Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with universities, research institutes and industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr. Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
More information at: www.adipogen.com/synkinase
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Merck-5
Item number: SYN-1054-M001
Soluble in DMSO. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4...
| Keywords: | Pyridone 6 |
| Application: | JAK / Tyk2 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309,3 D |
From 300.00€
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Vandetanib
Item number: SYN-1090-M005
Soluble in DMSO or ethanol. Vandetanib is a tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR, IC(50) of 40nM) and the epidermal growth factor receptor (EGFR). Target: EGFR - VEGFR2 , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | ZD6474, Zactima, Vandetanib |
| Application: | EGFR / VEGFR2 inhibitor |
| CAS | 443913-73-3 |
| MW: | 475,4 D |
From 79.00€
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R788 disodium salt
Item number: SYN-1122-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | Fostamatinib, Tamatinib fosdium, FosD, R-788 |
| Application: | Syk inhibitor |
| CAS | 1025687-58-4 |
| MW: | 624,5 D |
From 139.00€
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Bayer-18
Item number: SYN-1130-M001
Soluble in DMSO. Bayer-18 is a selective TYK2 inhibitor, with an IC(50) of 18.7nM on TYK2 as measured by TYK2 HTRF assays. The compound shows 1000 fold selectivity against JAK2, CDK and KDR kinases in similar HTRF assays. Target: TYK2 , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | Bayer18 |
| Application: | TYK2 inhibitor |
| CAS | 1251752-12-1 |
| MW: | 390,5 D |
From 250.00€
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Bafetinib
Item number: SYN-1179-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC(50) values of 5.8nM and 19nM, respectively.
| Keywords: | NS-187, INNO-406 |
| Application: | Bcr-Abl / Lyn inhibitor |
| CAS | 859212-16-1 |
| MW: | 576,6 D |
From 132.00€
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Canertinib
Item number: SYN-1030-M010
Soluble in DMSO or ethanol. Canertinib is an orally bio-available EGFR inhibitor with potential anti-neoplastic and radio-sensitizing activities. It has IC(50) values of 1.5nM and 9.0nM against EGFR and ErbB2 respectively, with no activity against PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Target: EGFR , Kinase Group:...
| Keywords: | CI1033, PD-183805 |
| Application: | EGFR inhibitor |
| CAS | 267243-28-7 |
| MW: | 486 D |
From 66.00€
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KU-0063794
Item number: SYN-1050-M005
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. KU0063794 is a highly specific inhibitor of the mammalian target of rapamycin (mTOR). It inhibits both mTORC1 and mTORC2 with an IC(50) of approximately 10nM. Target: mTOR , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
| Keywords: | KU0063794 |
| Application: | mTOR inhibitor |
| CAS | 938440-64-3 |
| MW: | 465,6 D |
From 92.00€
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PIK-75
Item number: SYN-1067-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-75 is a PI3K inhibitor displaying selectivity for the p110alpha isoform (IC(50) of 6nM). PIK-75 blocks the phosphorylation of PKB induced by insulin. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Keywords: | PIK75 |
| Application: | PI3K-beta inhibitor |
| CAS | 372196-67-3 |
| MW: | 452,3 D |
From 66.00€
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Afatinib
Item number: SYN-1100-M001
Soluble in DMSO or ethanol. Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines...
| Keywords: | Tovok, BIBW-2992 |
| Application: | EGFR / HER2 inhibitor |
| CAS | 439081-18-2 |
| MW: | 486 D |
From 106.00€
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GLPG0634
Item number: SYN-1158-M001
Soluble in DMSO. GLPG0634 is a novel and specific inhibitor of JAK1 and JAK2 with IC(50) of 10nM and 28nM respectively measured by in vitro kinase assays (ATP 2µM). In particular GLPG0634, while being a potent inhibitor of JAK1 and JAK2 does not inhibit TYK2 or JAK3, and GLPG0634 exhibits a dramatically improved in...
| Keywords: | GLPG-0634, Filgotinib |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1206161-97-8 |
| MW: | 425,5 D |
From 250.00€
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LEE011
Item number: SYN-1213-M001
Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...
| Keywords: | LEE-011, Ribociclib |
| Application: | CDK4/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434,5 D |
From 66.00€
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Selonsertib Hydrochloride
Item number: SYN-1229-M001
Solid. Soluble in DMSO or ethanol. LY2784544 is a potent JAK2 inhibitor with IC(50) of 3nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.
| Keywords: | LY-2784544 |
| Application: | JAK2 inhibitor |
| CAS | 1448428-05-4 |
| MW: | 469,9 D |
From 119.00€
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