Products from LKT Laboratories
LKT Laboratories, Inc., in St. Paul, Minnesota, is a research and development company focussing on the synthesis, purification and isolation of small molecules. Established in 1989, LKT Labs produces and markets unique (bio-)chemicals for all types of life science research, especially for the fields of cancer and neuroscience. The products include protein kinase inhibitors as well as ion channel modulators and are used for various research applications.
More information at: www.lktlabs.com
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Nitisinone
Item number: LKT-N3476.50
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
| Keywords: | NTBC, orfadin |
| Application: | 4-hydroxyphenylpyruvate dioxygenase inhibitor |
| CAS | 104206-65-7 |
| MW: | 329.23 D |
From 80.00€
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Staurosporine
Item number: LKT-S7600.1
A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
| Keywords: | AM-2282, STS |
| Application: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
From 60.00€
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Carmustine
Item number: LKT-C0173.100
Carmustine is an antitumor agent.
| Keywords: | BCNU, bis-chloroethylnitrosourea |
| Application: | Anticancer agent |
| CAS | 154-93-8 |
| MW: | 214,05 D |
From 99.00€
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Paclitaxel (Semi-synthetic)
Item number: LKT-P0093.100
A natural diterpenoid originally isolated from the stem bark of Taxus brevifolia. It promotes the assembly of stable microtubules and inhibits the disassembly process of microtubules to tubulin by calcium ions and by low temperature. Taxol was shown to have activity against cancers, such as P388 and L1210 leukemia,...
| Keywords: | Taxol |
| Application: | Chemopreventive agent |
| CAS | 33069-62-4 |
| MW: | 853,9 D |
From 119.00€
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R,S-Sulforaphane
Item number: LKT-S8044.50
R,S-Sulforaphane is a synthetic version of the naturally occurring compound, R-sulforaphane, from Broccoli. It is a racemic mixture of both the R and S isomers. At room temperature, it is a very slightly yellowish viscous liquid. Its isothiocyanate group reacts with protic solvents such as water and ethanol to form...
| Application: | Chemopreventive agent |
| CAS | 4478-93-7 |
| MW: | 177,29 D |
From 246.00€
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Celecoxib
Item number: LKT-C1644.1
Celecoxib is a selective COX 2 inhibitor.
| Application: | COX-2 inhibitor |
| CAS | 169590-42-5 |
| MW: | 381,37 D |
From 156.00€
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GSK1120212
Item number: LKT-G7440.5
GSK1120212 inhibits MEK1/2 and is currently in clinical trials as a potential treatment for melanoma. GSK1120212 exhibits anticancer chemotherapeutic activity, upregulating p27 expression and inhibiting growth in colorectal cancer cells and suppressing tumor growth in colorectal cancer xenografts.
| Keywords: | Trametinib, JTP-74057 |
| Application: | MEK1/2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.39 D |
From 104.00€
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Methysticin
Item number: LKT-M1679.10
One of the main components in kava kava extract. It has anxiolytic effect and neuroprotective property.
| Application: | Metabolic studies |
| CAS | 495-85-2 |
| MW: | 274,27 D |
From 370.00€
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Spiramycin
Item number: LKT-S6232.5
A macrolide antibiotic. It has been shown to decrease the replication index of humanlymphocytes.
| Keywords: | SPM, RP-5337 |
| Application: | Antibiotic, macrolide |
| CAS | 8025-81-8 |
| MW: | 842,05 D |
From 137.00€
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MG132
Item number: LKT-M2400.5
MG-132 is a proteasome inhibitor that exhibits anti-fibrotic and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive...
| Keywords: | MG-132 |
| Application: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 475.62 D |
From 180.00€
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Clozapine N-oxide
Item number: LKT-C4759.25
Metabolite of clozapine. It is 5-HT2 serotonin receptor antagonist.
| Application: | 5-HT2 serotonin receptor antagonist |
| CAS | 34233-69-7 |
| MW: | 342,82 D |
From 261.00€
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Pepstatin
Item number: LKT-P1761.25
An inhibitor of acid proteases isolated from streptomyces. It has been shown to induce contractile effects on rat aorta rings.
| Keywords: | Pepstatin A |
| Application: | Aspartyl Protease inhibitor |
| CAS | 26305-03-3 |
| MW: | 685,89 D |
From 120.00€
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