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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH033367.10 | 10 µg | - |
7 - 16 business days* |
38.00€
|
|||
E-PKSH033367.50 | 50 µg | - |
7 - 16 business days* |
125.00€
|
Protein Construction: Recombinant Human Ubiquitin-conjugating enzyme E2 D1 is produced by our... more
Product information "Ubiquitin-conjugating enzyme E2 D1 Protein (recombinant human)"
Protein Construction: Recombinant Human Ubiquitin-conjugating enzyme E2 D1 is produced by our E.coli expression system and the target gene encoding Met1-Met147 is expressed with a GST tag at the N-terminus. Sequence: Met 1-Met 147. Fusion tag: N-GST Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 25&50 kDa. Protein function: Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). [The UniProt Consortium]
Keywords: | SFT, UbcH5, UBE2D1, UBC4/5 homolog, Stimulator of Fe transport, Ubiquitin-protein ligase D1, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 D1, E2 ubiquitin-conjugating enzyme D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Recombinant Human U |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH033367 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 42.9 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K06689 | Matching products |
UniProt ID : | P51668 | Matching products |
Gene ID | GeneID 7321 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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