-880,ZB880,ZB 880, Anti-C9orf26 |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-IL33 (tozorakimab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100705B.100
Research use only. Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also...
| Schlagworte: | MEDI-3506,MEDI3506,MEDI 3506, Anti-C9orf26 |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CTLA-4 (tremelimumab biosimilar) mAb, biotinylated
Artikelnummer: DIM-BME100707B.100
Research use only. Protein function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [The UniProt Consortium]
| Schlagworte: | CP-675,CP675,CP 675,CP-675206,CP 675206,CP675206,IMJUDO,Ticilimumab, Anti-CTLA4, Anti-CD152, Anti-CTLA-4, Anti-Cytotoxic... |
| Spezies-Reaktivität: | human |
ab 145,00 €