Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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BI-87G3
Artikelnummer: Cay42045-1
A JNK1 inhibitor (IC50 = 1.804 µM), selective for JNK1 over p38alpha MAPK, Akt, furin, and lethal factor (IC50s = >100, >100, >100, and >50 µM, respectively), inhibits TNF-alpha-induced JNK1 phosphorylation in HeLa cells (IC50 = ~15 µM). Formulation: A solid. InChI:...
| Schlagworte: | c-Jun N-terminal Kinase Inhibitor XI, JNK Inhibitor XI, 2-[(5-nitro-2-thiazolyl)thio]-benzothiazole |
| Anwendung: | JNK1 inhibitor |
| CAS | 2207-44-5 |
| MW: | 295.4 D |
ab 40,00 €
KEA1-97
Artikelnummer: Cay42049-10
An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in...
| Schlagworte: | 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine |
| Anwendung: | Trx-caspase-3 protein-protein interaction inhibitor |
| CAS | 2138882-71-8 |
| MW: | 335.16 D |
ab 70,00 €
CFT-7455
Artikelnummer: Cay42053-1
A cereblon ligand 1-containing degrader of IKZF1 and IKZF3, reduces levels of IKZF1 and IKZF3 in NCI H929 cells at 0.1 nM, decreases the growth of NCI H929 cells (GI50 = 0.0743 nM), reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model at 30 or 100 µg/kg per day. Formulation: A solid. InChI:...
| Schlagworte: | Cemsidomide, 3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione |
| Anwendung: | Cereblon ligand 1-containing IKZF1 / IKZF3 degrader |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
ab 110,00 €
AZ 13705339
Artikelnummer: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Schlagworte: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Anwendung: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
ab 116,00 €
GAPDH Inhibitor Compound F8
Artikelnummer: Cay42090-1
A covalent inhibitor of GAPDH (IC50 = 39.31 µM), decreases viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. Formulation: A solid. InChI: InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2. InChIKey:...
| Schlagworte: | 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole |
| Anwendung: | GAPDH covalent inhibitor |
| CAS | 252212-58-1 |
| MW: | 366.37 D |
ab 55,00 €
Martinostat
Artikelnummer: Cay42100-10
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)....
| Schlagworte: | N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide |
| Anwendung: | HDAC inhibitor |
| CAS | 1629052-58-9 |
| MW: | 354.5 D |
ab 153,00 €
GSK467
Artikelnummer: Cay42103-1
A JARID1B inhibitor (IC50 = 0.02-0.1 µM), selective for JARID1B over KMD2, -3, -4, and -5 (IC50s = 1-10 µM). Formulation: A solid. InChI: InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23). InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N. SMILES:...
| Schlagworte: | 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]- pyrido[3,4-d]pyrimidin-4(3H)-one |
| Anwendung: | JARID1B (KDM5B) inhibitor |
| CAS | 1628332-52-4 |
| MW: | 319.3 D |
ab 60,00 €
GSK3beta Inhibitor 1
Artikelnummer: Cay42107-10
A GSK3beta inhibitor (IC50 = 4.19 nM), decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-. InChIKey: YKQONSWBHGBDSB-XFXZXTDPSA-N....
| Schlagworte: | Glycogen Synthase Kinase 3beta Inhibitor I, (3Z)-1,3-dihydro-3-(2-pyridinylmethylene)-2H-indol-2-one |
| Anwendung: | GSK3beta inhibitor |
| CAS | 187325-53-7 |
| MW: | 222.2 D |
ab 223,00 €
A-425619
Artikelnummer: Cay42117-10
A TRPV1 antagonist, selective for TRPV1 over a panel of 83 receptors, enzymes, transporters, and ion channels at 10 µM, inhibits capsaicin-, NADA-, anandamide-, or acid-induced increases in intracellular calcium in HEK293 cells expressing human TRPV1 (IC50s = 5, 4, 3, and 2 nM, respectively), increases core body...
| Schlagworte: | N-5-isoquinolinyl-N'-[[4-(trifluoromethyl)phenyl]methyl]-urea |
| Anwendung: | TRPV1 antagonist |
| CAS | 581809-67-8 |
| MW: | 345.3 D |
ab 208,00 €
Ps-Tac
Artikelnummer: Cay42357-1
A quenched fluorescent probe for GSTP1 activity, can be used in live cells, selective for GSTP1 over 18 GST subtypes in MCF-7 cells expressing the recombinant human enzymes, upon glutathionylation by GSTP1, nitrite is released, and the fluorescence of the unquenched glutathionylated fluorescein derivative can be...
| Anwendung: | Quenched fluorescent GSTP1 activity probe |
803,00 €
9,11-methane-epoxy Prostaglandin F1alpha
Artikelnummer: Cay10007850-100
A derivative of PGH1, induces aggregation of isolated rabbit platelet (EC50 = 0.88 µM) and contraction of rabbit aortic strips (EC50 = 0.11 µM), induces contraction of isolated guinea pig tracheas (EC50 = 3.4 µM). Formulation: A solution in methyl acetate. InChI:...
| Schlagworte: | 9,11-epoxymethano PGH1, 9,11-methane-epoxy PGF1alpha,... |
| Anwendung: | Bioactive lipid assays |
| CAS | 72517-81-8 |
| MW: | 352.5 D |
ab 116,00 €
Voacanga africana Ethanol Extract
Artikelnummer: Cay43250-1
A natural extract, contains a crude mixture of bioactive natural products extracted from V. africana. Formulation: A solution in methanol. InChI: . InChIKey: . SMILES:
| Schlagworte: | V. africana Ethanol Extract |
| Anwendung: | Natural extract, crude mixture of bioactive natural products |
76,00 €