Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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WYneN
Artikelnummer: Cay42010-10
A chemoselective probe for protein sulfenylation, selective for sulfenylated proteins over DNTB and 4-DPS, binds to sulfenylated proteins in live cells and can then be conjugated to azide-containing fluorescent probes for detection. Formulation: A solid. InChI:...
| Schlagworte: | Wittig-alkyne N, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-phosphonium, monobromide |
| Anwendung: | Chemoselective protein sulfenylation probe |
| CAS | 3052492-38-0 |
| MW: | 438.3 D |
ab 153,00 €
8alpha,9alpha-epoxy Hexahydrocannabinol
Artikelnummer: Cay42021-1
An analytical reference standard categorized as a phytocannabinoid metabolite, a metabolite of Delta8-THC, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Schlagworte: | 8alpha,9alpha-EEHC, 8alpha,9alpha-epoxy HHC,... |
| Anwendung: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 80513-76-4 |
| MW: | 330.5 D |
ab 95,00 €
PCsBu (hydrochloride)
Artikelnummer: Cay42031-1
An analytical reference standard categorized as an arylcyclohexylamine, intended for research and forensic applications. Formulation: A solid. InChI: InChI=1S/C16H25N.ClH/c1-3-14(2)17-16(12-8-5-9-13-16)15-10-6-4-7-11-15,/h4,6-7,10-11,14,17H,3,5,8-9,12-13H2,1-2H3,1H. InChIKey: SHCLNWOHLQKXRR-UHFFFAOYSA-N. SMILES:...
| Schlagworte: | PCsBuA, N-(1-methylpropyl)-1-phenyl-cyclohexanamine, monohydrochloride |
| Anwendung: | Analytical reference standard, arylcyclohexylamine |
| CAS | 18949-88-7 |
| MW: | 267.84 D |
ab 126,00 €
Metapramine
Artikelnummer: Cay42033-1
An antidepressant, decreases action potential amplitude and maximal signal velocity and increases conduction time in isolated dog Purkinje fibers at 10 µM, reduces ethanol consumption in ethanol-preferring rats at 10 mg/kg, inhibits reperfusion-induced increases in ventricular arrhythmias in a rat model of...
| Schlagworte: | RP 19560, 10,11-dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine |
| Anwendung: | Antidepressant |
| CAS | 21730-16-5 |
| MW: | 238.3 D |
ab 40,00 €
MitoBloCK-10
Artikelnummer: Cay42054-1
A mitochondrial protein import inhibitor, inhibits the import of cytochrome c1 into the mitochondrial intermembrane space in yeast cells at 100 µM, inhibits migration and invasion of, and induces apoptosis and cell cycle arrest at the G1 phase in, primary human bladder cancer cells at 25 µM, induces mitochondrial...
| Schlagworte: | MB-10, 3-fluoro-benzoic acid 2-[(5-nitro-2-thienyl)methylene]hydrazide |
| Anwendung: | Mitochondrial protein import inhibitor |
| CAS | 394694-98-5 |
| MW: | 293.27 D |
ab 40,00 €
MCUF-651
Artikelnummer: Cay42055-10
A GC-A positive allosteric modulator, induces the production of cGMP in the presence (EC50 = 0.45 µM) but not the absence of ANP in HEK293 cells expressing human GC-A, selective for GC-A over GC-B in HEK293 cells expressing the human receptors at 10 µM, binds to the GC-A extracellular domain (Kd = 397 nM) and...
| Schlagworte: | N-(4,6-difluoro-2-benzothiazolyl)-1-[2-(dimethylamino)ethyl]-3-piperidinecarboxamide |
| Anwendung: | GC-A positive allosteric modulator |
| CAS | 2747162-85-0 |
| MW: | 368.45 D |
ab 193,00 €
SB-505124 (hydrochloride)
Artikelnummer: Cay42056-1
An ALK5 and ALK4 inhibitor (IC50s = 47 and 129 nM, respectively), selective for ALK5 and ALK4 over a panel of 27 kinases at 10 µM, inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 µM, inhibits TGF-beta-induced but not TNF-alpha-induced apoptosis in Fao cells at 1...
| Schlagworte: | TGF-beta Receptor Type I Kinase Inhibitor III, TGF-beta RI Kinase Inhibitor III,... |
| Anwendung: | ALK5 / ALK4 inhibitor |
| CAS | 356559-13-2 |
| MW: | 371.9 D |
ab 40,00 €
PVP-037
Artikelnummer: Cay42073-1
A TLR7/8 agonist adjuvant, induces the production of other cytokines and chemokines, including TNF, IFN-gamma, IL-1ß, and IL-6, in primary human PBMCs at =1 µM, increases anti-rHA IgG titers in mice when used as an adjuvant to rHA. Formulation: A solid. InChI:...
| Schlagworte: | a-ethyl-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methylphenyl)-benzeneacetamide |
| Anwendung: | TLR7/8 agonist adjuvant |
| CAS | 862810-50-2 |
| MW: | 370.5 D |
ab 91,00 €
PSB-KK1445
Artikelnummer: Cay42093-10
A GPR18 agonist, selective for GPR18 over GPR55 in beta-arrestin recruitment assays using CHO-K1 cells expressing the human receptors (EC50s = 0.0454 and >10 µM, respectively), does not bind to CB1 or CB2 receptors (Kis = >10 µM for both). Formulation: A solid. InChI:...
| Schlagworte: | 7-[(4-fluorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-1H-purine-2,6-dione |
| Anwendung: | GPR18 agonist |
| CAS | 885896-54-8 |
| MW: | 446.5 D |
ab 72,00 €
K114
Artikelnummer: Cay34218-1
A fluorescent probe for the detection of amyloids, pH-dependent ex/em maxima = 370/450 nm, respectively, at pH 8.5, pH-dependent ex/em maxima = 420/520 nm, respectively, at pH 10.5, demonstrates increased fluorescence intensity in the presence of Aß40 fibrils, displays fiber-dependent excitation/emission maxima for...
| Schlagworte: | 4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-phenol |
| Anwendung: | Fluorescent amyloid detection probe |
| CAS | 872201-12-2 |
| MW: | 393.27 D |
ab 40,00 €
I-OMe AG-538
Artikelnummer: Cay35090-1
An IGF-1R and PI5P4Ka inhibitor (IC50s = 3.4 and 1 µM, respectively), selectively cytotoxic to nutrient-deprived PANC-1 cells over nutrient-sufficient PANC-1 cells. Formulation: A solid. InChI: InChI=1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+....
| Schlagworte: | I-OMe Tyrphostin AG-538, 3,4-dihydroxy-aE-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]-beta-oxo-benzenepropanenitrile |
| Anwendung: | IGF-1R / PI5P4Ka inhibitor |
| CAS | 1094048-77-7 |
| MW: | 437.2 D |
ab 45,00 €
Doxycycline (hydrate)
Artikelnummer: Cay35830-1
A broad-spectrum tetracycline antibiotic, inhibits bacterial protein synthesis, selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, at 30 µM, can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or...
| Schlagworte: | (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-... |
| Anwendung: | Broad-spectrum tetracycline antibiotic |
| CAS | 17086-28-1 |
| MW: | 462.45 D |
ab 40,00 €