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Item number: Cay703102-96
Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Keywords: | GPX Assay Kit |
Application: | GTx activity detection |
From 444.00€
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Item number: Cay71740-10
Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...
Keywords: | BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
Application: | PPARgamma agonist |
CAS | 122320-73-4 |
MW: | 357.4 D |
From 43.00€
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Item number: Cay14484-250
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM)...
Keywords: | BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid |
Application: | Oxidative stress inducer |
CAS | 83730-53-4 |
MW: | 222.3 D |
From 109.00€
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Item number: Cay17754-5
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Keywords: | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone |
Application: | Antitumor agent |
CAS | 571203-78-6 |
MW: | 547.1 D |
From 60.00€
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Item number: Cay703202-96
Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Keywords: | GR Assay Kit |
Application: | GR activity detection |
352.00€
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Item number: Cay19288-5
(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...
Keywords: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
Application: | GPX4 inhibitor |
CAS | 1219810-16-8 |
MW: | 440.9 D |
From 43.00€
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Item number: Cay17729-5
Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: | Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester |
Application: | Ferroptosis inhibitor |
CAS | 347174-05-4 |
MW: | 262.4 D |
From 68.00€
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Item number: Cay27086-1
C11 BODIPY 581/591 is a lipid-soluble ratiometric fluorescent indicator of lipid oxidation. Upon oxidation, its excitation maximum shifts from 581 to 500 nm and the emission maximum shifts from 591 to 510 nm. C11 BODIPY 581/591 has been used in the quantitation of ferroptosis.Formal Name:...
Keywords: | (T-4)-difluoro[5-[[5-[(1E,3E)-4-phenyl-1,3-butadien-1-yl]-2H-pyrrol-2-ylidene-kappaN]methyl]-1H-pyrrole-2-undecanoato(2-)-... |
Application: | Lipid-soluble ratiometric fluorescent lipid oxidation indicator |
CAS | 217075-36-0 |
MW: | 504.4 D |
254.00€
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Item number: Cay81880-100
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO),...
Keywords: | BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride |
Application: | NOS cofactor |
CAS | 69056-38-8 |
MW: | 314.2 D |
From 50.00€
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Item number: Cay14595-500
Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high...
Keywords: | Ba 33112, DFO, DFOM, DFX, NSC 644468,... |
CAS | 138-14-7 |
MW: | 656.8 D |
From 98.00€
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Item number: Cay14953-100
Glutathione (GSH) ethyl ester is a cell-permeable derivative of GSH (Cay-10007461), a nucleophilic co-substrate to glutathione transferases. It increases mitochondrial GSH levels in C38 and IB3-1 epithelial lung cystic fibrosis cells when used at a concentration of 10 mM. GSH ethyl ester (10 mM) decreases reactive...
Keywords: | GSH ethyl ester, L-gamma-glutamyl-L-cysteinyl-glycine, 3-ethyl ester |
Application: | Cell permeable glutathione transferase co-substrate |
CAS | 92614-59-0 |
MW: | 335.4 D |
From 68.00€
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Item number: Cay705002-100
Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: | LPO quantification |
379.00€
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