STING H232 variant, SUMO-tagged (human, recombinant)

STING H232 variant, SUMO-tagged (human, recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15139-50 50 µg -

6 - 10 business days*

642.00€
 
STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable... more
Product information "STING H232 variant, SUMO-tagged (human, recombinant)"
STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). The H232 variant of STING is found at a 13.7% frequency in the 1000 Genome Project. The SNP variant R232 (Cay-22816) is the most common variant in the human population, found at a frequency of 57.9%. Small ubiquitin-like modifier (SUMO) proteins modify proteins post-translationally, leading to a variety of functional effects. In unstimulated cells in vitro, sumoylation stabilizes STING, inhibits its degradation, and facilitates oligomerization, leading to increased recruitment and activation of IRF3. In the early phase of herpes simplex virus type 1 (HSV-1) infection in vitro, dimerized STING is sumoylated by Trim38 and then desumoylated by Senp2 and degraded during the late phase of infection.Synonyms: ERIS, MITA, MPYS, Stimulator of Interferon Genes, TMEM173. Purity: >95% estimated by SDS-PAGE. Source: Recombinant N-terminal histidine- and SUMOpro-tagged protein expressed in E. coli. MW: 34.5 kDa. Formulation: (Request formulation change), 20 mM Tris, pH 7.5, containing 150 mM sodium chloride and 10% glycerol. License: SUMOpro tag was used under non-exclusive license from LifeSensors, Inc..
Keywords: ERIS, MITA, MPYS, Stimulator of Interferon Genes, TMEM173
Supplier: Cayman Chemical
Supplier-Nr: 15139

Properties

Application: Binding assays
Conjugate: No
Host: E.coli
MW: 34,5 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H315, H319, H372
P Phrases: P260, P264, P270, P280, P302+352, P305+351+338, P314, P321, P332+313, P337+313, P362+364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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