Produkte von Chimerigen Laboratories
Chimerigen entwickelt und produziert einzigartige, Immunglobulin-basierte, chimäre Fusionsproteine und verwandte Forschungsprodukte mit Hilfe modernster zell- und molekularbiologischen Techniken. Diese Reagenzien werden erfolgreich in der biomedizinischen Grundlagen- und in angewandter Forschung eingesetzt.
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GITRL, Soluble (human) (rec.)
Artikelnummer: CHI-AG-40A-0019-C050
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and...
| Schlagworte: | AITRL, hGITRL, TNFSF18, Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, Tumor necrosis... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~17 kD |
468,00 €
IL-17A (human):Fc (human) (rec.)
Artikelnummer: CHI-AG-40A-0066-C050
Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to...
| Schlagworte: | IL17A, IL-17, CTLA8, IL-17A, CTLA-8, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8 |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~42 kD |
495,00 €
CD276 [B7-H3] (human) (rec.)
Artikelnummer: CHI-HF-200B7H3-C050
CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are...
| Schlagworte: | B7H3, CD276, B7-H3, PSEC0249, 4Ig-B7-H3, B7 homolog 3, CD276 antigen, Costimulatory molecule, B7-H3 |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~35 kD |
391,00 €
B7-H4 (human) (rec.)
Artikelnummer: CHI-HF-200B7H4-C050
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of...
| Schlagworte: | B7h.5, B7-H4, Protein B7S1, B7 homolog 4, T-cell costimulatory molecule B7x, Immune costimulatory protein B7-H4, V-set... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~50 kD |
391,00 €
CD279 [PD-1] (human) (rec.)
Artikelnummer: CHI-HF-200PD1-C050
CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell...
| Schlagworte: | PD1, PDCD1, CD279, hPD-1, Protein PD-1, Programmed cell death protein 1, PD-1, Programmed Cell Death Protein 1 |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~30 kD |
391,00 €
CD274 [B7-H1/PD-L1] (human) (rec.)
Artikelnummer: CHI-HF-200PDL1-C050
Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is...
| Schlagworte: | B7H1, CD274, B7-H1, PD-L1, B7 homolog 1, PDCD1 ligand 1, Programmed death ligand 1, Programmed cell death 1 ligand 1,... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~35 kD |
391,00 €
CD275 [B7-H2] (human) (rec.) (His)
Artikelnummer: CHI-HF-201B7H2-C050
Human B7-H2 is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic...
| Schlagworte: | B7H2, B7-H2, CD275, B7RP-1, ICOSLG, ICOS ligand, B7 homolog 2, B7-related protein 1, B7-like protein Gl50, B7-H2, ICOS... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~40 kD |
391,00 €
B7-H3(4Ig) [B7-H3b] (human) (rec.) (His)
Artikelnummer: CHI-HF-201B7H3B-C050
B7-H3(4Ig) or B7-H3b has two additional Ig-like domains (one V- type and one C- type) and shows a ubiquituous expression pattern. B7-H3(4Ig) is expressed on dendritic cells as well as activated T, B and NK cells. Human (4Ig) binding to an undefined receptor has shown to be inhibitory to NK cell illing and cytokine...
| Schlagworte: | B7H3, CD276, B7-H3, PSEC0249, 4Ig-B7-H3, B7 homolog 3, CD276 antigen, Costimulatory molecule, B7-H3 |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~65 kD |
391,00 €
B7-H4 (human) (rec.) (His)
Artikelnummer: CHI-HF-201B7H4-C050
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of...
| Schlagworte: | B7h.5, B7-H4, Protein B7S1, B7 homolog 4, T-cell costimulatory molecule B7x, Immune costimulatory protein B7-H4, V-set... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~50 kD |
391,00 €
B7-H5 [Gi24] (human) (rec.) (His)
Artikelnummer: CHI-HF-201B7H5-C050
Platelet receptor Gi24 (also known as Dies1 [Differentiation of ESC-1], SISP1 and C10orf54) is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating...
| Schlagworte: | SISP1, PP2135, Sisp-1, C10orf54, Platelet receptor Gi24, Stress-induced secreted protein-1, Platelet Receptor Gi24, Dies1,... |
| Anwendung: | Bioassays |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~32 kD |
391,00 €
CD279 [PD-1] (human) (rec.) (His)
Artikelnummer: CHI-HF-201PD1-C100
CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell...
| Schlagworte: | PD1, CD279, PDCD1, hPD-1, Protein PD-1, Programmed cell death protein 1 |
| Anwendung: | ELISA |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | ~30 kD |
429,00 €
IL-2 (human):Fc (human) (rec.) MultiPack
Artikelnummer: CHI-HF-21002-C050
The extracellular domain of human IL-2 (aa 21-153) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells...
| Schlagworte: | IL2, TCGF, IL-2, Aldesleukin, Interleukin-2, T-cell growth factor |
| Anwendung: | Bioassays |
| Exprimiert in: | Hamster cells |
| Ursprungsart: | human |
264,00 €