Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Human EGFR Protein, His Tag
Artikelnummer: DIM-PME100099.10
Recombinant human EGFR Protein with C-terminal 6×His tag. EGFR(Leu25-Ser645) 6×His tag, Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725,...
| Schlagworte: | EGFR, ERBB, ERBB1, HER1, PIG61, mENA |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 69.4 kD |
ab 120,00 €
Human TNFSF11 Protein, hFc Tag
Artikelnummer: DIM-PME100100.10
Recombinant human TNFSF11 Protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) TNFSF11(Ile140-Asp317), Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation....
| Schlagworte: | CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TNLG6B, TRANCE |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 48.4 kD |
ab 124,00 €
Human CD46 Protein, His Tag
Artikelnummer: DIM-PME100102.10
Recombinant human CD46 Protein with C-terminal 6×His tag. CD46(Cys35-Tyr328) 6×His tag, Protein function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of...
| Schlagworte: | CD46, AHUS2, MCP, MIC10, TLX, TRA2.10 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 33.5 kD |
ab 105,00 €
Human TGFBR1 Protein, N-hFc Tag
Artikelnummer: DIM-PME100103.10
Recombinant human TGFBR1 Protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) TGFBR1(Leu34-Leu126), Protein function: Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3....
| Schlagworte: | AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-i, TBRI, TGFR-1 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 36.3 kD |
ab 105,00 €
Human VEGFR2 Protein, His Tag
Artikelnummer: DIM-PME100104.10
Recombinant human VEGFR2 Protein with C-terminal 6×His tag. VEGFR2(Ala20-Glu764) 6×His tag, Protein function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic...
| Schlagworte: | CD309, FLK1, VEGFR, VEGFR2 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 84.1 kD |
ab 114,00 €
Human TNFSF12 Protein, hFc Tag
Artikelnummer: DIM-PME100105.10
Recombinant Human TNFSF12 Protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) TNFSF12(Ser94-His249), Protein function: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells....
| Schlagworte: | APO3L, DR3LG, TNLG4A, TWEAK |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 43.3 kD |
ab 105,00 €
Human MUC1 Protein, HisTag
Artikelnummer: DIM-PME100106.10
Recombinant Human MUC1 Protein with C-terminal 6×His tag. MUC1(Leu1036-Val1156) 6×His tag, Protein function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. [The UniProt...
| Schlagworte: | ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 14.4 kD |
ab 114,00 €
Human TIGIT Protein, hFc Tag
Artikelnummer: DIM-PME100107.10
Recombinant human TIGIT Protein with C-terminal human Fc tag. TIGIT(Met22-Pro141) hFc(Glu99-Ala330), Protein function: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of...
| Schlagworte: | TIGIT, VSIG9, VSTM3 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 39.13 kD |
ab 124,00 €
Human CD44 Protein, His Tag
Artikelnummer: DIM-PME100108.10
Recombinant Human CD44 Protein with C-terminal 6×His tag. CD44(Gln21-Pro220) 6×His tag, Protein function: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720,...
| Schlagworte: | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, Epican |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 22.9 kD |
ab 105,00 €
Human IL6R Protein, His Tag
Artikelnummer: DIM-PME100109.10
Recombinant Human IL6R Protein with C-terminal 6×His tag. IL6R(Leu20-Pro365) 6×His tag, Protein function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the...
| Schlagworte: | CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 39.4 kD |
ab 114,00 €
Human VEGFA Protein, His Tag
Artikelnummer: DIM-PME100111.10
Recombinant Human VEGFA Protein with C-terminal 6×His tag. VEGFA(Ala27-Lys147) 6×His tag, Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood...
| Schlagworte: | MVCD1, VEGF, VPF, VEGF206 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 14.8 kD |
ab 124,00 €
Human CCR4 Protein, hFc Tag
Artikelnummer: DIM-PME100112.10
Recombinant Human CCR4 with C-terminal human Fc tag. CCR4(Met1-Glu39)(Ala99-Lys111)(Ser176-Val200)(Val268-Tyr284) hFc(Glu99-Ala330), Protein function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which...
| Schlagworte: | CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 37.1 kD |
ab 120,00 €