Product information "Speckle-type POZ Protein (SPOP) Recombinant, Human, aa1-374, His-tag"
Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3. [The UniProt Consortium]
HIB homolog 1, Roadkill homolog 1, Speckle-type POZ protein