Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
Für die Filterung wurden keine Ergebnisse gefunden!
Compound E
Artikelnummer: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
| Schlagworte: | gamma-Secretase Inhibitor XXI,... |
| Anwendung: | gamma-Secretase inhibitor |
| CAS | 209986-17-4 |
| MW: | 490.5 D |
ab 290,00 €
3,3',5'-Triiodo-L-thyronine
Artikelnummer: Cay17598-50
3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...
| Schlagworte: | 3,3',5'-T3, Reverse T3, rT3, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine |
| Anwendung: | TR Delta alpha1 activator |
| CAS | 5817-39-0 |
| MW: | 651 D |
ab 153,00 €
(±)14(15)-EET
Artikelnummer: Cay50651-50
(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary...
| Schlagworte: | (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 197508-62-6 |
| MW: | 320.5 D |
ab 85,00 €
DMOG
Artikelnummer: Cay71210-100
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
| Schlagworte: | Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester |
| Anwendung: | HIF-PH inhibitor |
| CAS | 89464-63-1 |
| MW: | 175.1 D |
ab 40,00 €
Calcitriol
Artikelnummer: Cay71820-1
Calcitriol is a vitamin D3 receptor agonist and active metabolite of vitamin D3 (Cay-11792). It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy vitamin D3 (Cay-9000683) in the liver, followed by further hydroxylation at the 1alpha-position in the kidney. Calcitriol binds...
| Schlagworte: | 1alpha,25-dihydroxy Vitamin D3, 9,10-secocholesta-5Z,7E,10(19)-triene-1alpha,3beta,25-triol |
| Anwendung: | Metabolic studies |
| CAS | 32222-06-3 |
| MW: | 416.6 D |
ab 137,00 €
Arachidonic Acid
Artikelnummer: Cay90010-100
Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
| Schlagworte: | AA, 5Z,8Z,11Z,14Z-eicosatetraenoic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 506-32-1 |
| MW: | 304.5 D |
ab 55,00 €
Phorbol 12-myristate 13-acetate
Artikelnummer: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
| Schlagworte: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
| Anwendung: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.8 D |
ab 60,00 €
(S)-MG132
Artikelnummer: Cay10012628-5
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle...
| Schlagworte: | Z-Leu-Leu-Leu-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Anwendung: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 475.6 D |
ab 40,00 €
Rapamycin
Artikelnummer: Cay13346-1
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) originally isolated from S. hygroscopicus. It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30...
| Schlagworte: | AY 22989, NSC 226080, Wy 090217,... |
| Anwendung: | mTORC1 blocking |
| CAS | 53123-88-9 |
| MW: | 914.2 D |
ab 60,00 €
Prostaglandin F2alpha
Artikelnummer: Cay16010-10
Prostaglandin F2alpha (PGF2alpha) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF2alpha exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine...
| Schlagworte: | Dinoprost, PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid |
| Anwendung: | Bioactive lipid assays |
| CAS | 551-11-1 |
| MW: | 354.5 D |
ab 70,00 €
Angiotensin II (human) (acetate)
Artikelnummer: Cay17150-25
Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two...
| Schlagworte: | 5-L-isoleucine-angiotensin II, acetate |
| Anwendung: | Peptide hormone |
| CAS | 68521-88-0 |
| MW: | 1046.2 D |
ab 40,00 €
Altertoxin I
Artikelnummer: Cay21129-1
Altertoxin I is a natural mycotoxin first isolated from fungi of the genus Alternaria. It is a hydroxyperylenequinone that shows mutagenic activity against S. typhimurium and inhibits human topoisomerase II and bacterial gyrase. Altertoxin I completely inhibits replication of HIV-1 virus at 2.2 µM in a cell-based...
| Schlagworte: | Dihydroalterperylenol, (1S,12aR,12bS)-1,2,11,12,12a,12b-hexahydro-1,4,9,12a-tetrahydroxy-3,10-perylenedione |
| Anwendung: | Mycotoxin |
| CAS | 56258-32-3 |
| MW: | 352.3 D |
ab 485,00 €