Ubiquitin-conjugating enzyme E2 D1 Protein (recombinant human)

Ubiquitin-conjugating enzyme E2 D1 Protein (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH033367.10 10 µg -

7 - 16 business days*

38.00€
E-PKSH033367.50 50 µg -

7 - 16 business days*

125.00€
 
Protein Construction: Recombinant Human Ubiquitin-conjugating enzyme E2 D1 is produced by our... more
Product information "Ubiquitin-conjugating enzyme E2 D1 Protein (recombinant human)"
Protein Construction: Recombinant Human Ubiquitin-conjugating enzyme E2 D1 is produced by our E.coli expression system and the target gene encoding Met1-Met147 is expressed with a GST tag at the N-terminus. Sequence: Met 1-Met 147. Fusion tag: N-GST Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 25&50 kDa. Protein function: Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). [The UniProt Consortium]
Keywords: SFT, UbcH5, UBE2D1, UBC4/5 homolog, Stimulator of Fe transport, Ubiquitin-protein ligase D1, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 D1, E2 ubiquitin-conjugating enzyme D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Recombinant Human U
Supplier: Elabscience
Supplier-Nr: E-PKSH033367

Properties

Conjugate: No
Host: E.coli
Species reactivity: human
MW: 42.9 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: +4°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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