Comprehensive Tool Set for Kinase Research

c-Kit c-Met EGFR ErbB2 FGFR IGF-1R CSF1R FLT3 ALK DDR1 EphB3 Src MEKK2/3 MEK5 ERK5 JNK p38 RSK MNK Ras Raf MEK1/2 ERK1/2 IKK PKB/AKT mTOR S6K AMPK PDK1 PKC PI3K GSK3 JAK STAT FAK DNA-PK ATM C-Abl Chk1/2 Wee1 Aurora Plk Cdc25 CDK

Kinases are arguably one of the most important drug targets due to the roles their mutations, overexpression, and dysregulation play in all major pathologies, including immunological, inflammatory, degenerative, metabolic, cardiovascular, and infectious diseases. This is because kinases drive nearly every signal transduction process in the body.

Kinases catalyze the transfer of phosphate groups. Based upon the nature of the phosphorylated groups, these enzymes are classified as serine/threonine kinases, tyrosine kinases (including both receptor and non-receptor proteins), and tyrosine kinase-like enzymes. A small group of enzymes including MEK1/2, which catalyze the phosphorylation of both threonine and tyrosine residues within the activation segment of target proteins, are classified as dual specificity kinases.

More than 200 different orally effective protein kinase inhibitors are in clinical trials worldwide. A regularly updated listing of these trials can be found here. Notably, these compounds are directed against a small fraction (~40 different protein kinases) of the more than 500 members of the human protein kinase super family. The most common drug targets include ALK, B-RAF, Bcr-Abl, epidermal growth factor receptor (EGFR), and vascular endothelial growth factor receptor (VEGFR). Available antibodies, inhibitors, and screening libraries are enabling the drug discovery field to validate novel kinase targets, overcome drug resistance, obtain target selectivity (to reduce off-target effects), and develop efficient compound screening and profiling technologies.

Explore 1,155+ Kinase Inhibitors From Cayman Chemical

Click on any of the circles in the pathway image below to find inhibitors targeting specific kinases

Kinase-Signaling-Pathways

Signal transduction pathways for major kinases. Turquoise circles represent protein kinases, octagons represent related proteins, and pentagons represent second-messengers. Adapted from the Harvard Medical School LINCS CenterDownload this kinase pathway chart from Cayman.

 

Select Kinase Antibodies From Rockland Immunochemicals

Rockland Immunochemicals has a long-established history of providing critical antibodies for kinase research:

Antibody Reactivity Application
Anti-AKT Human (Expected: Mouse, Rat, Chicken) WB, IHC, IF, IP, ELISA
Anti-AKT, clone 18F10.E5 Human, Mouse (Expected: Rat, Chimpanzee) ELISA, WB, IHC
Anti-phospho-AKT (Ser473), clone 17F6.B11 Human, Mouse (Expected: Rat, Chimpanzee) ELISA, WB, IHC
Anti-phospho-AKT (Thr308), clone 18F3.H11 Human, Mouse (Expected: Wide) ELISA, WB, IHC
Anti-phospho-AKT (Thr308), DyLight(TM) 488 conjugated, clone 18F3.H11 Human, Mouse (Expected: Wide) IF, FLISA, FWB
Anti-phospho-AKT (Thr308) Human WB, ELISA
Anti-ATM Protein Kinase Human WB, IF, ELISA
Anti-phospho-ATM Protein Kinase (Ser1981), clone 10H11.E12 Human, Mouse, Rat ELISA, WB, IP, IF
Anti-phospho-ATM Protein Kinase (Ser1981), clone 7C10D8 Human, Mouse ELISA, WB, IHC, FC
Anti-phospho-ATM Protein Kinase (Ser1981) Human ELISA, WB
Anti-phospho-ATM Protein Kinase (Ser1981), Peroxidase conjugated, clone 10H11.E12 Human, Mouse ELISA, WB
Anti-phospho-ATM Protein Kinase (Ser1981), Biotin conjugated, clone 10H11.E12 Human, Mouse ELISA, WB, IP, IF
Anti-MEK1 C-Term, clone 13B6.G12 Human, Mouse, Rat ELISA, WB
Anti-phospho-MEK1 (Ser222)/phospho-MEK2 Ser226), clone 17C9.E1.H2.D7.H7.D5 Human, Mouse, Rat ELISA, WB
Anti-phospho-MEK1/2 (Ser218/Ser222) Human, Mouse, Rat WB
Anti-MEK2 N-Term Human, Mouse, Rat ELISA, IHC, WB
Anti-MEK2 N-Term, clone 19G10.F1.E2  Human, Mouse, Rat ELISA, WB
Anti-MEK2 C-Term, clone 12A6.G1.G11 Human, Mouse, Rat ELISA, WB

 

Simplify Screening and Hit-Seeking

Comprehensive Kinase Screening Library

Comprehensive-Kinase-Screening-Library

  • Consists of 11 plates with more than 850 selective and non-selective kinase inhibitors
  • Includes inhibitors of lipid, receptor and non-receptor tyrosine, serine/threonine, and dual specificity kinases
  • Targets include ROCK, ALK, GSK3, PKC, PDGFR, VEGFR, Src, MAPK, CDK, and PI3K families, among many others