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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay26344-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
YTH domain containing 2 (YTHDC2) is an ATP-dependent 3'-5' RNA helicase and a member of the... more
Product information "YTHDC2 (human, recombinant)"
YTH domain containing 2 (YTHDC2) is an ATP-dependent 3'-5' RNA helicase and a member of the DExD/H-box family of helicases. YTHDC2 contains ATP binding, ATP hydrolysis, and RNA binding motifs. The YTH domain binds to N6-methyladenosine-modified germline messenger RNA to regulate meiotic gene expression in mammalian germ cells, mediating the mitotic-to-meiotic transition in mouse germ cells. Ythdc2-/- male and female mice show disrupted meiotic prophase progression. Male Ythdc2-/- mice have degraded germ cells and lack mature spermatozoa, while female Ythdc2-/- mice lack developing ovarian follicles and have few germ cells. YTHDC2 also facilitates hepatitis C virus (HCV) genome replication by binding to the HCV replication cofactor cyclophilin B and the HCV RNA polymerase non-structural protein 5B (NS5B). YTHDC2 downregulation inhibits proliferation in Huh7 hepatocellular carcinoma cells and reduces metastasis a Y2KD-116 mouse xenograft model using HCT116 cells in which YTHDC2 is downregulated. The expression of YTHDC2 in isolated human tumor tissue is positively correlated with tumor stage and lymph node metastasis.Synonyms: CsA-Associated Helicase-Like Protein, hYTHDC2, Probable ATP-Dependent RNA Helicase YTHDC2, 3'-5' RNA Helicase YTHDC2, YTH Domain-Containing Protein 2. Purity: >85% estimated by SDS-PAGE. Source: Recombinant N-terminal GST-tagged YTHDC2 purified from E. coli. Amino Acids: 1288-1421. MW: 42.13 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol. UniProt Accession #: Q9H6S0.
Keywords: | hYTHDC2, hYTHDC2, 3'-5' RNA helicase YTHDC2, 3'-5' RNA helicase YTHDC2, YTH domain-containing protein 2, YTH domain-containing protein 2 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 26344 |
Properties
Application: | WB |
Conjugate: | No |
Purity: | >85% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K20099 | Matching products |
UniProt ID : | Q9H6S0 | Matching products |
Gene ID | GeneID 64848 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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