Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-CEACAM6(tinurilimab biosimilar) mAb
Artikelnummer: DIM-BME100100.100
Protein function: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner...
| Schlagworte: | Anti-CD66c, Anti-CEAL, Anti-NCA, Anti-CEACAM6(tinurilimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CXCR4(ulocuplumab biosimilar) mAb
Artikelnummer: DIM-BME100101.100
Protein function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in...
| Schlagworte: | Anti-CD184, Anti-D2S201E, Anti-FB22, Anti-HM89, Anti-HSY3RR, Anti-LAP-3, Anti-LAP3, Anti-LCR1, Anti-LESTR, Anti-NPY3R,... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD56(lorvotuzumab biosimilar) mAb
Artikelnummer: DIM-BME100102.100
Protein function: This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. [The UniProt Consortium]
| Schlagworte: | Anti-MSK39, Anti-NCAM, Anti-CD56(lorvotuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-IL21(avizakimab biosimilar) mAb
Artikelnummer: DIM-BME100103.100
Protein function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6,...
| Schlagworte: | Anti-CVID11, Anti-Za11, Anti-IL21(avizakimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-M-CSF(lacnotuzumab biosimilar) mAb
Artikelnummer: DIM-BME100104.100
Protein function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in...
| Schlagworte: | Anti-CSF-1, Anti-MCSF, Anti-M-CSF(lacnotuzumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CCN2(pamrevlumab biosimilar) mAb
Artikelnummer: DIM-BME100105.100
Protein function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells....
| Schlagworte: | Anti-CTGF, Anti-HCS24, Anti-IGFBP8, Anti-NOV2, Anti-CCN2(pamrevlumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-AMHR2(murlentamab biosimilar) mAb
Artikelnummer: DIM-BME100106.100
Protein function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian...
| Schlagworte: | Anti-AMHR, Anti-MISR2, Anti-MISRII, Anti-MRII, Anti-AMHR2(murlentamab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-DKK1(sirexatamab biosimilar) mAb
Artikelnummer: DIM-BME100107.100
Protein function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt...
| Schlagworte: | Anti-DKK-1, Anti-SK, Anti-DKK1(sirexatamab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-B7-H5(onvatilimab biosimilar) mAb
Artikelnummer: DIM-BME100109.100
Protein function: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14- mediated MMP2 activation (PubMed:20666777). [The UniProt Consortium]
| Schlagworte: | Anti-VISTA, Anti-VSIR, Anti-Sisp-1, Anti-C10orf54, Anti-DD1alpha, Anti-Dies1, Anti-GI24, Anti-PD-1H, Anti-PP2135,... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TLR2(tomaralimab biosimilar) mAb
Artikelnummer: DIM-BME100110.100
Protein function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6,...
| Schlagworte: | Anti-CD282, Anti-TIL4, Anti-TLR2(tomaralimab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-LRRC15(samrotamab biosimilar) mAb
Artikelnummer: DIM-BME100111.100
| Schlagworte: | Anti-LIB, Anti-LRC15, Anti-LRRC15(samrotamab biosimilar) mAb |
| Wirt: | Chimeric Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-TSLP(tezepelumab biosimilar) mAb
Artikelnummer: DIM-BME100112.100
Protein function: [Isoform 1]: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. [The UniProt Consortium]
| Schlagworte: | Anti-Thymic stromal lymphopoietin, Anti-TSLP(tezepelumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €