Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Human GPC3 Protein, hFc Tag
Artikelnummer: DIM-PME100113.10
Recombinant Human GPC3 Protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) GPC3(Asp511-Ser560), Protein function: Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the...
| Schlagworte: | DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 43.3 kD |
ab 176,00 €
Human PMEL Protein, hFc Tag
Artikelnummer: DIM-PME100115.10
Recombinant human PMEL Protein with C-terminal Human Fc tag. PMEL(Lys25-Leu545) hFc(Glu99-Ala330), Protein function: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an...
| Schlagworte: | D12S53E, gp100, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 46.2 kD |
ab 120,00 €
Anti-NKG2D antibody(DMC287), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100287.10
Protein function: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on...
| Schlagworte: | Anti-NKG2D, Anti-CD314, Anti-KLRK1, Anti-NK cell receptor D, Anti-NKG2D antibody(DMC287), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CCR4 antibody(DMC297), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100297.10
Protein function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating...
| Schlagworte: | Anti-CC-CKR-4, Anti-CD194, Anti-ChemR13, Anti-CKR4, Anti-CMKBR4, Anti-HGCN:14099, Anti-K5-5, Anti-CCR4 antibody(DMC297),... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-NKG2A antibody(DMC298), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100298.10
Protein function: Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class...
| Schlagworte: | Anti-CD159A, Anti-NKG2, Anti-NKG2A, Anti-NKG2A antibody(DMC298), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-B7-H5 antibody(DMC299), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100299.10
Protein function: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14- mediated MMP2 activation (PubMed:20666777). [The UniProt Consortium]
| Schlagworte: | Anti-B7-H5, Anti-B7H5, Anti-C10orf54, Anti-DD1alpha, Anti-Dies1, Anti-GI24, Anti-PD-1H, Anti-PP2135, Anti-SISP1,... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CD93 antibody(5B10), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100345.10
Protein function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion....
| Schlagworte: | Anti-C1qR(P), Anti-C1QR1, Anti-C1qRP, Anti-CDw93, Anti-dJ737E23.1, Anti-ECSM3, Anti-MXRA4, Anti-CD93 antibody(5B10), IgG1... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-CFB antibody(DMC366), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100366.10
Protein function: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of...
| Schlagworte: | Anti-AHUS4, Anti-ARMD14, Anti-BF, Anti-BFD, Anti-CFAB, Anti-CFBD, Anti-FB, Anti-FBI12, Anti-GBG, Anti-H2-Bf, Anti-PBF2,... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-ICAM-1 antibody(DMC367), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100367.10
Protein function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. [The UniProt Consortium]
| Schlagworte: | Anti-ICAM1, Anti-BB2, Anti-CD54, Anti-P3.58, Anti-ICAM-1 antibody(DMC367), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-GPR75 antibody(DMC368), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100368.10
Protein function: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a...
| Schlagworte: | Anti-Probable G-protein coupled receptor 75, Anti-GPR75 antibody(DMC368), IgG1 Chimeric mAb |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-HER2 antibody(DMC369), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100369.10
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor....
| Schlagworte: | Anti-ERBB2, Anti-CD340, Anti-HER-2:neu, Anti-HER2, Anti-MLN19, Anti-NEU, Anti-NGL, Anti-TKR1, Anti-HER2 antibody(DMC369),... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €
Anti-ADGRE2 antibody(DMC370), IgG1 Chimeric mAb
Artikelnummer: DIM-DMC100370.10
Protein function: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through...
| Schlagworte: | Anti-Adhesion G protein-coupled receptor E2, Anti-EGF-like module receptor 2, Anti-EGF-like module-containing mucin-like... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 145,00 €