Produkte von DIMA Biotech
DIMA Biotechnology ist auf präklinische Forschungs- und Entwicklungslösungen für die Biopharmaindustrie spezialisiert. Das umfangreiche Portfolio umfasst mehr als 1.200 Antikörper sowie über 1.500 Proteine und Zytokine. Zu den Proteinen zählt auch eine große Auswahl an vollständigen Transmembranproteinen, für die DIMA mehrere Plattformen entwickelt hat, darunter Nanodisc, virusähnliche Partikel, Membran-Nanopartikel und Exosome. Alle Plattformen basieren auf Säugetier-Expressionssystemen und stellen Membranproteine in voller Länge als lösliche Proteinprodukte mit nativer Konformation und Aktivität her.
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Anti-B7-H4(SGN-B7H4V biosimilar) mAb
Artikelnummer: DIM-BME100197.100
Protein function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T- cells (Treg), in the suppression of...
| Schlagworte: | Anti-VTCN1, Anti-B7-H4(SGN-B7H4V biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-Canine PD-1(INTERVET 4F12) mAb
Artikelnummer: DIM-BME100202.100
| Schlagworte: | Anti-PD1, Anti-PDCD1, Anti-CD279, Anti-SLEB2, Anti-hPD-1, Anti-hPD-l, Anti-hSLE1, Anti-Canine PD-1(INTERVET 4F12) mAb |
| Wirt: | Chimeric Rabbit |
| Spezies-Reaktivität: | dog |
ab 120,00 €
Anti-ANGPTL3(evinacumab biosimilar) mAb
Artikelnummer: DIM-BME100203.100
Protein function: Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a...
| Schlagworte: | Anti-ANL3, Anti-ANG-5, Anti-FHBL2, Anti-ANGPT5, Anti-ANGPTL3(evinacumab biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CCR5(leronlimab biosimilar) mAb
Artikelnummer: DIM-BME100204.100
Protein function: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. [The UniProt...
| Schlagworte: | Anti-CKR5, Anti-CCR-5, Anti-CD195, Anti-CKR-5, Anti-CCCKR5, Anti-CMKBR5, Anti-IDDM22, Anti-CC-CKR-5, Anti-CCR5(leronlimab... |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD14(atibuclimab biosimilar) mAb
Artikelnummer: DIM-BME100205.100
Protein function: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655)....
| Schlagworte: | Anti-CD14, Anti-CD14(atibuclimab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD19(loncastuximab biosimilar) mAb
Artikelnummer: DIM-BME100206.100
Protein function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead...
| Schlagworte: | Anti-CD19, Anti-B4, Anti-CVID3, Anti-MGC12802, Anti-CD19(loncastuximab biosimilar) mAb |
| Wirt: | Chimeric |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-NKG2D(5C5 biosimilar) mAb
Artikelnummer: DIM-BME100207.100
Protein function: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on...
| Schlagworte: | Anti-NKG2D, Anti-CD314, Anti-KLRK1, Anti-NK cell receptor D, Anti-NKG2D(5C5 biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-STEAP1(xaluritamig without CD3 biosimilar) mAb
Artikelnummer: DIM-BME100208.100
Protein function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. [The UniProt Consortium]
| Schlagworte: | Anti-PRSS24, Anti-STEAP, Anti-STEAP1(xaluritamig without CD3 biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GIPR(maridebart biosimilar) mAb
Artikelnummer: DIM-BME100209.100
Protein function: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. [The UniProt Consortium]
| Schlagworte: | Anti-GIP-R, Anti-GIPR(maridebart biosimilar) mAb |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-GM-CSFR(mavrilimumab biosimilar) mAb
Artikelnummer: DIM-BME100213.100
Protein function: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. [The UniProt Consortium]
| Schlagworte: | Anti-GM-CSF-R-alpha, Anti-GMCSFR-alpha, Anti-GMR-alpha, Anti-CDw116, Anti-CD116, Anti-CSF2RA, Anti-CSF2R, Anti-CSF2RY,... |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-CD6(itolizumab biosimilar) mAb
Artikelnummer: DIM-BME100214.100
Protein function: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the...
| Schlagworte: | Anti-TP120, Anti-CD6(itolizumab biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €
Anti-MUC18(AMT 253 biosimilar) mAb
Artikelnummer: DIM-BME100215.100
Protein function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule...
| Schlagworte: | Anti-MCAM, Anti-CD146, Anti-MUC18(AMT 253 biosimilar) mAb |
| Wirt: | Humanized |
| Spezies-Reaktivität: | human |
ab 120,00 €