Catalogs from Cayman Chemical
Cayman Currents: Lipid Nanoparticles
Lipid Nanoparticles (LNPs) are primed to revolutionize modern medicine. This technology has immense possibilities to evolve beyond infectious disease to reach targets once considered undruggable and treat a near infinite number of conditions. With LNPs, it is now possible to move beyond traditional small molecules into nucleic acid-based therapies. With the right design, it should be possible to engineer LNPs to suit any number of payloads for vaccination, protein replacement therapy, and therapeutic gene knockdown. But the field is still in its infancy, and there are a number of challenges yet to overcome to unlock the full potential of LNPs. Released October 2023.
Cayman Chemical: Oxidative Stress Guide
Oxidative stress occurs when there is an imbalance between the production of chemically reactive species such as reactive oxygen, nitrogen, and sulfur species (ROS, RNS, RSS) and antioxidant defense mechanisms. Uncontrolled oxidation can disrupt redox signaling and cause injury to cellular components like lipids, proteins, and nucleic acids, resulting in irreparable damage and eventual cell death. Oxidative stress can be evaluated directly by measuring reactive species or indirectly by the associated damage to lipids, proteins, and nucleic acids. Although direct measurement of these reactive species is desirable, indirect methods are often more reliable due to the relative stability of damage markers on biomolecules compared to the transient nature of reactive species. Multiple biomarkers of oxidative damage have been identified for different macromolecules (e.g., proteins, lipids, and DNA/RNA). Use this guide to find the right marker of oxidative stress and detection tool for your application. Released September 2022.
Cayman Chemical: A Guide to Lipid Nanoparticle Formulation
The success of mRNA-based COVID-19 vaccines could not have been possible without decades of research on lipid-based drug delivery (LBDD). LBDD systems are highly versatile and have been used to deliver various bioactive molecules to targeted cells and tissues. LBDD has several advantages over conventional drug delivery methods, including increased drug stability, bioavailability, and distribution. Lipid nanoparticles (LNPs) are a significant advancement for the delivery of oligonucleotide-based therapeutics. Oligonucleotides encapsulated within LNPs are protected from enzymatic degradation during the delivery process and are efficiently delivered to cells, where the therapeutic cargo is released. Use this guide to learn about LBDD systems, the cargoes they deliver, and to explore basic concepts and procedures for the preparation of LNPs. If you are working on LBDDs, check out all related products from our partner Cayman Chemical. Released June 2022.
Cayman Chemical: Cell Death Mechanisms and Detection Tools
Cell death occurs for both physiological and pathological reasons. Varying modes of death are either programmed to safely remove healthy cells that are no longer useful or to stimulate an inflammatory response to clear cells that are useful but no longer healthy. To distinguish among the multiple ways a cell can self-destruct, distinct morphological changes, triggers, and biochemical hallmarks are monitored. However, crosstalk between certain modes of death can also occur, making it important to examine more than one readout when identifying the types of cell death in your experiments. Use this guide to learn about the tools available to investigate multiple molecular pathways and cell death markers to help you determine the cell death mechanism(s) occurring under your experimental circumstances. Released September 2021.
Cayman Currents: Long COVID
In This Issue:
- Research Tools for Long COVID Syndrome
- Host Immune Response: Autoimmunity
- Host Immune Response: Inflammation
- Mitochondrial Dysfunction in Post-Viral Syndromes
Released Fall 2021.
Cayman Currents: Phytocannabinoids
In This Issue:
- Cannabis: Our Key to the Endocannabinoid System
- Phytocannabinoid Testing Standards
- Degradants Formed During Phytocannabinoid Processing
- Basic Research Cannabinoids
- Phytocannabinoid Reference Table
- International Regulation & Control of Hemp & Cannabinoids
Released December 2020 - Updated July 2021.
Cayman Currents: Antiviral Strategies for Emerging Infectious Diseases
In This Issue:
- Using Existing Therapeutics Against SARS-CoV-2
- SARS-CoV-2 Research Tools
- Antiviral Compounds & Libraries
- Special Feature: Viral Infection Life Cycle
- Vaccine Development Considerations
- Host Immune Response
- Immunopeptidome Profiling Services
Released July 2020 - Updated December 2020.
Cayman Currents: Proven Solutions For Lipid Analysis
In This Issue:
- Cayman's Historic Lipid Research Contributions
- Eicosanoid Analysis: Thoughts on Internal Standards and Reference Standards
- Specialized Pro-Resolving Mediators and Eicosanoids: A Preferred Solid-Phase Extraction Protocol from Tissues and Biological Fluids
- Lipidomics Services
- Resources for Lipid Researchers
- Common MRM Transitions
Released October 2019.
Cayman Currents: Fatty Liver Disease (NAFLD/NASH)
In This Issue:
- Targeting Insulin Resistance for the Treatment of NASH
- Tools to Study NAFLD/NASH
- Pathophysiology of NAFLD Infographic
- A guide to PPAR function and structure
- Oxidative Stress, Inflammation, and Apoptosis Targets
Released January 2019.
Cayman Currents: Ferroptosis: A New Form of Cell Death
In This Issue:
- The Ferroptosis Pathway: Structure, Function, and Modulation
- Ferroptosis Inducers
- Lipid Peroxidation
- Ferroptosis Inhibitors
- Oxytosis vs. Ferroptosis; What's In a Name?
Released October 2018.
Cayman Currents: Innate Immune Signaling: cGAS/STING
In This Issue:
- cGAS and STING Nucleic Acid Sensors: Potential Therapeutic Targets in Innate Immunity and Oncology
- Cytosolic DNA Sensing
- Type I Interferon Activation
- Interferon Gene Stimulation
- NF-κB Activation
Released July 2018.
Cayman Currents: Epigenetics
In This Issue:
- Bromodomain Targeting with PROTACs
- Inhibitors: Writers, Erasers, and Readers
- Researcher Spotlight: Peter J. Brown, Ph.D.
- Assay Kits: Readers, Writers, and Erasers
- Antibodies
- Proteins: Readers, Writers, and Erasers
Released April 2017.
Cayman Currents: Neutrophil Biology
In This Issue:
- Neutrophil Defensive NETworks
- NET Quantification
- NET Components: Histones
- Antibodies for NET Research
- Neutrophil Isolation and Function
- PAD Reagents
Released October 2016.
Cayman Currents: Bioenergetics
In This Issue:
- Mitochondria and Cellular Homeostasis: Beyond ATP Synthesis
- Evaluating Mitochondrial Toxicity
- MitoCheck® Assays
- Oxygen Consumption Rate Assays
- Glycolysis
- Oxidative Stress
Released June 2016.