Uroporphyrinogen III Synthase, Recombinant, Human, aa1-265, His-tag UROS, UROIIIS, Hydroxymethylbila

Uroporphyrinogen III Synthase, Recombinant, Human, aa1-265, His-tag UROS, UROIIIS, Hydroxymethylbila
Item number Size Datasheet Manual SDS Delivery time Quantity Price
U2740-31C.500 500 µg - -

1 - 19 business days

867.00€
 
UROS, also known as Uroporphyrinogen III synthase, is an enzyme involved in the fourth step of... more
Product information "Uroporphyrinogen III Synthase, Recombinant, Human, aa1-265, His-tag UROS, UROIIIS, Hydroxymethylbila"
UROS, also known as Uroporphyrinogen III synthase, is an enzyme involved in the fourth step of porphyrin metabolism, involved in the conversion of hydroxymethyl bilane into uroporphyrinogen III. Defects in this protein can cause molecular lesions that lead to the autosomal recessive Gunther disease, also known as congenital erythropoietic porphyria (CEP). Source: Recombinant corresponding to aa1-265 from human UROS, fused to His-tag at N-terminus expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGI AMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQA, LATGIRKALQ PHGCC, Molecular Weight: ~30.7kD (285aa) confirmed by MALDI-TOF, Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=4.2.1.75, Uroporphyrinogen-III synthase, Uroporphyrinogen-III cosynthase, Hydroxymethylbilane hydrolyase [cyclizing]
Supplier: United States Biological
Supplier-Nr: U2740-31C

Properties

Conjugate: No
MW: 30,7 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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