21 products were found matching "K06172"!

Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the...

Anti-APH1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with APH1 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...

Anti-APH1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with APH1 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. APH1A encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Anterior pharynx defective 1 homolog A Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins...

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin,...

APH1A also known as Anterior pharynx-defective 1, is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. The gamma-secretase complex is required for the intramembrane proteolysis of APP (amyloid-beta...

APH1A also known as Anterior pharynx-defective 1, is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. The gamma-secretase complex is required for the intramembrane proteolysis of APP (amyloid-beta...

E2012 is a modulator of gamma-secretase. It selectively inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta) over Notch cleavage to its signaling effector Notch intracellular domain (NICD), processes both mediated by gamma-secretase, when used at a concentration of 1 µM in luciferase...

WB 1:500 - 1:2000. Protein function: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021,...