Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32082-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
|||
Cay32082-1 | 1 mg | - |
6 - 10 business days* |
2,852.00€
|
Signal regulatory protein alpha (SIRPalpha) is an inhibitory transmembrane receptor encoded by... more
Product information "SIRPalpha Extracellular Domain (human, recombinant)"
Signal regulatory protein alpha (SIRPalpha) is an inhibitory transmembrane receptor encoded by SIRPA in humans. It is composed of three extracellular immunoglobulin-like (Ig-like) domains, a single transmembrane region, and a cytoplasmic domain that contains four tyrosine residues with immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are essential to SIRPalpha interaction with the Src homology region 2 (SH2) domain-containing phosphatases SHP-1 and SHP-2. SIRPalpha is expressed on monocytes, macrophages, granulocytes, subsets of dendritic cells in lymphoid tissues, some bone marrow progenitor cells, and neurons. Binding of CD47 (Cay-32085), a receptor expressed on healthy cells but often overexpressed in cancer cells, to SIRPalpha induces phosphorylation of the SIRPalpha ITIMs, coupling to SHP-1 or SHP-2, and repression of immune cell activation and phagocytosis. Knockout of Sirpa increases dopaminergic neuronal loss in the substantia nigra pars compacta and enhances striatal microglia activation in a mouse model of MPTP-induced Parkinson's disease. Sirpa-/- mice exhibit increased age-related podocyte injury and proteinuria compared with wild-type mice. SIRPA expression is decreased in patients with focal segmental glomerular sclerosis and in mouse models of renal injury induced by puromycin aminonucleoside (Cay-15509), doxorubicin (Cay-15007), or streptozotocin (Cay-13104). Cayman's SIRPalpha Extracellular Domain (human, recombinant) protein can be used for ELISA. This protein consists of 351 amino acids, has a calculated molecular weight of 39 kDa, and a predicted N-terminus of Glu31 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of this protein is 45 to 50 kDa due to glycosylation.Synonyms: CD172A, CD172 Antigen-like Family Member A, MyD-1 Antigen, SHPS-1, SHP Substrate 1, Signal Regulatory Protein alpha. Purity: >98% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Active recombinant human C-terminal His-tagged SIRPalpha expressed in HEK293 cells. Amino Acids: 31-370. MW: 39 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P78324-2.
Keywords: | BIT, Bit, p84, Bit, p84, SIRPA, SHPS-1, CD172a, SHPS-1, CD172a, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, MyD-1 antigen, MyD-1 antigen, SHP substrate 1, SHP substrate 1, Inhibitory receptor SHPS-1, Macrophage fusi |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32082 |
Properties
Conjugate: | No |
Purity: | >98% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K06551 | Matching products |
UniProt ID : | P78324 | Matching products |
Gene ID | GeneID 140885 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed