Products from SYNkinase

SYNkinase

SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with Universities, Research Institutes and Industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.

More information at: synkinase.com

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CX-4945
CX-4945

Item number: SYN-1109-M001

Soluble in DMSO or ethanol. CX-4945 is a first-in-class, orally active, potent and selective inhibitor of the protein kinase CK2, with an IC(50) of 1nM.
Keywords: CX4945
Application: CK2 inhibitor
CAS 1009820-21-6
MW: 349,8 D
From 132.00€ *
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LY-294002
LY-294002

Item number: SYN-1108-M005

Soluble in DMSO or ethanol. LY294002 is a selective and reversible PI3K inhibitor with an IC(50) range of 0.5 - 1µM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
Keywords: LY-294002
Application: PI3K inhibitor
CAS 154447-36-6
MW: 307,3 D
From 66.00€ *
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Regorafenib
Regorafenib

Item number: SYN-1169-M100

Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
Keywords: BAY-73-4506
Application: VEGFR2 / RET / Raf-1 inhibitor
CAS 755037-03-7
MW: 482,8 D
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Dasatinib
Dasatinib

Item number: SYN-1036-M001

Soluble in DMSO or ethanol. The BCR-ABL oncogene triggers intracellular signaling, activating multiple transduction cascades, promoting the growth, proliferation and survival of hematopoietic cells. BCR-ABL plays a role in defective DNA repair, alteration of cellular adhesion and inhibition of apoptosis....
Keywords: BMS-354825, Sprycel
Application: BCR-ABL / c-KIT / Src inhibitor
CAS 302962-49-8
MW: 488 D
From 66.00€ *
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CX-5461
CX-5461

Item number: SYN-3031-M001

Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Keywords: Chantix, Champix
Application: RNA polymerase I inhibitor
CAS 1138549-36-6
MW: 513.6 D
From 119.00€ *
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Selumetinib
Selumetinib

Item number: SYN-1016-M005

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. Selumetinib (AZD6244) is a second-generation, orally available, potent and selective ATP non-competitive inhibitor of MEK 1/2. In direct assays, AZD6244 selectively inhibits purified active MEK1 and MEK2 with an IC(50) of 14nM, and AZD6244 has reported IC(50)...
Keywords: AZD6244, ARRY-142886
Application: MEK 1/2 inhibitor
CAS 606143-52-6
MW: 457,7 D
From 106.00€ *
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(R)-BI-2536
(R)-BI-2536

Item number: SYN-1019-M001

Soluble in DMSO, Ethanol. Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple...
Keywords: (R)-BI2536
Application: PLK1 inhibitor
CAS 755038-02-9
MW: 521,7 D
From 106.00€ *
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TAE-684
TAE-684

Item number: SYN-1159-M001

Soluble in DMSO or ethanol. TAE684 is a potent and selective ALK inhibitor with an IC(50) of 3nM. It is 100-fold more sensitive for ALK over InsR. Target: ALK , Kinase Group: RTK , Substrate: Tyrosine
Keywords: NVP-TAE684
Application: ALK inhibitor
CAS 761439-42-3
MW: 614,2 D
From 119.00€ *
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GSK-A1
GSK-A1

Item number: SYN-1219-M005

Solid. Soluble in DMSO. GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory...
Keywords: 5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, GSKA1
Application: Potent PI4KA inhibitor
CAS 1416334-69-4
MW: 574,6 D
From 158.00€ *
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AST-487
AST-487

Item number: SYN-1210-M001

Slightly soluble (< 1mg/mL) in DMSO. AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. Target: Flt3 , Kinase Group: TK , Substrate: Tyrosine
Keywords: AST487
Application: Flt3 inhibitor
CAS 630124-46-8
MW: 529,6 D
From 119.00€ *
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LY2801653
LY2801653

Item number: SYN-1222-M005

Solid. Soluble in DMSO. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R and other oncoproteins. It displays anti-tumour activities in mouse xenograft models. In vitro, LY2801653 has an IC50 for inhibition of MET phosphorylation between 35.2-59.2nM. LY2801653 was...
Keywords: LY-2801653,...
Application: Multi-kinase inhibitor
CAS 1206799-15-6
MW: 552,5 D
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Erlotinib hydrochloride
Erlotinib hydrochloride

Item number: SYN-1039-M001

Soluble in DMSO. Slightly soluble ( 1000-fold more sensitive for EGFR than for c-Src or v-Abl. Target: EGFR , Kinase Group: RTK , Substrate: Tyrosine
Keywords: OSI774, CP-358774, Tarceva, NSC718781
Application: EGFR inhibitor
CAS 183319-69-9
MW: 429,9 D
From 66.00€ *
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