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Item number: Cay17729-5
Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: | Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester |
Application: | Ferroptosis inhibitor |
CAS | 347174-05-4 |
MW: | 262.4 D |
From 50.00€ *
Item number: Cay703102-480
Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Keywords: | EC=1.11.1.9, GPX |
Application: | GTx activity detection |
From 357.00€ *
Item number: Cay703202-96
Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Keywords: | GR, GSR, GLUR, GRase, EC=1.8.1.7 |
Application: | GR activity detection |
282.00€ *
Item number: Cay705002-100
Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: | LPO quantification |
303.00€ *
Item number: Cay705003-96
Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: | LPO quantification |
744.00€ *
Item number: Cay14953-100
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell-permeable derivative of GSH that undergoes hydrolysis by intracellular...
Keywords: | GSH ethyl ester, L-gamma-glutamyl-L-cysteinyl-glycine, 3-ethyl ester |
Application: | Cell permeable glutathione transferase co-substrate |
CAS | 92614-59-0 |
MW: | 335.4 D |
From 48.00€ *
Item number: Cay19288-1
(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells). It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM). (1S,3R)-RSL3 reduces tumor...
Keywords: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
Application: | GPX4 inhibitor |
CAS | 1219810-16-8 |
MW: | 440.9 D |
From 32.00€ *
Item number: Cay17754-1
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Keywords: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
Application: | Antitumor agent |
CAS | 571203-78-6 |
MW: | 547.1 D |
From 44.00€ *
Item number: Cay71742-100
Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Keywords: | 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, monopotassium salt |
Application: | PPARgamma agonist |
CAS | 316371-84-3 |
MW: | 395.5 D |
From 32.00€ *
Item number: Cay10010338-50
Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Cay-10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form,...
Keywords: | 2S-methyl-butanoic acid,... |
Application: | NF-kappaB activation inhibitor |
CAS | 75330-75-5 |
MW: | 404.5 D |
From 25.00€ *
Item number: Cay71740-10
Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Keywords: | BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
Application: | PPARgamma agonist |
CAS | 122320-73-4 |
MW: | 357.4 D |
From 35.00€ *
Item number: Cay14595-500
Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high...
Keywords: | Ba 33112, DFOM, DFX, NSC 644468,... |
CAS | 138-14-7 |
MW: | 656.8 D |
From 63.00€ *