Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with universities, research institutes and industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr. Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
More information at: www.adipogen.com/synkinase
No results were found for the filter!
GSK-F1
Item number: SYN-1220-M001
Solid. Soluble in DMSO. GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for...
| Keywords: | 5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulf... |
| Application: | Potent PI4KA inhibitor |
| CAS | 1402345-92-9 |
| MW: | 603,5 D |
From 158.00€
*
Regorafenib
Item number: SYN-1169-M100
Soluble in DMSO or ethanol. Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR beta, Kit, RET and Raf-1 with IC(50) values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. Target: VEGFR , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | BAY-73-4506 |
| Application: | VEGFR2 / RET / Raf-1 inhibitor |
| CAS | 755037-03-7 |
| MW: | 482,8 D |
Please request pricing for this article.
CX-5461
Item number: SYN-3031-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
| Keywords: | Chantix, Champix |
| Application: | RNA polymerase I inhibitor |
| CAS | 1138549-36-6 |
| MW: | 513.6 D |
From 119.00€
*
(R)-BI-2536
Item number: SYN-1019-M001
Soluble in DMSO, Ethanol. Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple...
| Keywords: | (R)-BI2536 |
| Application: | PLK1 inhibitor |
| CAS | 755038-02-9 |
| MW: | 521,7 D |
From 106.00€
*
TAE-684
Item number: SYN-1159-M001
Soluble in DMSO or ethanol. TAE684 is a potent and selective ALK inhibitor with an IC(50) of 3nM. It is 100-fold more sensitive for ALK over InsR. Target: ALK , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | NVP-TAE684 |
| Application: | ALK inhibitor |
| CAS | 761439-42-3 |
| MW: | 614,2 D |
From 119.00€
*
GSK-A1
Item number: SYN-1219-M001
Solid. Soluble in DMSO. GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory...
| Keywords: | 5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, GSKA1 |
| Application: | Potent PI4KA inhibitor |
| CAS | 1416334-69-4 |
| MW: | 574,6 D |
From 158.00€
*
LY2801653
Item number: SYN-1222-M005
Solid. Soluble in DMSO. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R and other oncoproteins. It displays anti-tumour activities in mouse xenograft models. In vitro, LY2801653 has an IC50 for inhibition of MET phosphorylation between 35.2-59.2nM. LY2801653 was...
| Keywords: | LY-2801653,... |
| Application: | Multi-kinase inhibitor |
| CAS | 1206799-15-6 |
| MW: | 552,5 D |
From 106.00€
*
Erlotinib hydrochloride
Item number: SYN-1039-M001
Soluble in DMSO. Slightly soluble ( 1000-fold more sensitive for EGFR than for c-Src or v-Abl. Target: EGFR , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | OSI774, CP-358774, Tarceva, NSC718781 |
| Application: | EGFR inhibitor |
| CAS | 183319-69-9 |
| MW: | 429,9 D |
From 66.00€
*
GW-441756
Item number: SYN-1044-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner. Target: TrkA , Kinase Group: RTK , Substrate: Tyrosine
| Keywords: | GW441756 |
| Application: | TrkA inhibitor |
| CAS | 504433-23-2 |
| MW: | 275,3 D |
From 79.00€
*
PF-4618433
Item number: SYN-1163-M001
Soluble in DMSO. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent...
| Keywords: | PF4618433 |
| Application: | PYK2 inhibitor |
| CAS | 1166393-85-6 |
| MW: | 445,5 D |
From 250.00€
*
BKM-120
Item number: SYN-1200-M005
Soluble in DMSO or ethanol. NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kalpha Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks Target: PI3K , Kinase Group: Lipid Kinase ,...
| Keywords: | NVP-BKM120 |
| Application: | PI3K inhibitor |
| CAS | 944396-07-0 |
| MW: | 410,4 D |
From 79.00€
*
GSK-2606414
Item number: SYN-1201-M001
Soluble in DMSO or ethanol. GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC(50) of 0.4nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed Target: PERK , Kinase Group: Other , Substrate: Serine-Threonine
| Keywords: | GSK-2606414 |
| Application: | EIF2AK3 / PERK inhibitor |
| CAS | 1337531-36-8 |
| MW: | 451,4 D |
From 119.00€
*