Inflammasomes are multi-protein complexes whose activity has been implicated in physiological and pathological inflammation. The hallmarks of inflammasome activation are the maturation of the cytokines IL-1β and IL-18, and the processing of gasdermin D to mediate cytokine release and pyroptosis from cells of the innate immune system.
Progranulin is a stress-induced protein with multifunctional biological activities, including major roles in cancer, inflammation, metabolic diseases and neurodegeneration.
Pyroptosis is an inflammatory programmed cell death, which is induced by inflammatory caspases. During this process, Gasdermin D (GSDMD) is a central mediator of pyroptotic cell death.