Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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PROTAC SMARCA2/4-degrader-9
Item number: TGM-T89170-10mg
Description: PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in MV411 and A549 cells, with a DC50 of less than 100 nM, and degrades SMARCA4 in MV411 with a similar DC50. Smiles:...
| MW: | 914.13 D |
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BVB808
Item number: TGM-T89180-100mg
Description: BVB808 (NVP_BVB808) is a selective inhibitor of JAK2, exhibiting approximately 10 times greater selectivity for JAK2 compared to other members of the JAK family (such as JAK1, JAK3, or TYK2) in vitro. By inhibiting the activation of JAK2, BVB808 reduces the phosphorylation of STAT5, thereby blocking the...
| Keywords: | NVP_BVB808 |
| MW: | 533.62 D |
From 1,440.00€
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KRAS inhibitor-24
Item number: TGM-T89191-100mg
Description: KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM. Target: Ras, Kras. Smiles:...
| MW: | 641.15 D |
From 2,295.00€
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EGFR-IN-121
Item number: TGM-T89192-100mg
Description: EGFR-IN-121 (compound 15) acts as a dual inhibitor for EGFR and VEGFR-2, with IC50 values of 84 nM and 3.5 nM, respectively. Smiles: O=C(OC(C)C)C1=C(NC(=O)NC1C2=CC=C(OCC=3C=CC=CC3)C(OC)=C2)C
| MW: | 410.46 D |
From 1,440.00€
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AZ683
Item number: TGM-T89203-100mg
Description: AZ683 is an effective selective inhibitor of the 3-amino-4-anilinoquinoline CSF1R, demonstrating a high affinity for CSF1R (Ki=8 nM, IC50=6 nM). It also possesses favorable oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) tracer for the colony stimulating factor 1...
| MW: | 441.47 D |
From 1,440.00€
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CDK7-IN-30
Item number: TGM-T89204-100mg
Description: CDK7-IN-30 (Compound 22) is an inhibitor of CDK7 with an IC50 value of 7.21 nM, effectively inhibiting the phosphorylation of RNA polymerase II and CDK2. It can induce cell apoptosis (apoptosis) and exhibits anticancer activity, making it useful for cancer research. Smiles:...
| MW: | 466 D |
From 1,440.00€
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Sp-cGMPS
Item number: TGM-T89208-100mg
Description: Sp-cGMPS serves as an activator for cGMP-dependent protein kinases (PKGs). It is frequently utilized in research related to cardiovascular diseases. Smiles: O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(S)O4)[H])[H])NC(N)=N1
| MW: | 361.27 D |
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ZG-2291
Item number: TGM-T89209-100mg
Description: ZG-2291 is a selective inhibitor targeting FIH (hypoxia-inducible factor inhibitor) with oral activity. It selectively inhibits FIH by binding to it and inducing a conformational flip in a catalytically crucial tyrosine, without affecting other 2OG oxidases of the JmjC subfamily. ZG-2291 promotes...
| MW: | 373.75 D |
From 1,440.00€
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Serotonin azidobenzamidine
Item number: TGM-T89218-10mg
Description: Serotonin azidobenzamidine, an aryl azide derivative of 5-hydroxytryptamine, competitively inhibits the uptake of [3H]5-hydroxytryptamine by rat cortical synaptosomes under dark conditions, with a Ki of 130 nM. Smiles: [N-]=[N+]=NC1=CC=C(C=C1)C(=N)NCCC2=CNC=3C=CC(O)=CC32
| Keywords: | SABA |
| MW: | 320.35 D |
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PARP1-IN-28
Item number: TGM-T89219-10mg
Description: PARP1-IN-28 (compound 1) is a PARP1 inhibitor. Smiles: O=C(NC)C1=NC=C(C=C1)N2CCN(CC=3C=NC=4C=C(C(=O)NC4C3)C5CC5)CC2
| MW: | 418.49 D |
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Murexide
Item number: TGM-T89223-10mg
Description: Murexide (Ammonium purpurate) is utilized as an indicator in complexometric titration for determining water hardness. Target: Others. Smiles: O=C1NC(/C(C(N1)=O)=N/C2C([N-]C(NC2=O)=O)=O)=O.[NH4+]
| Keywords: | Ammonium purpurate |
| MW: | 284.19 D |
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Selenosemicarbazide
Item number: TGM-T89224-10mg
Description: Selenosemicarbazide (Hydrazinecarboselenoamide) exhibits antibacterial properties, effectively inhibiting B. subtilis, S. aureus, Klebsiella pneumoniae, Sarcina lutea, and Mycobacterium tuberculosis. Additionally, it forms complexes with metal ions, demonstrating antitumor activity against cancer cells....
| Keywords: | Hydrazinecarboselenoamide |
| MW: | 138.03 D |
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