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COVID-19 Research
Item number: Cay30354-5
Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524 (Cay-30469). Upon entry into cells, remdesivir is metabolized into the nucleotide triphosphate GS-441524. Remdesivir is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV)...
Keywords: | GS-5734, N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with... |
Application: | GS-441524 prodrug, SARS type antiviral |
CAS | 1809249-37-3 |
MW: | 602.6 D |
From 110.00€ *
COVID-19 Research
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Item number: 200-401-A50
Protein function: Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. [The UniProt Consortium]
Keywords: | Anti-N, Anti-NC, Anti-9a, Anti-Protein N, Anti-Nucleoprotein, Anti-Nucleocapsid protein |
Application: | ELISA, WB, IF |
590.00€ *
COVID-19 Research
Item number: AG-48B-0001-KI01
To screen compounds that inhibit the binding of the viral protein SARS-CoV-2 Spike Protein (RBD) to its human receptor ACE2. Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many...
Keywords: | COVID-19 Inhibitor Screening Kit, 2019-nCoV Inhibitor Screening Kit, 2019-nCoV Spike Protein S1 (RBD)/ACE2 Inhibitor... |
Application: | Compound Screening |
Reactivity: | Human |
715.00€ *
COVID-19 Research
Item number: BPS-11003-1
Human Angiotensin converting enzyme 2 (ACE2) also known ACEH, GenBank Accession No. NP_068576.1, a.a. 18-740, with a C-terminal His-tag, expressed in a HEK293 expression system. MW=85 kDa.
Keywords: | ACE2, ACEH, angiotensin I converting enzyme 2, sars, sars protease, coronavirus, ncov |
Application: | Exopeptidase, Enzyme kinetics, Inhibitor screening, Protein-protein interaction studies |
Reactivity: | Human |
MW: | 85 kD |
From 380.00€ *
COVID-19 Research
Item number: E-PKSR030472.50
GenBank: QHD43415.1. Nsp3 is responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in...
Keywords: | Non-structural protein 3, nsp3, PL2-PROPapain-like proteinase, PL-PRO, SARS coronavirus main proteinase |
Reactivity: | Sars-cov-2 |
MW: | 34 kD |
From 240.00€ *
COVID-19 Research
Item number: SBB-DE0024-C050
The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or...
Keywords: | Papain-like Proteinase, SARS Coronavirus Main Proteinase, Non-structural Protein 3, PL2-PRO, Nsp3 |
Application: | Assays |
Reactivity: | Sars-cov |
MW: | 37 kD |
222.00€ *
COVID-19 Research
Item number: 51363.10
Purity: >99% (HPLC). Cell-permeable and irreversible inhibitor of calpain and other cystein proteases. Soluble in aqueous solutions. Stock solution: 1 mM, stable for months at -20 °C. Effective concentration: 1-10 µM.
Keywords: | E-64, Aloxistatin |
Application: | Inhibitor of cysteine proteases |
CAS | 66701-25-5 |
From 72.00€ *
COVID-19 Research
Item number: AG-CR1-3624-M025
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
Keywords: | INCB018424, INC 424 |
Application: | JAK1 inhibitor, JAK2 inhibitor |
CAS | 941678-49-5 |
MW: | 306,4 D |
From 72.00€ *
COVID-19 Research
Item number: Cay13533-1
Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways. E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64d inhibits calpain...
Keywords: | Aloxistatin, E-64c ethyl ester, EP 453, EST, Loxistatin, NSC 694281,... |
Application: | Protease inhibitor |
CAS | 88321-09-9 |
MW: | 342.4 D |
From 44.00€ *
COVID-19 Research
Item number: Cay15316-25
Auranofin is a gold-thiol complex with anti-inflammatory and immunosuppressive actions. It potently inhibits thioredoxin reductase (IC50 = 0.2 µM), preventing reduction of thioredoxin and altering oxidative signaling relevant to DNA synthesis, transcription, apoptosis, and disease. Auranofin blocks LPS-mediated...
Keywords: | NSC 321521, Ridauragold thiol, SKF 39162, [1-(thio-kappaS)-beta-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold |
Application: | Thioredoxin reductase inhibitor |
CAS | 34031-32-8 |
MW: | 678.5 D |
From 48.00€ *
COVID-19 Research
Item number: Cay17911-50
Hydroxychloroquine (HCQ) is a synthetic quinine derivative commonly used as an antimalarial drug. It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases. HCQ inhibits autophagy and induces autophagic cell death (IC50 = 30 µM), suggesting potential applications in...
Keywords: | HCQ, NSC 4375, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol, monosulfate |
Application: | Antimalarial, Lupus erythematosus suppressant |
CAS | 747-36-4 |
MW: | 434 D |
From 32.00€ *
COVID-19 Research
Item number: AG-20A-0032-C100
Recognizes human ACE2. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. ACE2 has direct effects on cardiac functions. It is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE2 converts angiotensin I to angiotensin 1-9. ACE2 was also identified as a functional...
Keywords: | SARS Receptor, Angiotensin-converting Enzyme 2, ACEH |
Application: | ELISA, FC, WB |
Reactivity: | Human |
From 187.00€ *