Prostaglandin F2alpha-d4

Prostaglandin F2alpha-d4 (PGF2alpha-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF2alpha (Cay-16010) by GC- or LC-mass spectrometry. PGF2alpha is a widely distributed prostaglandin occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exerts potent luteolytic activity. PGF2alpha exhibits its receptor mediated physiological activity at 50-100 nM. Maximal ovine myometrial contraction can be achieved at 125 nM PGF2alpha in vitro.Formal Name: 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. CAS Number: 34210-11-2. Synonyms: Dinoprost-d4, PGF2alpha-d4. Molecular Formula: C20H30D4O5. Formula Weight: 358.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a), DMF: >100 mg/ml (from PGF2a), DMSO: >100 mg/ml (from PGF2a), Ethanol: >100 mg/ml (from PGF2a), PBS pH 7.2: >10 mg/ml (from PGF2a). SMILES: O[C@@H]1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1/i5D2,8D2. InChi Key: PXGPLTODNUVGFL-MKIWGZNBSA-N.