Lipid nanoparticles (LNPs) are primed to revolutionize modern medicine. But the field is still in its infancy, and there are a number of challenges yet to overcome to unlock the full potential of LNPs.
Whether you are looking for a new angle in your research or are just curious, discover the top 10 most popular ELISAs by our partner Cayman Chemical in this article. Steroid hormone ELISAs populate the majority of this list, followed closely by ELISAs for lipid metabolites and cyclic nucleotide second messengers.
In our May 2021 blog article, we featured the 10 most cited products from our portfolio of more than 700,000 products. After more than a year, we decided to republish this article. What has changed? Are there any new products in the top 10, is there perhaps even a new frontrunner? And what's behind the products? In this blog article, you will get answers to all these questions.
Genes, proteins and chemicals often have rather complicated, meaningless names. However, some names deviate from the standardized nomenclature. But what exactly is behind molecules with names like Yoda or Spock? What are they used for in research? And how did they get their unusual names? Here's a list of the top 10 biomol products with the funniest names - and what's behind them!
The best-known variant of "lipid-based drug delivery systems" is the so-called lipid nanoparticle. In the second part of our LBDDS blog series, we will first provide an overview of the developmental history of LNPs and the "endosomal escape" – a crucial point in the transport pathway of LNPs. We will then go into the potential medical applications of LNPs – all the way to SARS-CoV-2 vaccination!
Lipid-based drug delivery systems (LBDDS) have been studied and developed since the 1960s. In 2020, this technology received a lot of attention due to its application in SARS-CoV-2 vaccination. In this first part of our LBDDS two-parter, we will focus on the structure and composition of lipid-based drug delivery systems and the different types of LBDDS. In addition to their application in mRNA vaccines, there are other possible uses for LBDDS, some of which we would like to introduce here.
Due to their large therapeutic window and broad-spectrum antiviral, immunomodulatory, anti-inflammatory, and antioxidant activities, natural products derived from plants or microbes and natural product-inspired small molecules have attracted considerable attention as potential agents to combat SARS-CoV-2, the causative agent of COVID-19.
Bacteria need some metabolites to survive. By disrupting the synthesis of these essential metabolites certain antibiotics inhibit bacterial growth.
By impairing the ability of the bacterial cell to produce ATP or other energy equivalents certain antibiotics inhibit bacterial growth. How do theses antibiotics target the energy metabolism?
There are different types of antibiotics targeting the ribosome, mRNA, tRNA or factors associated with translation. But how do these antibiotics inhibit protein synthesis?
There are several types of antibiotics inhibiting RNA or DNA replication and thereby prevent bacterial growth. But how do these antibiotics work?
As one of the most highly exploited medication classes, antibiotics address a broad range of bacterial infections by either killing, lysing, or stalling the growth of microbes. But how do these compounds work?