Produkte von Cayman Chemical
Cayman Chemical Company ist ein Biotechunternehmen mit Sitz in Ann Arbor, Michigan, das 1980 von Kirk Maxey, M.D. gegründet wurde. Mit seinen biochemischen Produkten unterstützt Cayman Wissenschaftler*innen weltweit bei der Arbeit in den Forschungsfeldern Krebs, NO Signalling, Neurologie, Apoptose, oxidativer Stress, Endokrinologie und vielen weiteren. Cayman Chemical hat sich hierbei besonders auf die Herstellung von Assay-Kits zum Nachweis von Eicosanoiden, freien Radikalen, zyklischen Nukleotiden, Zytokinen, Hormonen und Stickstoffmonoxid spezialisiert. Neben diesen Kits bietet Cayman Chemical ein breites Angebot an Biochemikalien, darunter Eicosanoiden, NO Reagenzien sowie eine Reihe thematisch verwandter Lipide, Fettsäuren, Enzyme und Antikörper.
Mehr Informationen unter: www.caymanchem.com
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DMT7
Artikelnummer: Cay41389-1
An ionizable cationic lipid (pKa = 6.5), has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo, LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast...
| Schlagworte: | 1-(2-(dimethylamino)ethyl)-3-((6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl)thiourea |
| Anwendung: | Ionizable cationic lipid, LNP formation |
| MW: | 658.2 D |
ab 105,00 €
Cell-free Protein Synthesis (E. coli) Kit
Artikelnummer: Cay41534-1
Cell-free protein synthesis (CFPS) is an easy-to-use, rapid, and efficient system that is devoid of membrane-bound barriers but contains the native cellular transcriptional and translational machinery and exogenous resources (e.g., amino acids, nucleotides, and a secondary energy substrate) needed for synthesis of...
| Schlagworte: | CFPS |
| Anwendung: | Cell-free protein synthesis |
345,00 €
E17241
Artikelnummer: Cay41675-1
An inducer of ABCA1 expression, induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM), an agonist of PPARs, induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARgamma, PPARalpha, or PPARdelta (EC50s = 290, 3,900, and 879 nM, respectively),...
| Schlagworte: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| Anwendung: | ABCA1 expression inducer |
| CAS | 1060968-92-4 |
| MW: | 318.4 D |
ab 70,00 €
Werner Syndrome RecQ Helicase-IN-2
Artikelnummer: Cay41678-1
An inhibitor of WRN (IC50 = 100 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 100 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 120 mg/kg per day. Formulation: A solid. InChI:...
| Schlagworte: | Werner Syndrome RecQ Helicase Inhibitor 2, WS RecQ Helicase Inhibitor 2, WS RecQ Helicase-IN-2,... |
| Anwendung: | WRN inhibitor |
| CAS | 2869954-51-6 |
| MW: | 681.7 D |
ab 153,00 €
Lipid A
Artikelnummer: Cay41708-1
An ionizable cationic lipid (pKa = 4.67). Formulation: A solution in ethanol. InChI: InChI=1S/C48H95NO5/c1-6-11-15-19-21-29-37-44(35-27-17-13-8-3)47(51)53-41-33-25-23-31-39-49(46(10-5)43-50)40-32-24-26-34-42-54-48(52)45(36-28-18-14-9-4)38-30-22-20-16-12-7-2/h44-46,50H,6-43H2,1-5H3. InChIKey:...
| Schlagworte: | 2-hexyl-decanoic acid, 1,1'-[[[1-(hydroxymethyl)propyl]imino]di-6,1-hexanediyl] ester |
| Anwendung: | Ionizable cationic lipid |
| CAS | 2036273-20-6 |
| MW: | 766.27 D |
ab 120,00 €
DC-U4106
Artikelnummer: Cay41723-1
A USP8 inhibitor (IC50 = 1.2 µM), selective for USP8 over USP2 and USP7 (IC50s = 58.4 and >100 µM, respectively), induces apoptosis in, and inhibits colony formation by, MCF-7 cells from 1-5 µM, reduces tumor volume in an MCF-7 mouse xenograft model at 20 mg/kg. Formulation: A solid. InChI:...
| Schlagworte: | 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-4H-1-benzopyran-4-one |
| Anwendung: | USP8 inhibitor |
| CAS | 2410534-62-0 |
| MW: | 525.6 D |
ab 223,00 €
Spongosine
Artikelnummer: Cay41832-1
A nucleoside with diverse biological activities, antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors), inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM, decreases...
| Schlagworte: | 2-Methoxyadenosine, NSC 36899, 2-methoxy-adenosine |
| Anwendung: | Bioactive nucleoside |
| CAS | 24723-77-1 |
| MW: | 297.3 D |
ab 76,00 €
MMV390048
Artikelnummer: Cay41835-10
A P. vivax PI4K inhibitor (IC50 = 3.4 nM), active against P. falciparum (IC50 = 28 nM), decreases the blood levels of P. falciparum in P. falciparum-infected mice (ED90 = 0.57 mg/kg), reduces the hepatic levels of hypnozoite- and schizont-stage P. cynomolgi parasites in P. cynomolgi-infected rhesus monkeys at 20...
| Schlagworte: | 5-[4-(methylsulfonyl)phenyl]-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine |
| Anwendung: | Plasmodium vivax PI4K inhibitor |
| CAS | 1314883-11-8 |
| MW: | 393.4 D |
ab 107,00 €
AQW-051
Artikelnummer: Cay41851-10
A partial agonist of the alpha7 nAChR, induces calcium influx in GH3 cells expressing alpha7 nAChR (EC50 = 38.9 nM), improves learning and memory in the social recognition test in mice at 0.03 or 0.3 mg/kg, improves learning and memory in the Morris water maze test in rats at 3 mg/kg, increases the duration of...
| Schlagworte: | VQW-765, (3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane |
| Anwendung: | alpha7 nAChR partial agonist |
| CAS | 669770-29-0 |
| MW: | 294.4 D |
ab 104,00 €
DBCO acid
Artikelnummer: Cay41894-1
A copper-free click chemistry reagent, has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro, has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to...
| Schlagworte: | Dibenzocyclooctyne Acid, 11,12-didehydro-?-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid |
| Anwendung: | Copper-free click chemistry reagent |
| CAS | 1353016-70-2 |
| MW: | 305.33 D |
ab 43,00 €
4-Amino-D-phenylalanine
Artikelnummer: Cay41971-1
A synthetic amino acid and building block, has been used in the synthesis of CXCR4 antagonists. Formulation: A solid. InChI: InChI=1S/C9H12N2O2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,10-11H2,(H,12,13)/t8-/m1/s1. InChIKey: CMUHFUGDYMFHEI-MRVPVSSYSA-N. SMILES: OC([C@H](N)CC1=CC=C(C=C1)N)=O
| Schlagworte: | 4-NH2-D-Phe, p-Amino-D-phenylalanine, para-Amino-D-phenylalanine, (R)-2-amino-3-(4-aminophenyl)propanoic acid |
| Anwendung: | Synthetic amino acid, building block |
| CAS | 102281-45-8 |
| MW: | 180.2 D |
ab 132,00 €
DOTA-NOC (acetate)
Artikelnummer: Cay41975-1
A synthetic peptide, has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo. Formulation: A solid. InChI:...
| Schlagworte: | N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-... |
| Anwendung: | Synthetic peptide |
| MW: | 1455.7 D |
ab 137,00 €