Catalogs from BPS Bioscience
Neuroscience Research Tools
Neuroscience research plays a pivotal role in our understanding of the human brain and its neural system, making it a crucial field with far-reaching implications. By exploring the structure, function, and development of the nervous system, neuroscience provides insights into the fundamental mechanisms underlying how our brains function. This knowledge is essential for advancing our comprehension of neurological disorders, mental health conditions, brain malignancies, and brain-related injuries, leading to improved diagnostic techniques, novel therapeutic interventions, and more personalized treatments. Discover BPS Bioscience's selection of active proteins, assay kits, cell lines and neutralizing antibodies for your neuroscience research. Released February 2024.
DNA Damage Response Research Tools
DNA damage, resulting in base mismatches, bulky adducts, cross-links, single strand breaks, or double strand breaks, can occur from a variety of exogenous and endogenous mechanisms. In response, mammalian cells employ an array of mechanisms to repair the damaged DNA. Repair pathways can also trigger cell cycle blockade, stress responses, and apoptosis. BPS Bioscience has a broad selection of tools for your work on DNA damage and repair including PARPtrapTM assay kits, active proteins, reporter lentiviruses and a cell-based PARylation assay. Released February 2024.
CAR-T Cell Tools for Engineering the Immune System
The development of Chimeric Antigen Receptor (CAR)-expressing T cells has made significant progress in the treatment of some types of cancer, with potential for applications in transplantation and chronic inflammation as well. More work is required to improve and expand therapies, and to limit harmful sideeffects. The future is bright for CAR-T research, and our partner BPS Bisoscience continues to develop unique cell lines and other tools to help researchers create, evaluate, and enhance CAR-T cells for the improvement of human health. Updated March 2023.
Custom Services to Advance Drug Discovery
Customized solutions to advance your research: BPS Bioscience offers a wide range of service capabilities for a variety of research applications, focusing on drug discovery. Their expert scientists provide fast, reliable services to clients world-wide, ranging from top pharmaceutical and vaccine companies to startup biotech labs. The company's dedication to producing high quality custom products will enable your next discoveries. Updated March 2023.
Virus-based Tools for Drug Discovery
Optimized viral options: virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection. BPS Bioscience has designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more. Updated March 2023.
Coronavirus Research Tools
The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus, has ravaged the globe, infecting over 600 million people and causing over 6.5 million deaths as of Fall 2022. While the latest vaccines have proven effective at reducing hospitalizations and deaths, new variants will likely continue to emerge and spread, requiring further research and advancements in prevention, diagnosis, and patient care. BPS Bioscience supports end-to-end research and development efforts from protein design to assay kit development and screening services. Their proven innovative solutions have already been utilized by pharma and vaccine developers worldwide. Updated March 2023.
CRISPR-Cas9 Tools & Services for Gene Editing
CRISPR-Cas9 is a technique used for genome editing that is adapted from bacterial antiviral immune mechanisms. Bacteria capture and store DNA fragments from invading viruses within a region of their genome, and these CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) guide sequences help detect and protect the bacteria from future infections. When the CRISPR guide sequences detect an invading virus or DNA whose sequence is complementary to the CRISPR guide, the Cas9 (CRISPR-associated protein 9) nuclease is recruited to specifically cleave the invading DNA, resulting in its degradation. Updated March 2023.
Kinase Research Tools
Protein phosphorylation regulates a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein, lipid, nucleotide, and carbohydrate kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate. They are now key therapeutic targets across many disease areas. Updated March 2023.
Immunotherapy Tools for Drug Discovery
Immunotherapeutic approaches to treat cancer or other diseases holds exceptional promise for eradicating or controlling diseases. Some approaches, including immune checkpoint blockade, CAR-T cells, CAR-NK cells, cytokines, and antibodies have already proven effective in the clinic. Our partner BPS Bioscience offers a comprehensive selection of immunotherapy products, featuring novel tools, such as bispecific and trispecific antibodies, bioactive proteins, biochemical and cellular bioassay systems, recombinant cell lines, and virus-based tools, as well as screening and profiling services to test your compounds. Updated March 2023.
Epigenetics Drug Discovery Solutions
The field of epigenetics refers to the control or modulation of gene expression that produces a specific phenotype or trait without directly changing DNA sequences. Epigenetic control can occur by modifying DNA, RNA, or by modulating the proteins that bind to DNA, particularly histone proteins. Epigenetic modifications start early in embryonic development and continue as organisms age and are strongly influenced by environmental factors. Epigenetic mechanisms are now important therapeutic drug targets spanning several disease areas, including multiple cancers, myelodysplastic syndromes, autoimmunity, neurodegeneration, and more. Updated March 2023.
Cell Systems for Drug Discovery
In order to evaluate drug candidates, researchers need a clear understanding of the activity of the molecules of interest at a cellular level. Biochemical assays and binding kinetics can provide molecular dynamics, but intact cellular assays are the requisite next level to clearly realize how drug candidates exert effects in the context of the cell. The 200+ cell lines, primary cells, iPSC-derived cells, and cell-based assay kits by our partner BPS Bioscience provide robust cellular systems for testing and verification. These cell products are complemented by the company's media reagents, including thaw, growth, assay, and freezing media optimized to each cell type, which together with their convenient luciferase detection systems, yield complete cell systems for research. Updated March 2023.