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Latrunculin B
Latrunculin B

Item number: AG-CN2-0031-M001

Isolated from Latrunculia magnifica. Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Less potent than Latrunculin A. May have fewer unwanted effects than latrunculin A and may be...
Keywords: LAT-B, NSC 339663
Application: Actin polymerization inhibitor
CAS 76343-94-7
MW: 395,5 D
99.00€ * From 79.20€ *
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MCC950 . Na
MCC950 . Na

Item number: AG-CR1-3615-M001

Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
Keywords: MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea
Application: NLRP3 inflammasome inhibitor
CAS 256373-96-3
MW: 426,5 D
39.00€ * From 31.20€ *
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Anti-NLRP3/NALP3, clone Cryo-2
Anti-NLRP3/NALP3, clone Cryo-2

Item number: AG-20B-0014-C100

Recognizes mouse and human NLRP3/NALP3. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the...
Keywords: NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein
Application: WB
Reactivity: Human , Mouse
308.00€ * 246.40€ *
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Anti-Polyglutamylation Modification, clone GT335
Anti-Polyglutamylation Modification, clone GT335

Item number: AG-20B-0020-C100

Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated alpha- and beta-tubulin. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on...
Keywords: Polyglutamylated Tubulin, Glutamylated Tubulin, Postranslational Protein Glutamylation
Application: ICC, IP, WB
Reactivity: All
418.00€ * 334.40€ *
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Anti-Caspase-1 (p20) (mouse), clone Casper-1
Anti-Caspase-1 (p20) (mouse), clone Casper-1

Item number: AG-20B-0042-C100

Recognizes endogenous full-length and activated (p20 fragement) mouse caspase-1. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response...
Keywords: Anti-CASP1, Anti-CASP-1, Anti-ICE, EC=3.4.22.36
Application: WB
Reactivity: Mouse
407.00€ * 325.60€ *
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Anti-Caspase-1 (p10) (mouse), clone Casper-2
Anti-Caspase-1 (p10) (mouse), clone Casper-2

Item number: AG-20B-0044-C100

Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4...
Keywords: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE
Application: WB
Reactivity: Mouse
407.00€ * 325.60€ *
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Anti-Caspase-1 (p20) (human), clone Bally-1
Anti-Caspase-1 (p20) (human), clone Bally-1

Item number: AG-20B-0048-C100

Recognizes endogenous full-length and activated (p20 fragment) human caspase-1. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic Caspase-1 is the best-described inflammatory caspase. It...
Keywords: Anti-CASP1, Anti-CASP-1, Anti-ICE
Application: WB
Reactivity: Human
407.00€ * 325.60€ *
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Anti-IL-33 (mouse)
Anti-IL-33 (mouse)

Item number: AG-25A-0047-C100

Recognizes mouse IL-33. Detects a band of about 18kDa by Western blot. Does not cross-react with human IL-33. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following...
Keywords: Interleukin-33, IL-1F11, NF-HEV
Application: ELISA, WB
Reactivity: Mouse
319.00€ * 255.20€ *
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Anti-Asc (AL177)
Anti-Asc (AL177)

Item number: AG-25B-0006-C100

Recognizes human and mouse Asc. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NALP2, CARD8...
Keywords: Pycard, Target of Methylation-induced Silencing 1, TMS1, Caspase Recruitment Domain-containing Protein 5,...
Application: ICC, IHC, IP, WB
Reactivity: Human , Mouse
440.00€ * 352.00€ *
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Anti-Polyglutamate chain [Poly-E]
Anti-Polyglutamate chain [Poly-E]

Item number: AG-25B-0030-C050

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and...
Keywords: Anti-Poly-E, pAb (IN105), Anti-Poly-Glu
Application: WB, ICC
Reactivity: Broad
385.00€ * 308.00€ *
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Anti-ADAM17 (human) (blocking), clone D1(A12)
Anti-ADAM17 (human) (blocking), clone D1(A12)

Item number: AG-27B-6000PF-C100

Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor...
Keywords: Anti-CSVP, Anti-ADAM17, Anti-CD156b, Anti-ADAM 17, EC=3.4.24.86, Anti-TNF-alpha convertase, Anti-Snake venom-like...
Application: FA (blocking)
Reactivity: Human
396.00€ * 316.80€ *
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Progranulin (human) (rec.) (untagged)
Progranulin (human) (rec.) (untagged)

Item number: AG-40A-0188Y-C050

Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa. Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as...
Keywords: GRN, Proepithelin, PEPI, PC Cell-derived Growth Factor
Application: Cell culture
Reactivity: Human
MW: 74 kD
187.00€ * From 149.60€ *
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