Produkte von BPS Bioscience
Sonne, Meer und Wissenschaft: BPS Bioscience aus San Diego, Kalifornien fördert mit innovativen Lösungen für die Forschung neue wissenschaftliche Entdeckungen und die Entwicklung wirksamer Therapien. BPS ist ein Experte für rekombinante Proteine und Enzyme, Zelllinien, Virus-basierte Tools sowie für biochemische und zelluläre Assay-Systeme. Die hochwertigen Produkte und Services von BPS ermöglichen es Forschenden weltweit, biologische Entdeckungen in einer Vielzahl von Disziplinen voranzutreiben, darunter Epigenetik, Zellsignalübertragung, SARS-CoV-2, Immuntherapie, CRISPR und adoptive Zelltherapien.
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TROP2 Knockout HeLa Cell Line
Artikelnummer: BPS-82636
TROP2 Knockout HeLa Cell Line is a HeLa cell line in which human TROP2 (TACSTD2) has been genetically removed using CRISPR/Cas9 genome editing with a lentivirus encoding and stably expressing CRISPR/Cas9 gene and sgRNA (single guide RNA) targeting human TROP2. This cell line has been validated by genomic sequencing...
| Schlagworte: | TACSTD2, GA733-1, Cell surface glycoprotein Trop-2, Pancreatic carcinoma marker protein GA733-1, Tumor-associated calcium... |
| Anwendung: | TROP2 inhibitor/antibody negative control, TROP2 knockout phenotype studies |
| Spezies-Reaktivität: | human |
4.968,00 €
Lebrikizumab
Artikelnummer: BPS-82692-1
Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Ralpha/IL-13Ralpha1....
| Schlagworte: | Anti-IL13, Anti-NC30, Anti-IL-13, Anti-Interleukin-13, |
| Anwendung: | Immune cell signaling studies |
| Spezies-Reaktivität: | human |
| MW: | 49/23 kD |
ab 742,00 €
AS1517499
Artikelnummer: BPS-82693-1
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.1
| Schlagworte: | STAT6 inhibitor, |
| Anwendung: | Cell signaling pathway studies |
| CAS | 919486-40-1 |
| MW: | 397,86 D |
ab 389,00 €
PBMC Cytotoxicity Luciferase Assay Kit (Ramos)
Artikelnummer: BPS-82694
The PBMC Cytotoxicity Luciferase Assay Kit (Ramos) is designed to determine the cytotoxicity profile of PBMCs (Peripheral Blood Mononuclear Cells) towards the eGFP/Firefly Luciferase Ramos (RA 1) cell line. It uses the luminescent signal from the eGFP/Firefly Luciferase Ramos cell line to measure the number of live...
| Schlagworte: | Luciferase, Luciferin 4-monooxygenase, |
| Anwendung: | Luciferase-based cytotoxicity assays |
| Spezies-Reaktivität: | human |
4.635,00 €
Activin A: Activin RIIB[Biotinylated] Inhibitor Screening...
Artikelnummer: BPS-82695
The Activin A: Activin RIIB [Biotinylated] Inhibitor Screening Colorimetric Assay Kit is a colorimetric-based assay designed to measure the binding between human Activin A and Activin RIIB (receptor IIB), also known as ACVR2B, for screening and profiling applications. This kit comes with enough purified Activin A...
| Schlagworte: | ACVR2B, ACTR-IIB, EC=2.7.11.30, Activin receptor type-2B, Activin receptor type IIB, |
| Anwendung: | Binding inhibitor studies/screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.409,00 €
Sotorasib
Artikelnummer: BPS-82712-1
Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors1,2.
| Schlagworte: | KRAS G12C inhibitor, Sotorasib, AMG-510, |
| Anwendung: | Ras signaling, cancer therapy target |
| CAS | 2296729-00-3 |
| MW: | 560,59 D |
ab 367,00 €
USP9X Inhibitor Screening Assay Kit
Artikelnummer: BPS-82726
The USP9X Inhibitor Screening Assay Kit is a fluorogenic assay kit designed to measure the activity of the deubiquitinating (DUB) enzyme USP9X (ubiquitin specific peptidase 9 X-linked) for screenin82726-1g and profiling applications. The kit contains enough purified USP9X, Ubiquitinated-AMC substrate, and assay...
| Schlagworte: | hFAM, DFFRX, Fat facets in mammals, Ubiquitin thioesterase FAF-X, Deubiquitinating enzyme FAF-X, Fat facets... |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.123,00 €
eGFP/Firefly Luciferase MCF7 Cell Line
Artikelnummer: BPS-82730
eGFP/Firefly Luciferase MCF7 Cell Line is a MCF7 human breast mammary gland cell line engineered to express eGFP (enhanced green fluorescence protein) and Firefly luciferase driven by a CMV promoter. This cell line was generated by transduction with Firefly Luciferase-eGFP Lentivirus (#79980-P).
| Schlagworte: | Luciferase, Luciferin 4-monooxygenase, |
| Anwendung: | Cellular viability assays, ER-positive xenograft cell line, fluorescence/bioluminescence imaging |
| Spezies-Reaktivität: | human |
3.131,00 €
eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line
Artikelnummer: BPS-82732
eGFP/Firefly Luciferase BCMA Knockout MM.1S Cell Line is a MM.1S cell Line constitutively expressing firefly (Photinus pyralis) luciferase and the enhanced GFP (eGFP) cassette under the control of a CMV promoter, where BCMA (B-Cell Maturation Antigen, or CD269) has been genetically removed using CRISPR/Cas9 genome...
| Schlagworte: | Luciferase, Luciferin 4-monooxygenase, |
| Anwendung: | Cell killing assay control, CAR-T / CAR-NK cell B-cell target , CAR design optimization |
| Spezies-Reaktivität: | human |
11.023,00 €
USP22 Inhibitor Screening Assay Kit
Artikelnummer: BPS-82742
The USP22 Inhibitor Screening Assay Kit is a fluorogenic assay kit designed to measure the activity of the deubiquitinating (DUB) enzyme USP22 (ubiquitin specific peptidase 22) for screening and profiling applications. The kit contains enough purified USP22, Ubiquitinated-AMC substrate, and assay buffer for 100...
| Schlagworte: | USP22, KIAA1063, Ubiquitin thioesterase 22, Deubiquitinating enzyme 22, Ubiquitin carboxyl-terminal hydrolase 22,... |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
1.123,00 €
Vandortuzumab
Artikelnummer: BPS-82750-1
Vandortuzumab is a CHO-expressed humanized antibody targeting STEAP1. Vandortuzumab has a huIgG1 type heavy chain and a hukappa type light chain, with a predicted molecular weight (MW) of 148.74 kDa.
| Schlagworte: | Anti-STEAP1, Anti-PRSS24, Anti-STEAP1 protein, Anti-Six-transmembrane epithelial antigen of prostate 1, |
| Anwendung: | Cancer therapy targets |
| Spezies-Reaktivität: | human |
| MW: | 148,87 kD |
ab 827,00 €
Chemi-Verse(TM) PDGFRalpha (D842Y) Kinase Assay Kit
Artikelnummer: BPS-82751
The Chemi-Verse(TM) PDGFRalpha (D842Y) Kinase Assay Kit is designed to measure PDGFRalpha (platelet-derived growth factor receptor A) (D842Y) tyrosine kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough...
| Schlagworte: | CD140a, PDGFRA, PDGFR2, PDGFR-2, EC=2.7.10.1, PDGFR-alpha, PDGF-R-alpha, CD140a antigen, CD140 antigen-like family member... |
| Anwendung: | Enzyme kinetics, small molecule inhibitor screening, drug discovery, HTS |
| Spezies-Reaktivität: | human |
975,00 €
