Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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C8 Ceramide-mPEG(2000)
Artikelnummer: Cay41954-1
A PEGylated form of C8 ceramide, has been used in the generation of lipoplexes and lipid particles for the delivery of plasmid DNA and siRNA in vitro and in vivo, lipid particles encapsulating plasmid DNA and containing C8 MPEG(2000) ceramide have a higher transfection efficiency than those containing C14- or C20...
| Schlagworte: | Capryl Ceramide Methoxy Polyethylene Glycol-2000, N-Capryl-D-erythro-Sphingosine mPEG(2000),... |
| Anwendung: | PEGylated C8 ceramide |
| CAS | 212116-76-2 |
ab 411,00 €
C16 Ceramide-mPEG(2000)
Artikelnummer: Cay41955-1
A PEGylated form of C16 ceramide, has been used in the generation of microspheres, LNPs, and liposomes for the delivery of small molecules, mRNA, and plasmid DNA in vitro and in vivo, liposomes containing C16 ceramide-mPEG(2000) with a stearylated-INF7 and have been used to transfect plasmid DNA into MFLM-4 cells,...
| Schlagworte: | Cer(d18:1/16:0) MPEG(2000), MPEG(2000) Ceramide (d18:1/16:0), N-Hexadecanoyl-D-erythro-Sphingosine mPEG(2000),... |
| Anwendung: | PEGylated C16 ceramide PEGylated form |
| CAS | 212116-78-4 |
ab 74,00 €
DL-Cysteine
Artikelnummer: Cay41968-1
A racemic mixture of D- and L-cysteine, prevents reserpine- and pyloric stenosis-induced gastric ulceration in rats at 5% w/v, improves motility and DNA integrity in frozen and thawed epididymal spermatozoa from cats in cryoprotectants at 5 mM. Formulation: A solid. InChI:...
| Schlagworte: | (±)-Cysteine, (R,S)-Cysteine, NSC 63864 |
| Anwendung: | D-/L-cysteine racemic mixture |
| CAS | 3374-22-9 |
| MW: | 121.16 D |
ab 40,00 €
Fmoc-beta-Alanine
Artikelnummer: Cay41969-10
A building block, has been used in the solid-phase synthesis of glucagon receptor peptide antagonists and bradykinin B1 and B2 receptor pseudopeptide antagonists. Formulation: A solid. InChI: InChI=1S/C18H17NO4/c20-17(21)9-10-19-18(22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,22)(H,20,21)....
| Schlagworte: | Fmoc-beta-Ala-OH, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-beta-alanine |
| Anwendung: | Building block |
| CAS | 35737-10-1 |
| MW: | 311.33 D |
ab 40,00 €
Coumarin 343
Artikelnummer: Cay41970-100
A coumarin laser dye, abs/em = 446/519 nm. Formulation: A solid. InChI: InChI=1S/C16H15NO4/c18-15(19)12-8-10-7-9-3-1-5-17-6-2-4-11(13(9)17)14(10)21-16(12)20/h7-8H,1-6H2,(H,18,19). InChIKey: KCDCNGXPPGQERR-UHFFFAOYSA-N. SMILES: O=C(C1=CC2=C(OC1=O)C(CCCN3CCC4)=C3C4=C2)O
| Schlagworte: | 2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid |
| Anwendung: | Coumarin laser dye |
| CAS | 55804-65-4 |
| MW: | 285.29 D |
ab 55,00 €
ARV-766
Artikelnummer: Cay41985-1
A PROTAC that drives androgen receptor degradation (DC50 = <1 nM), inhibits tumor growth in various LNCaP and VCaP prostate cancer mouse xenograft models, including an enzalutamide-insensitive, non-castrated VCaP model. Formulation: A solid. InChI:...
| Schlagworte: | Luxdegalutamide,... |
| Anwendung: | Androgen receptor degradation driving PROTAC |
| CAS | 2750830-09-0 |
| MW: | 807.95 D |
ab 119,00 €
8beta,9beta-epoxy Hexahydrocannabinol
Artikelnummer: Cay42022-1
An analytical reference standard categorized as a phytocannabinoid metabolite, an active metabolite of Delta8-THC, prolongs pentobarbital-induced sleeping time in mice, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Schlagworte: | 8beta,9beta-EHHC, 8beta,9beta-epoxy HHC,... |
| Anwendung: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 64783-83-1 |
| MW: | 330.46 D |
ab 95,00 €
Paltusotine
Artikelnummer: Cay42041-10
An SST2 agonist, selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively), reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg, reduces plasma levels of IGF-1 in beagle...
| Schlagworte: | CRN00808, 3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-benzonitrile |
| Anwendung: | SST2 agonist |
| CAS | 2172870-89-0 |
| MW: | 456.5 D |
ab 421,00 €
BI-87G3
Artikelnummer: Cay42045-1
A JNK1 inhibitor (IC50 = 1.804 µM), selective for JNK1 over p38alpha MAPK, Akt, furin, and lethal factor (IC50s = >100, >100, >100, and >50 µM, respectively), inhibits TNF-alpha-induced JNK1 phosphorylation in HeLa cells (IC50 = ~15 µM). Formulation: A solid. InChI:...
| Schlagworte: | c-Jun N-terminal Kinase Inhibitor XI, JNK Inhibitor XI, 2-[(5-nitro-2-thiazolyl)thio]-benzothiazole |
| Anwendung: | JNK1 inhibitor |
| CAS | 2207-44-5 |
| MW: | 295.4 D |
ab 40,00 €
KEA1-97
Artikelnummer: Cay42049-10
An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in...
| Schlagworte: | 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine |
| Anwendung: | Trx-caspase-3 protein-protein interaction inhibitor |
| CAS | 2138882-71-8 |
| MW: | 335.16 D |
ab 70,00 €
CFT-7455
Artikelnummer: Cay42053-1
A cereblon ligand 1-containing degrader of IKZF1 and IKZF3, reduces levels of IKZF1 and IKZF3 in NCI H929 cells at 0.1 nM, decreases the growth of NCI H929 cells (GI50 = 0.0743 nM), reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model at 30 or 100 µg/kg per day. Formulation: A solid. InChI:...
| Schlagworte: | Cemsidomide, 3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione |
| Anwendung: | Cereblon ligand 1-containing IKZF1 / IKZF3 degrader |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
ab 110,00 €
AZ 13705339
Artikelnummer: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Schlagworte: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Anwendung: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
ab 116,00 €