Catalogs from AdipoGen Life Sciences

InVivoKines - Proteins with Enhanced Activity & Stability for In Vivo Research

InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines™ are Fc-based fusion proteins produced under animal-freee conditions using the Knobs-into-Holes (KIH) technology. Due to the production in HEK 293 or CHO cells, InVivoKines™ show a native conformation. They display a high bioactivity tested by ELISA/cell-based assays, a verified purity and homogeneity, low endotoxin levels and Batch-to-Batch consistency. Released March 2024.

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Rare Antibiotics & Unique Natural Products

AdipoGen Life Sciences offers a broad panel of >500 natural products, from bacterial, fungal, marine and plant sources. This panel includes known active and well-characterized natural products in combination with unusual and difficult to isolate compounds, which are unique to AdipoGen Life Sciences. All compounds are structurally determined, purified and analytically validated. Included in this panel are key standard research antibiotics, rare metabolites/antibiotics with new chemical structures (often only described once in literature and afterward lost to research), or old already forgotten substances for lead drug research, seeking new “antibiotics” with a new mode of actions and new molecular targets. Updated February 2024.

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Obesity & Diabetes Research - Focus: Crucial Investment in the Future of Health - 5th Edition

In this brochure from AdipoGen Life Sciences, you will find products for obesity and diabetes research. Discover adipokines, obesity-related ELISA kits, antibodies and proteins, potent ANG-2 blocking antibodies as well as small molecule modulators for immunometabolism research. Learn more about the roles of interleukin-36 and -33 in obesity and adipose tissue homeostasis, respectively, and choose from a selection of suitable products for these biomolecules. You can also explore AdipoGen's collection of batokines and WAT browning and thermogenesis regulators or take advantage of their myokines portfolio (e.g. IL-6 and irisin). Updated November 2023.

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Inflammasome Research - From Innate to Adaptive Immunity - 3rd Edition

Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the maturation of the cytokines IL-1β and IL-18, and the processing of gasdermin D to mediate cytokine release and pyroptosis from cells of the innate immune system. Our partner AdipoGen Life Sciences is the expert for inflammasome research. Explore inflammasome tools like standard antibodies (e.g. for NLRP3) or for specific Caspase-1 detection. Make use of inflammasome “Priming” activators, microtubule antibodies and small molecule cytoskeletal modulators or find key NLRP3 inflammasome activators and inhibitors. Also, make sure to have a look at the NLRP3 wall chart to get an overview about NLRP3 inflammasome activation, signaling and regulation. Updated July 2023.

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AdipoGen Insights: Proteins with Enhanced Activity & Stability

Recombinant proteins are used throughout the life science academia and industry in a plethora of applications. Their use ranges from cell culture to bioprocessing and advanced cell and gene therapy. AdipoGen Life Sciences specializes in the development of high purity and low endotoxin recombinant proteins that show enhanced biological activity and long half-life. They are produced using different expression systems, including the mammalian cell lines CHO and HEK 293. Using proprietary in-house technologies together with established and published technologies, AdipoGen engineers, develops and produces an innovative panel of recombinant proteins for different research fields including cell therapy research. Relesed April 2023.

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ELISA Kits - 4th Edition

Explore the extensive collection of ELISA kits developed and manufactured by our partner AdipoGen Life Sciences. Choose from many different kits focusing on biomarkers from emerging research fields such as metabolic syndrome, inflammatory diseases or cancer and autoimmune diseases. Or take advantage of AdipoGen's validated SARS-CoV-2 research assays including neutralizing antibodies detection kits, inhibitor screening kits or an ACE2 ELISA kit. Updated January 2023.

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AdipoGen Insights: Progranulin - Marker of Neuroinflammation

Progranulin (PGRN) is a highly conserved secreted cysteine-rich protein that is expressed in multiple cell types, both in the CNS and in peripheral tissues. It is composed of seven ~6 kDa granulin proteins and regulates multifunctional biological activities, including major roles in cancer, inflammation, metabolic disease and neurodegeneration. PGRN is an abundant, non-conventional, stress-induced, extracellular matrix-bound secreted growth factor-like molecule and chaperone. The protein binds to several functionally different receptor families in a cell/tissue-specific and condition/disease-dependent manner. Mutations that reduce PGRN levels increase the risk for developing Alzheimer’s disease, Parkinson’s disease and other neurological diseases. Relesed January 2023.

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Neuroscience Research - Focus: Emerging Fields in Neuroinflammation & Neurological Diseases - 4th Edition

AdipoGen Life Sciences offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes biologically active Netrin-1 for axon outgrowth studies, the best inflammasomes research reagents to study the activation of neuroinflammation, biologically active Notch ligands, unique progranulin ELISA Kits and proteins, a broad range of adiponectin reagents, many Neurochemicals (including Gangliosides) and a unique polyglutamylation antibody. Updated November 2022.

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Key Inflammasome Research Tools

AdipoGen Life Sciences is the expert when it comes to inflammasome research. In this flyer, you will find some of their key inflammasome research tools:

 Relesed October 2022.

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TNF Superfamily - Key Cytokines in B & T Cell Immuno-Regulation

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 20 ligands and 30 receptors that play important roles in the modulation of cellular functions. TNFSF/TNFRSF members regulate cellular differentiation, survival and programmed death, but their most critical functions pertain to the immune system. Both innate and adaptive immune cells are controlled by TNFSF/TNFRSF members in a manner that is crucial for the coordination of various mechanisms driving either co-stimulation or co-inhibition of the immune response. Dysregulation of these same signaling pathways has been implicated in inflammatory and autoimmune diseases, highlighting the importance of their tight regulation. Relesed June 2022.

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AdipoGen Insights: Ubiquitin-Proteasome System

The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are the two major degradation systems for both native and misfolded proteins in eukaryotic cells. Several components of the UPS have been validated as potential anticancer targets. Download this brochure to find a selection of standard and non-standard proteasome inhibitors and modulators develped by AdipoGen. You will also get an overview about AdipoGen's fluorescent substrates for UPS activity measurement and proteasome complex modulators. Released November 2021.

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AdipoGen Insights: Autoimmune Disease Biomarkers APRIL & BAFF

The B cell-stimulating molecules, BAFF and APRIL, are critical factors in the maintenance of the B cell pool and humoral immunity. They are implicated in several human autoimmune diseases with autoreactive B cell involvement. Explore the portfolio of our partner AdipoGen Life Sciences focusing on BAFF and APRIL such as best-in-class ELISA kits or highly active proteins. Or choose from a broad selection of validated antibodies (including blocking antibodies). Other reagents for BAFF and APRIL research are monoclonal antibodies targeting Lymphotoxin-β receptor or recombinant IL-35. Updated October 2021.

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AdipoGen Insights: COVID-19 Research

Coronaviruses (CoVs) are enveloped non-segmented positive-sense RNA viruses infecting the respiratory, gastrointestinal, hepatic and central nervous system of human and many wild animals. Use this brochure to expand your knowledge about CoVs and ACE2, the key receptor for host cell entry of the pandemic-causing SARS CoVs, and learn more about biological therapeutic strategies against SARS-CoV-2 and COVID-19. Discover AdipoGen's tools such as assays, recombinant proteins and antibodies validated for ACE2 and COVID-19 research. In addition, you can choose from a wide collection of antiviral compounds for potential small molecule therapeutics against COVID-19. Released October 2020.

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Notch Signaling Pathway - Important for Cancer & T Cell Research

The highly conserved Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes throughout adulthood. Signaling via Notch occurs between receptors and its ligands, both at the surface of neighbouring cells. In mammals, expression of four Notch receptors (Notch1–4) and five canonical ligands [Delta-like ligand (DLL1, 3, 4) and Jagged (Jagged-1, -2) coordinate activation of this signaling pathway. Interested in Notch Signaling? Then check out AdipoGen's detailed Notch Signaling wallchart. Released May 2020.

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AdipoGen Insights: New Function of the Key Cytokine Interleukin-33

IL-33, a member of the IL-1 cytokine family, is constitutively expressed in fibroblasts, endothelial and epithelial cells exposed to the environment. IL-33 is a nuclearassociated cytokine that is normally released by damaged or necrotic cells acting as an “alarmin”, an immediate indicator of tissue stress. IL-33 is abundantly expressed in specific regions of brain and spinal cord, mediates the interaction between immune, endothelial and CNS (central nervous system) resident cells and plays a key role in the development and homeostasis of the CNS. IL-33 is involved in the neuroinflammation of many neurological diseases such as Alzheimer’s disease (AD) and multiple sclerosis (MS). Released February 2020.

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AdipoGen Insights: The Tubulin Code - Post-translational Modifications of Tubulins

The internal organization, shape, motility and life cycle of eukaryotic cells are all controlled by a complex network of polymeric filaments called the cytoskeleton, which includes actin filaments, intermediate filaments and microtubules (MTs). MTs are the largest cytoskeletal components involved in intracellular transport (cell signaling), cell migration/trafficking, cell division and proliferation. All MTs are assembled from heterodimers of α-tubulin and β-tubulin. Both tubulins and microtubules are major substrates for posttranslational modifications, which are crucial for fine-tuning of interactions between microtubules and different MT-interacting proteins. Released January 2020.

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Advanced Immune Regulation Reagents - 3rd Edition

AdipoGen Life Sciences offers a comprehensive panel of new and innovative products in the immune-regulation research field. This flyer gives an overview on unqiue and the newest antibodies, proteins, ELISA kits and small molecules developed by AdipoGen Life Sciences. Explore potent Th2 immune response blocking reagents, the widest panel of proteasome inhibitors, plasma cell survival and proliferation blocking antibodies, cytokines with increased activity, PTM-specific tubulin antibodies and antibodies for inflammasome research. Updated September 2019.

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Innate Immunity - Focus: Toll-like Receptors (TLR) Agonists - 2nd Edition

The innate immune system plays an essential role in the host’s first line of defense against microbial invasion and involves the recognition of pathogen-associated molecular patterns (PAMPs) or endogenous danger signals through the sensing of danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are a family of evolutionally conserved PRRs expressed by a variety of cell types, particularly those of the innate immune system. In this brochure, you can find AdipoGen's portfolio of TLR receptors agonists for TLR1/TLR2, TLR3/MDA5, TLR4/CD14, TLR5, TLR6/TLR2, TLR7/8, TLR9 and TLR11/12. Or explore RIG-I-like receptors and cytosolic DNA sensor agonists. If you prefer inhibition over activation, check out AdipoGen's TLR4 and TLR9 antagonists. On top, there is a PRR Signaling Pathways wall chart. Updated September 2019.

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AdipoGen Insights: Erythroferrone (human) ELISA Kit

Discover AdipoGen's Erythroferrone (human) ELISA Kit, the only specific and sensitive Erythroferrone assay on the Market! Erythroferrone (also called Myonectin, CTRP15, Fam132B or ERFE) is a hormone produced by erythroblasts in the bone marrow in response to erythropoietin controlling iron storage release or is a myokine abundantly expressed in skeletal muscle tissue, upregulated by voluntary exercise. Erythroferrone/Myonectin is a potential clinical biomarker for assessing erythropoiesis in patients with blood disorders, to study iron homeostasis for cardiovascular/heart protection, and potentially for metabolic disorders. Released May 2019.

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Immune Checkpoint Reagents - Focus: T Cells

Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving on the system's natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers.  AdipoGen Life Sciences offers a broad panel immune checkpoint reagents, including recombinant proteins, antibodies and ELISA Kits. Released March 2019.

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AdipoGen Insights: Gasdermin D Signaling & Inflammasome Research

Pyroptosis is an inflammatory programmed cell death that is initiated in response to pathogen- or host-derived perturbations of the cytosol. In human and mice, pyroptosis is induced by inflammatory caspases, such as caspase-1 and -11 that are activated by inflammasomes. Gasdermin D (GSDMD) is a central mediator of pyroptotic cell death. It contains a functional N-terminal domain and an inhibitory C-terminal domain. Upon caspase-1/11 cleavage of the linker located between the two domains of GSDMD, the cleaved N-terminal fragment of GSDMD oligomerizes and forms pores on the host cell membrane, leading to cell death called pyroptosis. AdipoGen Life Sciences is the leading manufacturer and supplier of inflammasome signaling research reagents. The validated high quality inflammasome research tools are used and published daily by the experts in the inflammasome research field. Released February 2019.

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Immunometabolism Research - Focus: Cell Metabolism & NAD+ Metabolism

Immunometabolism is a research field that provides new insights into the dynamic cross-talk between the immune system (immunity) and metabolic processes of an organism (metabolism). It tries to understand how metabolism controls the function of immune cells. AdipoGen Life Sciences offer a broad range of cell metabolism and NAD+ metabolism reagents. Choose from the collection of small molecule modulators of glycolysis, TCA Cycle, fatty acid oxidation and synthesis pathways and amino acid pathways. Discover inhibitors of IDO1 and Nampt or take advantage of biologically active enzymes including human arginase I, human IDO1 and mouse Nampt. Released July 2018.

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Functional Antibodies - Focus: Recombinant Antibodies - 3rd Edition

Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™)) are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Adipogen Life Sciences offers functional grade antibodies free of preservatives and tested for low endotoxin content and useful for activation, neutralizing or blocking studies, both in vitro or in vivo. Adipogen Life Sciences also offers recombinant monoclonal antibodies (RecMAbs™) generated by antibody phage display. An important attribute of the RecMAbs™ phage display approach is the ability to design selection strategies to generate antibodies with customized functions (FuncAbs™). Released February 2018.

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Interleukin-36γ - An Important Biomarker for Psoriasis

The proinflammatory cytokine IL-36γ is highly expressed in skin epithelial cells and in several myeloid-derived cell types. IL-36γ is a pivotal mediator of epithelial inflammation and is strongly associated with the inflammatory skin disease psoriasis. It also promotes wound healing after skin injury by regulating keratinocyte proliferation and assumes a role in the lung innate mucosal immunity during bacterial pneumonia by driving protective type-1 responses and classical macrophage activation, suggesting a potential key role in host defense. Discover IL-36γ ELISA kits, detection sets and antibodies as well as biologically active IL-36 proteins in this flyer. Released November 2017.

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