Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Human FGF2 Protein, Flag Tag
Artikelnummer: DIM-PME101612.50
Recombinant human FGF2 Protein with C-terminal 3×Flag tag. Protein function: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the...
| Schlagworte: | bFGF, FGFB, FGF2, FGF-2, HBGF-2, Fibroblast growth factor 2, Basic fibroblast growth factor, Heparin-binding growth factor 2 |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 33.7 kD |
ab 139,00 €
Anti-CCR4(mogamulizumab biosimilar) mAb
Artikelnummer: DIM-BME100086.100
Protein function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating...
| Schlagworte: | Anti-CC-CKR-4, Anti-CD194, Anti-ChemR13, Anti-CKR4, Anti-CMKBR4, Anti-HGCN:14099, Anti-K5-5, Anti-CCR4(mogamulizumab... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CCR2(plozalizumab biosimilar) mAb
Artikelnummer: DIM-BME100087.100
Protein function: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed:8146186, PubMed:8048929, PubMed:23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium...
| Schlagworte: | Anti-CC-CKR-2, Anti-CCR2A, Anti-CCR2B, Anti-CD192, Anti-CKR2, Anti-CKR2A, Anti-CKR2B, Anti-CMKBR2, Anti-MCP-1-R,... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-Nectin-4(enfortumab biosimilar) mAb
Artikelnummer: DIM-BME100088.100
Protein function: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. [The UniProt Consortium]
| Schlagworte: | Anti-EDSS1, Anti-LNIR, Anti-nectin-4, Anti-PRR4, Anti-PVRL4, Anti-Nectin-4(enfortumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-FCRL5(cevostamab biosimilar without anti-CD3...
Artikelnummer: DIM-BME100089.100
Protein function: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. [The UniProt Consortium]
| Schlagworte: | Anti-BXMAS1, Anti-CD307, Anti-CD307e, Anti-FCRH5, Anti-IRTA2, Anti-PRO820, Anti-FCRL5(cevostamab biosimilar without... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GDF15(ponsegromab biosimilar) mAb
Artikelnummer: DIM-BME100090.100
Protein function: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in...
| Schlagworte: | Anti-GDF-15, Anti-MIC-1, Anti-MIC1, Anti-NAG-1, Anti-PDF, Anti-PLAB, Anti-PTGFB, Anti-GDF15(ponsegromab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GFRA3(nadecnemab biosimilar) mAb
Artikelnummer: DIM-BME100091.100
Protein function: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. [The UniProt Consortium]
| Schlagworte: | Anti-GDNFR3, Anti-GFRA3(nadecnemab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD19(FMC63 biosimilar) mAb
Artikelnummer: DIM-BME100094.100
Protein function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead...
| Schlagworte: | Anti-CD19, Anti-4, Anti-VID3, Anti-GC12802, Anti-CD19(FMC63 biosimilar) mAb |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-PCSK9(bococizumab biosimilar) mAb
Artikelnummer: DIM-BME100095.100
Protein function: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and...
| Schlagworte: | Anti-FH3, Anti-FHCL3, Anti-HCHOLA3, Anti-LDLCQ1, Anti-NARC-1, Anti-NARC1, Anti-PC9, Anti-PCSK9(bococizumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-IL1A(bermekimab biosimilar) mAb
Artikelnummer: DIM-BME100097.100
Protein function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to...
| Schlagworte: | Anti-IL-1 alpha, Anti-IL-1A, Anti-IL1, Anti-IL1-ALPHA, Anti-IL1F1, Anti-IL1A(bermekimab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-MIF(imalumab biosimilar) mAb
Artikelnummer: DIM-BME100098.100
Protein function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has...
| Schlagworte: | Anti-GIF, Anti-GLIF, Anti-MMIF, Anti-MIF(imalumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-NOTCH3(tarextumab biosimilar) mAb
Artikelnummer: DIM-BME100099.100
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of...
| Schlagworte: | Anti-CADASIL, Anti-CADASIL1, Anti-CASIL, Anti-IMF2, Anti-LMNS, Anti-NOTCH3(tarextumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €