7 products were found matching "Oligomycins"!
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Oligomycin A
Item number: Cay11342-5
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis...
| Keywords: | MCH 32,... |
| Application: | Apoptosis inducer |
| CAS | 579-13-5 |
| MW: | 791.1 D |
From 76.00€
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Oligomycin Complex
Item number: Cay11341-5
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins...
| Application: | ATP synthase inhibitor, Apoptosis inducer |
| CAS | 1404-19-9 |
| MW: | 789,3 D |
From 43.00€
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Oligomycin B
Item number: Cay11343-1
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin B is a nonselective inhibitor of the mitochondrial F1FO ATP synthase. Oligomycin B (1-10 µM) can reduce the rate...
| Keywords: | (1S,2'R,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,28R,29S)-22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydrox... |
| Application: | Apoptosis inducer |
| CAS | 11050-94-5 |
| MW: | 805.1 D |
From 54.00€
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Oligomycin C
Item number: Cay19162-1
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex (Cay-11341) that acts as an inhibitor of the mitochondrial...
| Keywords: | 12-deoxy Oligomycin A,... |
| Application: | Mitochondrial F1F0-ATP synthase inhibitor |
| CAS | 11052-72-5 |
| MW: | 775.1 D |
From 488.00€
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Oligomycin D
Item number: Cay20184-2.5
Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM...
| Keywords: | 26-Demethyloligomycin A, RR 32705, Rutamycin,... |
| Application: | Antibiotic, Mitochondrial F1FO-ATPase inhibitor, Oxidat. phosphorylation/electron transport uncoupler |
| CAS | 1404-59-7 |
| MW: | 777 D |
From 448.00€
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Oligomycin E
Item number: Cay20185-5
Oligomycin E is a minor metabolite of the oligomycin complex (Cay-11341) produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14...
| Keywords: | 26-hydroxy-28-oxo-Oligomycin A,... |
| Application: | Antibacterial (gram-positive), antitumor |
| CAS | 110231-34-0 |
| MW: | 821.1 D |
From 406.00€
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21-hydroxy Oligomycin A
Item number: Cay20599-5
21-hydroxy Oligomycin A is an antibiotic that was first isolated from S. cyaneogriseus ssp. noncyanogenus (LL-F28249). It is reported to be cytotoxic to human colon cancer SW620 cells (IC50 = 14.4 µM), to inhibit the ABC transporter efflux pump P-glycoprotein, and to prevent K-Ras plasma membrane localization (IC50...
| Keywords: | (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15,23... |
| Application: | Antibiotic |
| CAS | 102042-09-1 |
| MW: | 807.1 D |
From 444.00€
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