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Glutathione Peroxidase Assay Kit
Glutathione Peroxidase Assay Kit

Item number: Cay703102-96

Glutathione peroxidase (GPX) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPX, a monomer, all of the GPX enzymes are tetramers of four identical subunits. Each...
Keywords: GPX Assay Kit
Application: GTx activity detection
From 444.00€ *
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Rosiglitazone
Rosiglitazone

Item number: Cay71740-10

Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...
Keywords: BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Application: PPARgamma agonist
CAS 122320-73-4
MW: 357.4 D
From 43.00€ *
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L-Buthionine-(S,R)-Sulfoximine
L-Buthionine-(S,R)-Sulfoximine

Item number: Cay14484-250

L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM)...
Keywords: BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Application: Oxidative stress inducer
CAS 83730-53-4
MW: 222.3 D
From 109.00€ *
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Erastin
Erastin

Item number: Cay17754-5

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cay-10011659), ferrostatin-1 (Cay-17729), U-0126 (Cay-70970), cycloheximide...
Keywords: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Application: Antitumor agent
CAS 571203-78-6
MW: 547.1 D
From 60.00€ *
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Glutathione Reductase Assay Kit
Glutathione Reductase Assay Kit

Item number: Cay703202-96

Glutathione reductase (GR, EC 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG) to glutathione (GSH). This enzyme is essential for the GSH redox cycle which maintains adequate levels of reduced cellular GSH. A high GSH/GSSG ratio is essential for protection...
Keywords: GR Assay Kit
Application: GR activity detection
352.00€ *
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(1S,3R)-RSL3
(1S,3R)-RSL3

Item number: Cay19288-5

(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...
Keywords: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,...
Application: GPX4 inhibitor
CAS 1219810-16-8
MW: 440.9 D
From 43.00€ *
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Ferrostatin-1
Ferrostatin-1

Item number: Cay17729-5

Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester
Application: Ferroptosis inhibitor
CAS 347174-05-4
MW: 262.4 D
From 68.00€ *
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C11 BODIPY 581/591
C11 BODIPY 581/591

Item number: Cay27086-1

C11 BODIPY 581/591 is a lipid-soluble ratiometric fluorescent indicator of lipid oxidation. Upon oxidation, its excitation maximum shifts from 581 to 500 nm and the emission maximum shifts from 591 to 510 nm. C11 BODIPY 581/591 has been used in the quantitation of ferroptosis.Formal Name:...
Keywords: (T-4)-difluoro[5-[[5-[(1E,3E)-4-phenyl-1,3-butadien-1-yl]-2H-pyrrol-2-ylidene-kappaN]methyl]-1H-pyrrole-2-undecanoato(2-)-...
Application: Lipid-soluble ratiometric fluorescent lipid oxidation indicator
CAS 217075-36-0
MW: 504.4 D
254.00€ *
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(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)

Item number: Cay81880-100

(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO),...
Keywords: BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride
Application: NOS cofactor
CAS 69056-38-8
MW: 314.2 D
From 50.00€ *
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Deferoxamine (mesylate)
Deferoxamine (mesylate)

Item number: Cay14595-500

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high...
Keywords: Ba 33112, DFO, DFOM, DFX, NSC 644468,...
CAS 138-14-7
MW: 656.8 D
From 98.00€ *
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Glutathione ethyl ester
Glutathione ethyl ester

Item number: Cay14953-100

Glutathione (GSH) ethyl ester is a cell-permeable derivative of GSH (Cay-10007461), a nucleophilic co-substrate to glutathione transferases. It increases mitochondrial GSH levels in C38 and IB3-1 epithelial lung cystic fibrosis cells when used at a concentration of 10 mM. GSH ethyl ester (10 mM) decreases reactive...
Keywords: GSH ethyl ester, L-gamma-glutamyl-L-cysteinyl-glycine, 3-ethyl ester
Application: Cell permeable glutathione transferase co-substrate
CAS 92614-59-0
MW: 335.4 D
From 68.00€ *
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Lipid Hydroperoxide (LPO) Assay Kit
Lipid Hydroperoxide (LPO) Assay Kit

Item number: Cay705002-100

Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive and unstable hydroperoxides of both saturated and unsaturated lipids. Our Lipid Hydroperoxide Assay Kit measures the hydroperoxides...
Application: LPO quantification
379.00€ *
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