UbcH7 [UBE2L3] (human) (rec.) (untagged)

UbcH7 [UBE2L3] (human) (rec.) (untagged)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
SBB-CE0020-C100 100 µg - -

3 - 9 business days*

396.00€
 
UBE2L3 (UbcH7) is an E2 ubiquitin conjugating enzyme and accepts ubiquitin from an E1 activating... more
Product information "UbcH7 [UBE2L3] (human) (rec.) (untagged)"
UBE2L3 (UbcH7) is an E2 ubiquitin conjugating enzyme and accepts ubiquitin from an E1 activating enzyme via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2L3-Ub thioester. UBE2L3 transfers active ubiquitin molecules via a final transthiolation reaction to a cysteine residue of HECT class or RBR class E3 ligases. UBE2L3 plays a critical role in the activation of NF-kappab signaling by working in conjugation with the RBR E3 ligase, LUBAC (linear ubiquitin assembly complex), to ubiquitinate NEMO of the IkappaB complex, which than facilitates the downstream immune response.
Keywords: Ubiquitin-conjugating Enzyme E2 L3, E2-F1, L-UBC, UBCE7, UbcM4, UBE2L3, Ubiquitin-protein Ligase L3
Supplier: South Bay Bio
Supplier-Nr: CE0020

Properties

Application: Assays
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 18 kD
Purity: >95%
Format: Liquid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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