Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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9,11-methane-epoxy Prostaglandin F1alpha
Artikelnummer: Cay10007850-100
A derivative of PGH1, induces aggregation of isolated rabbit platelet (EC50 = 0.88 µM) and contraction of rabbit aortic strips (EC50 = 0.11 µM), induces contraction of isolated guinea pig tracheas (EC50 = 3.4 µM). Formulation: A solution in methyl acetate. InChI:...
| Schlagworte: | 9,11-epoxymethano PGH1, 9,11-methane-epoxy PGF1alpha,... |
| Anwendung: | Bioactive lipid assays |
| CAS | 72517-81-8 |
| MW: | 352.5 D |
ab 116,00 €
LNP GalNAc Ligand 1 (trifluoroacetate salt)
Artikelnummer: Cay38952-1
An ASGPR-targeting ligand, has been used in the formation of LNPs for the hepatic delivery of CRISPR base editors in mice. Formulation: A solid. InChI:...
| Schlagworte: | Lipid Nanoparticle GalNAc Ligand 1, Lipid Nanoparticle N-Acetylgalactosamine Ligand 1, LNP N-Acetylgalactosamine Ligand 1,... |
| Anwendung: | ASGPR-targeting ligand |
| CAS | 1159408-65-7 |
| MW: | 1908 D |
ab 70,00 €
9alpha,10alpha-Epoxyhexahydrocannabinol
Artikelnummer: Cay39972-1
An analytical reference standard categorized as a phytocannabinoid metabolite, an active metabolite of Delta9-THC, induces catalepsy and hypothermia and enhances pentobarbital-induced sleep in mice, intended for research and forensic applications. Formulation: A solution in acetonitrile. InChI:...
| Schlagworte: | 1alpha,2alpha-Epoxyhexahydrocannabinol, 9alpha,10alpha-EHHC, 9alpha,10alpha-epoxy HHC,... |
| Anwendung: | Analytical reference standard, phytocannabinoid metabolite |
| CAS | 56687-60-6 |
| MW: | 330.46 D |
ab 95,00 €
Palmitoyl-L-carnitine-d9 (chloride)
Artikelnummer: Cay40353-1
An internal standard for the quantification of palmitoyl-L-carnitine by GC- or LC-MS. Formulation: A solid. InChI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1/i2D3,3D3,4D3. InChIKey: XOMRRQXKHMYMOC-UBNSAEOJSA-N. SMILES:...
| Schlagworte: | C16:0 Carnitine-d9, CAR 16:0-d9, Hexadecanoyl-L-carnitine-d9, L-Carnitine hexadecanoyl ester-d9, L-Carnitine palmitoyl... |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification |
| MW: | 445.12 D |
ab 244,00 €
Lirafugratinib
Artikelnummer: Cay40940-1
A covalent FGFR2 inhibitor (IC50 = 0.003 µM), selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively), inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM), reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft...
| Schlagworte: | RLY-4008,... |
| Anwendung: | Covalent FGFR2 inhibitor |
| CAS | 2549174-42-5 |
| MW: | 509.5 D |
ab 55,00 €
LGD 6972 (ammonium salt)
Artikelnummer: Cay40961-1
A GCGR antagonist, reduces glucagon-induced hyperglycemia in wild-type mice, reduces blood glucose levels in mouse models of diabetes. Formulation: A solid. InChI:...
| Schlagworte: | 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]b... |
| Anwendung: | GCGR antagonist |
| MW: | 719.9 D |
ab 74,00 €
CVN293
Artikelnummer: Cay40983-1
A K2P13.1/THIK1 channel inhibitor (IC50 = 49 nM), selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both), inhibits NLRP3 inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM). Formulation: A solid. InChI:...
| Schlagworte: | 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| Anwendung: | K2P13.1/THIK1 channel inhibitor |
| CAS | 2815296-08-1 |
| MW: | 311.27 D |
ab 105,00 €
Anti-Mertansine - Biotinylated
Artikelnummer: Cay41262-100
Immunogen: Mertansine-KLH conjugate Host: Rabbit Species Reactivity: Species-independent Cross Reactivity: (+) Mertansine-conjugated antibodies, (-) Albumin, VcMMAE-conjugated antibodies, unconjugated antibodies Applications: ELISA, WB. Formulation: 100 µg of biotinylated protein A-purified rabbit IgG....
| Schlagworte: | DM1, Drug Maytansinoid 1, Emtansine |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
610,00 €
ECC5004
Artikelnummer: Cay41324-1
A GLP-1R agonist, induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = <20 nM). Formulation: A solid. InChI:...
| Schlagworte: | AZD 5004,... |
| Anwendung: | GLP-1R agonist |
| CAS | 3011682-51-9 |
| MW: | 880.94 D |
299,00 €
VPS34-IN-19
Artikelnummer: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Schlagworte: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Anwendung: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
ab 147,00 €
MSD-M1PAM
Artikelnummer: Cay41358-1
A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...
| Schlagworte: | PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
| Anwendung: | Muscarinic acetylcholine receptor M1 positive allosteric modulator |
| CAS | 1144504-35-7 |
| MW: | 388.4 D |
ab 80,00 €
O12-D3-I3
Artikelnummer: Cay41385-1
An ionizable cationic lipid (pKa = 6.39), has been used in the generation of LNPs for siRNA delivery in vitro and in vivo, LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells, LNPs containing O12-D3-I3 and an...
| Schlagworte: | didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate |
| Anwendung: | Ionizable cationic lipid, LNP formation |
| MW: | 692.03 D |
ab 60,00 €