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Glutathione Peroxidase Assay Kit
Glutathione Peroxidase Assay Kit

Item number: Cay703102-96

Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Keywords: GPX Assay Kit
Application: GTx activity detection
From 357.00€ *
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Rosiglitazone
Rosiglitazone

Item number: Cay71740-10

Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Keywords: BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Application: PPARgamma agonist
CAS 122320-73-4
MW: 357.4 D
From 35.00€ *
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Glutathione Reductase Assay Kit
Glutathione Reductase Assay Kit

Item number: Cay703202-96

Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Keywords: GR Assay Kit
Application: GR activity detection
282.00€ *
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L-Buthionine-(S,R)-Sulfoximine
L-Buthionine-(S,R)-Sulfoximine

Item number: Cay14484-250

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki 98%. Formulation: A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=S(CCCC)(CC[C@H](N)C(O)=O)=N. InChi Code:...
Keywords: BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Application: Oxidative stress inducer
CAS 83730-53-4
MW: 222.3 D
From 82.00€ *
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Erastin
Erastin

Item number: Cay17754-1

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Keywords: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Application: Antitumor agent
CAS 571203-78-6
MW: 547.1 D
From 44.00€ *
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(1S,3R)-RSL3
(1S,3R)-RSL3

Item number: Cay19288-1

(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells). It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM). (1S,3R)-RSL3 reduces tumor...
Keywords: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,...
Application: GPX4 inhibitor
CAS 1219810-16-8
MW: 440.9 D
From 32.00€ *
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Lovastatin
Lovastatin

Item number: Cay10010338-5

Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Cay-10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form,...
Keywords: 2S-methyl-butanoic acid,...
Application: NF-kappaB activation inhibitor
CAS 75330-75-5
MW: 404.5 D
From 25.00€ *
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Ferrostatin-1
Ferrostatin-1

Item number: Cay17729-5

Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester
Application: Ferroptosis inhibitor
CAS 347174-05-4
MW: 262.4 D
From 50.00€ *
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Lipid Hydroperoxide (LPO) Assay Kit
Lipid Hydroperoxide (LPO) Assay Kit

Item number: Cay705002-100

Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: LPO quantification
303.00€ *
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Rosiglitazone (potassium salt)
Rosiglitazone (potassium salt)

Item number: Cay71742-100

Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter...
Keywords: 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, monopotassium salt
Application: PPARgamma agonist
CAS 316371-84-3
MW: 395.5 D
From 32.00€ *
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Lipid Hydroperoxide (LPO) Assay Kit (96 well)
Lipid Hydroperoxide (LPO) Assay Kit (96 well)

Item number: Cay705003-96

Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: LPO quantification
744.00€ *
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Glutathione ethyl ester
Glutathione ethyl ester

Item number: Cay14953-100

Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell-permeable derivative of GSH that undergoes hydrolysis by intracellular...
Keywords: GSH ethyl ester, L-gamma-glutamyl-L-cysteinyl-glycine, 3-ethyl ester
Application: Cell permeable glutathione transferase co-substrate
CAS 92614-59-0
MW: 335.4 D
From 48.00€ *
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