Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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AZ 13705339
Artikelnummer: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Schlagworte: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Anwendung: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
ab 116,00 €
GAPDH Inhibitor Compound F8
Artikelnummer: Cay42090-1
A covalent inhibitor of GAPDH (IC50 = 39.31 µM), decreases viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. Formulation: A solid. InChI: InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2. InChIKey:...
| Schlagworte: | 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole |
| Anwendung: | GAPDH covalent inhibitor |
| CAS | 252212-58-1 |
| MW: | 366.37 D |
ab 55,00 €
Martinostat
Artikelnummer: Cay42100-10
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)....
| Schlagworte: | N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide |
| Anwendung: | HDAC inhibitor |
| CAS | 1629052-58-9 |
| MW: | 354.5 D |
ab 153,00 €
GSK467
Artikelnummer: Cay42103-1
A JARID1B inhibitor (IC50 = 0.02-0.1 µM), selective for JARID1B over KMD2, -3, -4, and -5 (IC50s = 1-10 µM). Formulation: A solid. InChI: InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23). InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N. SMILES:...
| Schlagworte: | 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]- pyrido[3,4-d]pyrimidin-4(3H)-one |
| Anwendung: | JARID1B (KDM5B) inhibitor |
| CAS | 1628332-52-4 |
| MW: | 319.3 D |
ab 60,00 €
GSK3beta Inhibitor 1
Artikelnummer: Cay42107-10
A GSK3beta inhibitor (IC50 = 4.19 nM), decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-. InChIKey: YKQONSWBHGBDSB-XFXZXTDPSA-N....
| Schlagworte: | Glycogen Synthase Kinase 3beta Inhibitor I, (3Z)-1,3-dihydro-3-(2-pyridinylmethylene)-2H-indol-2-one |
| Anwendung: | GSK3beta inhibitor |
| CAS | 187325-53-7 |
| MW: | 222.2 D |
ab 223,00 €
A-425619
Artikelnummer: Cay42117-10
A TRPV1 antagonist, selective for TRPV1 over a panel of 83 receptors, enzymes, transporters, and ion channels at 10 µM, inhibits capsaicin-, NADA-, anandamide-, or acid-induced increases in intracellular calcium in HEK293 cells expressing human TRPV1 (IC50s = 5, 4, 3, and 2 nM, respectively), increases core body...
| Schlagworte: | N-5-isoquinolinyl-N'-[[4-(trifluoromethyl)phenyl]methyl]-urea |
| Anwendung: | TRPV1 antagonist |
| CAS | 581809-67-8 |
| MW: | 345.3 D |
ab 208,00 €
Ps-Tac
Artikelnummer: Cay42357-1
A quenched fluorescent probe for GSTP1 activity, can be used in live cells, selective for GSTP1 over 18 GST subtypes in MCF-7 cells expressing the recombinant human enzymes, upon glutathionylation by GSTP1, nitrite is released, and the fluorescence of the unquenched glutathionylated fluorescein derivative can be...
| Anwendung: | Quenched fluorescent GSTP1 activity probe |
803,00 €
9,11-methane-epoxy Prostaglandin F1alpha
Artikelnummer: Cay10007850-100
A derivative of PGH1, induces aggregation of isolated rabbit platelet (EC50 = 0.88 µM) and contraction of rabbit aortic strips (EC50 = 0.11 µM), induces contraction of isolated guinea pig tracheas (EC50 = 3.4 µM). Formulation: A solution in methyl acetate. InChI:...
| Schlagworte: | 9,11-epoxymethano PGH1, 9,11-methane-epoxy PGF1alpha,... |
| Anwendung: | Bioactive lipid assays |
| CAS | 72517-81-8 |
| MW: | 352.5 D |
ab 116,00 €
Voacanga africana Ethanol Extract
Artikelnummer: Cay43250-1
A natural extract, contains a crude mixture of bioactive natural products extracted from V. africana. Formulation: A solution in methanol. InChI: . InChIKey: . SMILES:
| Schlagworte: | V. africana Ethanol Extract |
| Anwendung: | Natural extract, crude mixture of bioactive natural products |
76,00 €
BSA-Stearate Saturated Fatty Acid Complex (0.34 mM)
Artikelnummer: Cay43451-5
A fatty acid substrate, can be used for efficient fatty acid delivery to cells in culture for monitoring fatty acid oxidation or similar processes in various cellular metabolic studies. Formulation: 0.34 mM Stearate:0.17 mM BSA in 150 mM sodium chloride. InChI: . InChIKey: . SMILES:
| Schlagworte: | Bovine Serum Albumin-SA, Bovine Serum Albumin-Stearate, BSA-SA |
| Anwendung: | Fatty acid substrate, efficient fatty acid delivery, cell culture |
| Exprimiert in: | Bovine |
274,00 €
HRP Development Pack
Artikelnummer: Cay502870-1
Contains a high-sensitivity and low-background substrate and stop solution for use with HRP-based ELISAs. Formulation: . InChI: . InChIKey: . SMILES:
| Anwendung: | HRP-based ELISA high-sensitivity / low-background substrates, stop solution |
ab 132,00 €
D-Amino Acid Oxidase Inhibitor
Artikelnummer: Cay23894-100
An inhibitor of DAAO (IC50s = 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively), selective for DAAO over a panel of 150 enzymes, receptors and ion channels (30 µM), inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner (10-200 mg/kg, i.p.), increases levels...
| Schlagworte: | DAAO inhibitor, 4H-thieno[3,2-b]pyrrole-5-carboxylic acid |
| Anwendung: | DAAO inhibitor |
| CAS | 39793-31-2 |
| MW: | 167.2 D |
ab 40,00 €