Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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PSB-KK1445
Artikelnummer: Cay42093-10
A GPR18 agonist, selective for GPR18 over GPR55 in beta-arrestin recruitment assays using CHO-K1 cells expressing the human receptors (EC50s = 0.0454 and >10 µM, respectively), does not bind to CB1 or CB2 receptors (Kis = >10 µM for both). Formulation: A solid. InChI:...
| Schlagworte: | 7-[(4-fluorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-1H-purine-2,6-dione |
| Anwendung: | GPR18 agonist |
| CAS | 885896-54-8 |
| MW: | 446.5 D |
ab 72,00 €
K114
Artikelnummer: Cay34218-1
A fluorescent probe for the detection of amyloids, pH-dependent ex/em maxima = 370/450 nm, respectively, at pH 8.5, pH-dependent ex/em maxima = 420/520 nm, respectively, at pH 10.5, demonstrates increased fluorescence intensity in the presence of Aß40 fibrils, displays fiber-dependent excitation/emission maxima for...
| Schlagworte: | 4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol |
| Anwendung: | Fluorescent amyloid detection probe |
| CAS | 872201-12-2 |
| MW: | 393.27 D |
ab 40,00 €
I-OMe AG-538
Artikelnummer: Cay35090-1
An IGF-1R and PI5P4Ka inhibitor (IC50s = 3.4 and 1 µM, respectively), selectively cytotoxic to nutrient-deprived PANC-1 cells over nutrient-sufficient PANC-1 cells. Formulation: A solid. InChI: InChI=1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+....
| Schlagworte: | I-OMe Tyrphostin AG-538, 3,4-dihydroxy-aE-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]-beta-oxo-benzenepropanenitrile |
| Anwendung: | IGF-1R / PI5P4Ka inhibitor |
| CAS | 1094048-77-7 |
| MW: | 437.2 D |
ab 45,00 €
Doxycycline (hydrate)
Artikelnummer: Cay35830-1
A broad-spectrum tetracycline antibiotic, inhibits bacterial protein synthesis, selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, at 30 µM, can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or...
| Schlagworte: | (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-... |
| Anwendung: | Broad-spectrum tetracycline antibiotic |
| CAS | 17086-28-1 |
| MW: | 462.45 D |
ab 40,00 €
LNP GalNAc Ligand 1 (trifluoroacetate salt)
Artikelnummer: Cay38952-1
An ASGPR-targeting ligand, has been used in the formation of LNPs for the hepatic delivery of CRISPR base editors in mice. Formulation: A solid. InChI:...
| Schlagworte: | Lipid Nanoparticle GalNAc Ligand 1, Lipid Nanoparticle N-Acetylgalactosamine Ligand 1, LNP N-Acetylgalactosamine Ligand 1,... |
| Anwendung: | ASGPR-targeting ligand |
| CAS | 1159408-65-7 |
| MW: | 1908 D |
ab 70,00 €
9alpha,10alpha-Epoxyhexahydrocannabinol
Artikelnummer: Cay39972-1
An analytical reference standard categorized as a phytocannabinoid metabolite, an active metabolite of Delta9-THC, induces catalepsy and hypothermia and enhances pentobarbital-induced sleep in mice, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Schlagworte: | 1alpha,2alpha-Epoxyhexahydrocannabinol, 9alpha,10alpha-EHHC, 9alpha,10alpha-epoxy HHC,... |
| Anwendung: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 56687-60-6 |
| MW: | 330.46 D |
ab 95,00 €
Palmitoyl-L-carnitine-d9 (chloride)
Artikelnummer: Cay40353-1
An internal standard for the quantification of palmitoyl-L-carnitine by GC- or LC-MS. Formulation: A solid. InChI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1/i2D3,3D3,4D3. InChIKey: XOMRRQXKHMYMOC-UBNSAEOJSA-N. SMILES:...
| Schlagworte: | C16:0 Carnitine-d9, CAR 16:0-d9, Hexadecanoyl-L-carnitine-d9, L-Carnitine hexadecanoyl ester-d9, L-Carnitine palmitoyl... |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification |
| MW: | 445.12 D |
ab 244,00 €
Lirafugratinib
Artikelnummer: Cay40940-1
A covalent FGFR2 inhibitor (IC50 = 0.003 µM), selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively), inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM), reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft...
| Schlagworte: | RLY-4008,... |
| Anwendung: | Covalent FGFR2 inhibitor |
| CAS | 2549174-42-5 |
| MW: | 509.5 D |
ab 55,00 €
LGD 6972 (ammonium salt)
Artikelnummer: Cay40961-1
A GCGR antagonist, reduces glucagon-induced hyperglycemia in wild-type mice, reduces blood glucose levels in mouse models of diabetes. Formulation: A solid. InChI:...
| Schlagworte: | 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]b... |
| Anwendung: | GCGR antagonist |
| MW: | 719.9 D |
ab 74,00 €
CVN293
Artikelnummer: Cay40983-1
A K2P13.1/THIK1 channel inhibitor (IC50 = 49 nM), selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both), inhibits NLRP3 inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM). Formulation: A solid. InChI:...
| Schlagworte: | 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| Anwendung: | K2P13.1/THIK1 channel inhibitor |
| CAS | 2815296-08-1 |
| MW: | 311.27 D |
ab 105,00 €
Anti-Mertansine - Biotinylated
Artikelnummer: Cay41262-100
Immunogen: Mertansine-KLH conjugate Host: Rabbit Species Reactivity: Species-independent Cross Reactivity: (+) Mertansine-conjugated antibodies, (-) Albumin, VcMMAE-conjugated antibodies, unconjugated antibodies Applications: ELISA, WB. Formulation: 100 µg of biotinylated protein A-purified rabbit IgG....
| Schlagworte: | DM1, Drug Maytansinoid 1, Emtansine |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
610,00 €
ECC5004
Artikelnummer: Cay41324-1
A GLP-1R agonist, induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = <20 nM). Formulation: A solid. InChI:...
| Schlagworte: | AZD 5004,... |
| Anwendung: | GLP-1R agonist |
| CAS | 3011682-51-9 |
| MW: | 880.94 D |
299,00 €